MDMA modulates 5-HT1-mediated contractile response of the human internal thoracic artery in vitro
- PMID: 30448555
- DOI: 10.1016/j.tiv.2018.11.006
MDMA modulates 5-HT1-mediated contractile response of the human internal thoracic artery in vitro
Abstract
3,4-Methylenedioxymethamphetamine (MDMA or "ecstasy") is a popular recreational drug of abuse. In addition to its characteristic psychotropic effects, important cardiovascular effects have been described such as increased blood pressure and heart rate. MDMA was previously shown to behave as a partial agonist on 5-hydroxytryptamine (5-HT) receptors in the human internal thoracic artery in vitro, involving the 5-HT2A subtype. Here, we studied the interaction of MDMA (400, 800 and 1600 μM) with the following 5-HT receptor agonists: 5-carboxamidotryptamine (5-CT, full agonist for the 5-HT1, 5-HT2, 5-HT5, 5-HT6 and 5-HT7 receptors) and sumatriptan (selective 5-HT1B/1D receptors agonist). The results showed the ability of MDMA to influence the concentration-dependent response of 5-CT (97.3% of maximal reduction for 1600 μM of MDMA) and sumatriptan (72.43% of maximal reduction for 1600 μM of MDMA). The lower concentration of MDMA (400 μM) produced a significant potentiation of the response to sumatriptan thus suggesting an interaction of MDMA with the activation of 5-HT receptors, namely of the 5-HT1 subtype, in the peripheral vasculature. Together our results further support the importance of the affinity of MDMA to 5-HT receptors in the vascular effects of this drug.
Keywords: 3,4-Methylenedioxymethamphetamine; 5-HT(1) receptors; Human internal thoracic artery; MDMA; Sumatriptan; Vascular effects.
Copyright © 2018. Published by Elsevier Ltd.
Similar articles
-
Contractile effects of 3,4-methylenedioxymethamphetamine on the human internal mammary artery.Toxicol In Vitro. 2016 Aug;34:187-193. doi: 10.1016/j.tiv.2016.04.002. Epub 2016 Apr 11. Toxicol In Vitro. 2016. PMID: 27079619
-
Pharmacological studies of the acute and chronic effects of (+)-3, 4-methylenedioxymethamphetamine on locomotor activity: role of 5-hydroxytryptamine(1A) and 5-hydroxytryptamine(1B/1D) receptors.J Pharmacol Exp Ther. 1999 Sep;290(3):965-73. J Pharmacol Exp Ther. 1999. PMID: 10454466
-
Hyperthermia Severely Affects the Vascular Effects of MDMA and Metabolites in the Human Internal Mammary Artery In Vitro.Cardiovasc Toxicol. 2017 Oct;17(4):405-416. doi: 10.1007/s12012-017-9398-y. Cardiovasc Toxicol. 2017. PMID: 28084566
-
3,4-Methylenedioxymethamphetamine (MDMA) as a unique model of serotonin receptor function and serotonin-dopamine interactions.J Pharmacol Exp Ther. 2001 Jun;297(3):846-52. J Pharmacol Exp Ther. 2001. PMID: 11356903 Review.
-
Ecstasy (3,4-methylenedioxymethamphetamine): Cardiovascular effects and mechanisms.Eur J Pharmacol. 2021 Jul 15;903:174156. doi: 10.1016/j.ejphar.2021.174156. Epub 2021 May 8. Eur J Pharmacol. 2021. PMID: 33971177 Review.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical