Antinuclear antibodies in autoimmune and allergic diseases
- PMID: 29491538
- PMCID: PMC5825968
- DOI: 10.5114/reum.2017.72627
Antinuclear antibodies in autoimmune and allergic diseases
Abstract
Antinuclear antibodies (ANA) are primarily significant in the diagnosis of systemic connective tissue diseases. The relationship between their occurrence in allergic diseases is poorly documented. However, the mechanism of allergic and autoimmune diseases has a common thread. In both cases, an increased production of IgE antibodies and presence of ANA in selected disease entities is observed. Equally important is the activation of basophils secreting proinflammatory factors and affecting the differentiation of TH17 lymphocytes. Both autoimmune and allergic diseases have complex multi-pathogenesis and often occur in genetically predisposed individuals. The presence of antinuclear antibodies was confirmed in many systemic connective tissue diseases and some allergic diseases. Examples include atopic dermatitis, non-allergic asthma, and pollen allergy. Co-occurring allergic and autoimmune disorders induce further search for mechanisms involved in the aetiopathogenesis of both groups of diseases.
Keywords: allergy; antinuclear antibodies; autoimmune diseases; molecular background.
Conflict of interest statement
The authors declare no conflict of interest.
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References
-
- Szczeklik A, Nizankowska E, Serafin A, et al. Autoimmune Phenomena in Bronchical Asthma with Special References to Aspirin Intolerance. Am J Respir Crit Care Med. 1995;152:1753–1756. - PubMed
-
- Comi AL, Tedeschi A, Lorini M, et al. Novel clinical and serological aspects in non-allergic asthma. Respir Med. 2007;101:2526–2533. - PubMed
-
- Asero R. Chronic idiopathic urticaria: a family study. Ann Allergy Asthma Immunol. 2002;89:195–196. - PubMed
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