Cutaneous immunohistochemical staining pattern of p53β isoforms
- PMID: 30305316
- DOI: 10.1136/jclinpath-2018-205098
Cutaneous immunohistochemical staining pattern of p53β isoforms
Abstract
p53 is considered the guardian of the genome and as such has numerous functions. The TP53 gene is the most commonly mutated gene in cancer, and yet the exact biological significance of such mutations remains unclear. There are at least 12 different isoforms of p53, and the complexity of the p53 pathway may be in part related to these isoforms. Prior research has often not teased out what isoforms of p53 are being studied, and there is evidence in the literature that p53 isoforms are expressed differently. In this paper, we document the staining pattern of p53β isoforms in the skin and correlate it with mutational status in a subgroup of squamous proliferations of the skin. p53β isoforms are present in the cytoplasm of the differentiated layer of the epidermis and hair follicles (granular layer, infundibular and isthmus-catagen). p53β isoforms are diffusely expressed within the cytoplasm of well-differentiated squamous tumours with tetramerisation (C-terminal) domain mutations in TP53 Our results lend support to p53β isoforms being a marker of differentiation in keratinocytes.
Keywords: P53; skin; staining.
© Author(s) (or their employer(s)) 2018. No commercial re-use. See rights and permissions. Published by BMJ.
Conflict of interest statement
Competing interests: None declared.
Similar articles
-
Modulation of p53β and p53γ expression by regulating the alternative splicing of TP53 gene modifies cellular response.Cell Death Differ. 2014 Sep;21(9):1377-87. doi: 10.1038/cdd.2014.73. Epub 2014 Jun 13. Cell Death Differ. 2014. PMID: 24926616 Free PMC article.
-
Cytoplasmic p53β Isoforms Are Associated with Worse Disease-Free Survival in Breast Cancer.Int J Mol Sci. 2022 Jun 15;23(12):6670. doi: 10.3390/ijms23126670. Int J Mol Sci. 2022. PMID: 35743117 Free PMC article.
-
Identification of nonsense-mediated mRNA decay pathway as a critical regulator of p53 isoform β.Sci Rep. 2017 Dec 13;7(1):17535. doi: 10.1038/s41598-017-17283-4. Sci Rep. 2017. PMID: 29235495 Free PMC article.
-
Dynamic life of a skin keratinocyte: an intimate tryst with the master regulator p63.Indian J Exp Biol. 2011 Oct;49(10):721-31. Indian J Exp Biol. 2011. PMID: 22013738 Review.
-
p53 Isoforms and Their Implications in Cancer.Cancers (Basel). 2018 Aug 25;10(9):288. doi: 10.3390/cancers10090288. Cancers (Basel). 2018. PMID: 30149602 Free PMC article. Review.
Cited by
-
The Emerging Landscape of p53 Isoforms in Physiology, Cancer and Degenerative Diseases.Int J Mol Sci. 2019 Dec 11;20(24):6257. doi: 10.3390/ijms20246257. Int J Mol Sci. 2019. PMID: 31835844 Free PMC article. Review.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Research Materials
Miscellaneous
