Is inflammation a direct response to dsDNA breaks?

Shahid Chaudhary¹, Gorantla Venkata Raghuram¹, Indraneel Mittra²

Affiliations

¹ Translational Research Laboratory, Advanced Centre for Treatment, Research and Education in Cancer, Tata Memorial Centre, Navi-Mumbai, 410210, India.
² Translational Research Laboratory, Advanced Centre for Treatment, Research and Education in Cancer, Tata Memorial Centre, Navi-Mumbai, 410210, India. Electronic address: imittra@actrec.gov.in.

PMID: 29518635
DOI: 10.1016/j.mrfmmm.2018.02.002

Is inflammation a direct response to dsDNA breaks?

Shahid Chaudhary et al. Mutat Res. 2018 Mar.

. 2018 Mar:808:48-52.

doi: 10.1016/j.mrfmmm.2018.02.002. Epub 2018 Feb 22.

Authors

Shahid Chaudhary¹, Gorantla Venkata Raghuram¹, Indraneel Mittra²

Affiliations

¹ Translational Research Laboratory, Advanced Centre for Treatment, Research and Education in Cancer, Tata Memorial Centre, Navi-Mumbai, 410210, India.
² Translational Research Laboratory, Advanced Centre for Treatment, Research and Education in Cancer, Tata Memorial Centre, Navi-Mumbai, 410210, India. Electronic address: imittra@actrec.gov.in.

PMID: 29518635
DOI: 10.1016/j.mrfmmm.2018.02.002

Abstract

Recent research shows that extra-nuclear cell-free chromatin (cfCh) released from dying cells can freely enter into healthy cells and integrate into their genomes. Genomic integration of cfCh leads to dsDNA breaks and activation of inflammatory cytokines both of which occur concurrently with similar kinetics and that induction of inflammation can be abrogated by preventing DNA breaks with the use of cfCh inactivating agents. The proposal is put forward that inflammatory cytokines are a new family of DDR proteins that are activated following dsDNA breaks inflicted by genomic integration of cfCh.

Keywords: Cell-free chromatin; DNA damage; Inflammation; NFκB; dsDNA breaks.

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Is inflammation a direct response to dsDNA breaks?

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Is inflammation a direct response to dsDNA breaks?

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