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Randomized Controlled Trial
. 2019 Feb;49(3):491-500.
doi: 10.1017/S0033291718001113. Epub 2018 May 24.

Efficacy of digital CBT for insomnia to reduce depression across demographic groups: a randomized trial

Philip Cheng  1 , Annemarie I Luik  2 , Cynthia Fellman-Couture  1 , Edward Peterson  1 , Christine L M Joseph  1 , Gabriel Tallent  1 , Kieulinh Michelle Tran  1 , Brian K Ahmedani  1 , Timothy Roehrs  1 , Thomas Roth  1 , Christopher L Drake  1
Affiliations
Randomized Controlled Trial

Efficacy of digital CBT for insomnia to reduce depression across demographic groups: a randomized trial

Philip Cheng et al. Psychol Med. 2019 Feb.

Abstract

Background: Insomnia and depression are highly comorbid and mutually exacerbate clinical trajectories and outcomes. Cognitive behavioral therapy for insomnia (CBT-I) effectively reduces both insomnia and depression severity, and can be delivered digitally. This could substantially increase the accessibility to CBT-I, which could reduce the health disparities related to insomnia; however, the efficacy of digital CBT-I (dCBT-I) across a range of demographic groups has not yet been adequately examined. This randomized placebo-controlled trial examined the efficacy of dCBT-I in reducing both insomnia and depression across a wide range of demographic groups.

Methods: Of 1358 individuals with insomnia randomized, a final sample of 358 were retained in the dCBT-I condition and 300 in the online sleep education condition. Severity of insomnia and depression was examined as a dependent variable. Race, socioeconomic status (SES; household income and education), gender, and age were also tested as independent moderators of treatment effects.

Results: The dCBT-I condition yielded greater reductions in both insomnia and depression severity than sleep education, with significantly higher rates of remission following treatment. Demographic variables (i.e. income, race, sex, age, education) were not significant moderators of the treatment effects, suggesting that dCBT-I is comparably efficacious across a wide range of demographic groups. Furthermore, while differences in attrition were found based on SES, attrition did not differ between white and black participants.

Conclusions: Results provide evidence that the wide dissemination of dCBT-I may effectively target both insomnia and comorbid depression across a wide spectrum of the population.

Keywords: CBT-I; Clinical Trial Identifier: NCT02988375; Clinical Trial Registry: clinicaltrials.gov; Internet; depression; insomnia.

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Figures

Fig. 1.
Fig. 1.
Flow chart of study recruitment and enrollment.
Fig. 2.
Fig. 2.
Change in ISI scores between the dCBT-I and sleep education conditions. Error bars indicate standard error of the mean. Experimental conditions in Panel A have been jittered for visual clarity and do not represent timing of treatments.
Fig. 3.
Fig. 3.
Change in QIDS scores between the dCBT-I and sleep education conditions.
Fig. 4.
Fig. 4.
Change in non-sleep items on the QIDS by experimental condition.
Fig. 5.
Fig. 5.
Change in insomnia and depression in the dCBT-I condition by household income brackets.
See this image and copyright information in PMC

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