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Review
. 2019 Feb;44(2):153-166.
doi: 10.1016/j.tibs.2018.10.011. Epub 2018 Nov 22.

Lactate: A Metabolic Driver in the Tumour Landscape

Luigi Ippolito  1 , Andrea Morandi  1 , Elisa Giannoni  1 , Paola Chiarugi  2
Affiliations
Review

Lactate: A Metabolic Driver in the Tumour Landscape

Luigi Ippolito et al. Trends Biochem Sci. 2019 Feb.

Abstract

The presence of lactate in human tumours has been long neglected, confined to the role of a waste product derived from glycolysis and as a biomarker of malignancy. More recently, lactate has been rediscovered as signalling molecule that plays important roles in the regulation of the metabolic pathways, the immune response, and cell-to-cell communication within the tumour microenvironment. This review examines recent discoveries about the functional role of lactate in shaping the behaviour and the phenotype of tumour and tumour-associated cells, and describes potential clinical approaches to target lactate transport and metabolism in tumours.

Keywords: mitochondria; tumour metabolism; tumour microenvironment; tumour–stroma interplay.

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