Dehydroepiandrosterone and Dehydroepiandrosterone-Sulfate and Emotional Processing
- PMID: 30029737
- DOI: 10.1016/bs.vh.2018.01.022
Dehydroepiandrosterone and Dehydroepiandrosterone-Sulfate and Emotional Processing
Abstract
Steroid hormones are important regulators of brain development, physiological function, and behavior. Among them, dehydroepiandrosterone (DHEA) and dehydroepiandrosterone-sulfate (DHEAS) also do modulate emotional processing and may have mood enhancement effects. This chapter reviews the studies that bear relation to DHEA and DHEAS [DHEA(S)] and brain emotional processing and behavior. A brief introduction to the mechanisms of action and variations of DHEA(S) levels throughout life has also been forward in this chapter. Higher DHEA(S) levels may reduce activity in brain regions involved in the generation of negative emotions and modulate activity in regions involved in regulatory processes. At the electrophysiological level, higher DHEA-to-cortisol and DHEAS-to-DHEA ratios were related to shorter P300 latencies and shorter P300 amplitudes during the processing of negative stimuli, suggesting less interference of negative stimuli with the task and less processing of the negative information, which in turn may suggest a protective mechanism against negative information overload. Present knowledge indicates that DHEA(S) may play a role in cortical development and plasticity, protecting against negative affect and depression, and at the same time enhancing attention and overall working memory, possibly at the cost of a reduction in emotional processing, emotional memory, and social understanding.
Keywords: Attention; Cortisol; Dehydroepiandrosterone; Dehydroepiandrosterone-sulfate; Depression; Emotion processing; Emotional memory; Event-related potentials; Neuroimaging.
© 2018 Elsevier Inc. All rights reserved.
Similar articles
-
Dehydroepiandrosterone (DHEA) and dehydroepiandrosterone-sulfate (DHEAS) and emotional processing - A behavioral and electrophysiological approach.Horm Behav. 2015 Jul;73:94-103. doi: 10.1016/j.yhbeh.2015.06.005. Epub 2015 Jun 27. Horm Behav. 2015. PMID: 26122298 Clinical Trial.
-
The relationship between dehydroepiandrosterone (DHEA), working memory and distraction--a behavioral and electrophysiological approach.PLoS One. 2014 Aug 8;9(8):e104869. doi: 10.1371/journal.pone.0104869. eCollection 2014. PLoS One. 2014. PMID: 25105970 Free PMC article.
-
Hormonal modulation of novelty processing in women: Enhanced under working memory load with high dehydroepiandrosterone-sulfate-to-dehydroepiandrosterone ratios.Neurosci Lett. 2016 Nov 10;634:98-103. doi: 10.1016/j.neulet.2016.10.002. Epub 2016 Oct 4. Neurosci Lett. 2016. PMID: 27717832
-
Neurobiological and neuropsychiatric effects of dehydroepiandrosterone (DHEA) and DHEA sulfate (DHEAS).Front Neuroendocrinol. 2009 Jan;30(1):65-91. doi: 10.1016/j.yfrne.2008.11.002. Epub 2008 Dec 3. Front Neuroendocrinol. 2009. PMID: 19063914 Free PMC article. Review.
-
[Dehydroepiandrosterone (DHEA)--youth hormone?].Wiad Lek. 2001;54(11-12):693-704. Wiad Lek. 2001. PMID: 11928558 Review. Polish.
Cited by
-
Gender Differences in Perceived Stress and Its Relationship to Telomere Length in Costa Rican Adults.Front Psychol. 2022 Feb 25;13:712660. doi: 10.3389/fpsyg.2022.712660. eCollection 2022. Front Psychol. 2022. PMID: 35282254 Free PMC article.
-
Inter-individual differences in pain anticipation and pain perception in migraine: Neural correlates of migraine frequency and cortisol-to-dehydroepiandrosterone sulfate (DHEA-S) ratio.PLoS One. 2021 Dec 20;16(12):e0261570. doi: 10.1371/journal.pone.0261570. eCollection 2021. PLoS One. 2021. PMID: 34929017 Free PMC article.
-
Chronic Depression Alters Mothers' DHEA and DEHA-to-Cortisol Ratio: Implications for Maternal Behavior and Child Outcomes.Front Psychiatry. 2020 Jul 22;11:728. doi: 10.3389/fpsyt.2020.00728. eCollection 2020. Front Psychiatry. 2020. PMID: 32793012 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Miscellaneous