Clinical Improvements in Very Dry Skin from a Natural Ingredient-Based Moisturizing Cream Compared With a Leading Colloidal Oatmeal Control
- PMID: 30005098
Clinical Improvements in Very Dry Skin from a Natural Ingredient-Based Moisturizing Cream Compared With a Leading Colloidal Oatmeal Control
Abstract
The objective of this 6-week clinical study was to demonstrate the effectiveness of a natural ingredient-based moisturizing cream versus a colloidal oatmeal moisturizing cream in improving the hydration, barrier function, appearance, and feel of dry leg skin. Thirty-two subjects completed the study. After a 5-day washout, subjects used the natural ingredient-based moisturizing cream and oatmeal-containing cream on randomly-assigned legs twice a day for a period of three weeks. For the following two weeks subjects did not use any moisturizer on their legs. Skin moisture measurements showed a statistically significant increase in hydration for both products at all time points during the treatment phase of the study. Both products reduced transepidermal water loss measurements during the treatment phase of the study, showing their abilities to improve stratum corneum barrier function. Clinical evaluations showed that both products significantly decreased visual dryness and tactile roughness during the treatment phase. Improvements in the assessed clinical parameters persisted even after treatment cessation. In conclusion, the natural ingredient-based moisturizing cream was highly effective in providing moisturization and improving the skin barrier of subjects with very dry leg skin. It also produced significant improvements in visual dryness and tactile roughness that persisted during regression. Overall, these results show that the natural ingredient-based moisturizing cream delivers comparable benefits to that of a colloidal oatmeal-containing benchmark product and is an option for health care providers and consumers who seek relief from dry skin and prefer a product with all-natural ingredients. J Drugs Dermatol. 2018;17(7):758-764.
Similar articles
-
Effects of Colloidal Oatmeal Topical Atopic Dermatitis Cream on Skin Microbiome and Skin Barrier Properties.J Drugs Dermatol. 2020 May 1;19(5):524-531. J Drugs Dermatol. 2020. PMID: 32484623 Clinical Trial.
-
The 24-hr, 28-day, and 7-day post-moisturizing efficacy of ceramides 1, 3, 6-II containing moisturizing cream compared with hydrophilic cream on skin dryness and barrier disruption in senile xerosis treatment.Dermatol Ther. 2019 Nov;32(6):e13090. doi: 10.1111/dth.13090. Epub 2019 Oct 9. Dermatol Ther. 2019. PMID: 31585489 Clinical Trial.
-
Colloidal Oatmeal <em>(Avena Sativa)</em> Improves Skin Barrier Through Multi-Therapy Activity.J Drugs Dermatol. 2016 Jun 1;15(6):684-90. J Drugs Dermatol. 2016. PMID: 27272074 Clinical Trial.
-
Treatments Improving Skin Barrier Function.Curr Probl Dermatol. 2016;49:112-22. doi: 10.1159/000441586. Epub 2016 Feb 4. Curr Probl Dermatol. 2016. PMID: 26844903 Review.
-
Role of topical emollients and moisturizers in the treatment of dry skin barrier disorders.Am J Clin Dermatol. 2003;4(11):771-88. doi: 10.2165/00128071-200304110-00005. Am J Clin Dermatol. 2003. PMID: 14572299 Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources