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Randomized Controlled Trial
. 2018 Mar 29;10(4):424.
doi: 10.3390/nu10040424.

The Effects of Isoflavone Supplementation Plus Combined Exercise on Lipid Levels, and Inflammatory and Oxidative Stress Markers in Postmenopausal Women

Jéssica S Giolo  1 , Juliene G Costa  2 , Jair P da Cunha-Junior  3 , Ana Cláudia A M Pajuaba  4 , Ernesto A Taketomi  5 , Adriele V de Souza  6 , Douglas C Caixeta  7 , Leonardo G Peixoto  8 , Erick P de Oliveira  9 , Sarah Everman  10 , Foued S Espindola  11 , Guilherme M Puga  12
Affiliations
Randomized Controlled Trial

The Effects of Isoflavone Supplementation Plus Combined Exercise on Lipid Levels, and Inflammatory and Oxidative Stress Markers in Postmenopausal Women

Jéssica S Giolo et al. Nutrients. .

Abstract

This study tested the effect of isoflavone supplementation in addition to combined exercise training on plasma lipid levels, inflammatory markers and oxidative stress in postmenopausal women. Thirty-two healthy and non-obese postmenopausal women without hormone therapy were randomly assigned to exercise + placebo (PLA; n = 15) or exercise + isoflavone supplementation (ISO; n = 17) groups. They performed 30 sessions of combined exercises (aerobic plus resistance) over ten weeks and consumed 100 mg of isoflavone supplementation or placebo. Blood samples were collected after an overnight fast to analyze the lipid profile, interleukin-6 (IL-6), interleukin-8 (IL-8), superoxide dismutase (SOD), total antioxidant capacity (FRAP), and thiobarbituric acid reactive substances (TBARS), before and after ten weeks of the intervention. There were no differences in the changes (pre vs. post) between groups for any of the inflammatory markers, oxidative stress markers or lipid profile variables. However, interleukin-8 was different between pre- and post-tests (p < 0.001) in both groups (&Delta; = 7.61 and 5.61 pg/mL) as were cholesterol levels (p < 0.05), with no interaction between groups. The combination of isoflavone supplementation and exercise training did not alter oxidative stress markers in postmenopausal women, but exercise training alone may increase IL-8 and decrease total cholesterol levels.

Keywords: aerobic and resistance exercises; anti-oxidant system; cytokines; menopause; soy protein.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Flowchart with the distribution of the participants in the study.
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