The association between serum progesterone level and preterm delivery
- PMID: 29885043
- DOI: 10.1002/ijgo.12564
The association between serum progesterone level and preterm delivery
Abstract
Objective: To investigate the association of serum progesterone level and preterm delivery.
Methods: The present prospective cohort study enrolled women with singleton pregnancies attending their first prenatal visit at the outpatient specialist clinics at KK Women's and Children's Hospital, Singapore, between September 1, 2010, and August 31, 2014. Progesterone levels were measured at four clinical visits (visit 1: 9-14 weeks; visit 2: 18-22 weeks; visit 3: 28-32 weeks; visit 4: >34 weeks) and were compared (after adjusting for potential confounders) between patients who had term and preterm deliveries, and among subgroups of spontaneous preterm and iatrogenic preterm deliveries.
Results: There were 708 patients included. Serum progesterone levels at visit 3 were higher in the preterm delivery group than in the term delivery group (P=0.036). The levels did not differ between the two groups at other visits (all P>0.05). In the subgroup analysis, progesterone levels were higher in the iatrogenic preterm delivery subgroup than the term subgroup at visits 1 and 3. A progesterone cut-off level of 304.5 nmol/L demonstrated 81.8% sensitivity, 40.1% specificity, and negative and positive predictive values of 97.5% and 7.2%, respectively, as a predictor of preterm delivery.
Conclusion: Higher serum progesterone levels at 28-32 weeks of pregnancy were observed in women who had preterm deliveries; it was weakly predictive of preterm delivery.
Keywords: Asian; Iatrogenic preterm birth; Pregnancy; Preterm birth; Serum progesterone; Spontaneous preterm birth; Three trimesters.
© 2018 International Federation of Gynecology and Obstetrics.
Similar articles
-
Association between serum progesterone concentration in early pregnancy and duration of pregnancy: a cohort study.J Matern Fetal Neonatal Med. 2020 Jun;33(12):2096-2102. doi: 10.1080/14767058.2018.1540580. Epub 2018 Nov 25. J Matern Fetal Neonatal Med. 2020. PMID: 30474453
-
Controlled ovarian hyperstimulation leads to high progesterone and estradiol levels during early pregnancy.Hum Reprod. 2014 Nov;29(11):2393-401. doi: 10.1093/humrep/deu223. Epub 2014 Sep 8. Hum Reprod. 2014. PMID: 25205752
-
Vaginal progesterone combined with cervical pessary: A chance for pregnancies at risk for preterm birth?Am J Obstet Gynecol. 2016 Jun;214(6):739.e1-739.e10. doi: 10.1016/j.ajog.2015.12.007. Epub 2015 Dec 12. Am J Obstet Gynecol. 2016. PMID: 26692180
-
[Prevention of spontaneous preterm birth (excluding preterm premature rupture of membranes): Guidelines for clinical practice - Text of the Guidelines (short text)].J Gynecol Obstet Biol Reprod (Paris). 2016 Dec;45(10):1446-1456. doi: 10.1016/j.jgyn.2016.09.011. Epub 2016 Nov 9. J Gynecol Obstet Biol Reprod (Paris). 2016. PMID: 27836377 Review. French.
-
Progesterone for preterm birth prevention.Obstet Gynecol Clin North Am. 2012 Mar;39(1):1-16, vii. doi: 10.1016/j.ogc.2011.12.004. Epub 2012 Jan 24. Obstet Gynecol Clin North Am. 2012. PMID: 22370103 Review.
Cited by
-
Preterm birth, a consequence of immune deviation mediated hyperinflammation.Heliyon. 2024 Mar 24;10(7):e28483. doi: 10.1016/j.heliyon.2024.e28483. eCollection 2024 Apr 15. Heliyon. 2024. PMID: 38689990 Free PMC article. Review.
-
Gestational Hormone Concentrations Are Associated With Timing of Delivery in a Fetal Sex-Dependent Manner.Front Endocrinol (Lausanne). 2021 Sep 15;12:742145. doi: 10.3389/fendo.2021.742145. eCollection 2021. Front Endocrinol (Lausanne). 2021. PMID: 34603214 Free PMC article.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical