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Comment
. 2018 Nov 12;34(5):693-694.
doi: 10.1016/j.ccell.2018.10.011.

CHAF1B Overexpression: A Brake for the Differentiation of Leukemia Cells

Qing Li  1 , Xu Zhang  2 , Zhiguo Zhang  3
Affiliations
Comment

CHAF1B Overexpression: A Brake for the Differentiation of Leukemia Cells

Qing Li et al. Cancer Cell. .

Abstract

In this issue of Cancer Cell, Volk et al. report that overexpression of CHAF1B displaces myeloid transcription factors from chromatin, and deletion of CHAF1B promotes differentiation of leukemia cells and suppresses leukemogenesis in a murine model, revealing a causal role of and an unexpected mechanism for CHAF1B overexpression in tumorigenesis.

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Figures

Figure 1:
Figure 1:. A model for CHAF1B overexpression in leukemogenesis.
TF: transcription factors. CHAF1B, shown in the figure, is known to form with CHAF1A and RBAP48 a complex that assembles new H3-H4 tetramers into nucleosomes following DNA replication.
See this image and copyright information in PMC

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