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Review
. 2018 Apr;28(4):258-273.
doi: 10.1016/j.tcb.2018.01.002. Epub 2018 Feb 3.

Calcium Dynamics as a Machine for Decoding Signals

Carlotta Giorgi  1 , Alberto Danese  1 , Sonia Missiroli  1 , Simone Patergnani  1 , Paolo Pinton  2
Affiliations
Review

Calcium Dynamics as a Machine for Decoding Signals

Carlotta Giorgi et al. Trends Cell Biol. 2018 Apr.

Abstract

Calcium (Ca2+) is considered one of the most-important biological cations, because it is implicated in cell physiopathology and cell fate through a finely tuned signaling system. In support of this notion, Ca2+ is the primary driver of cell proliferation and cell growth; however, it is also intimately linked to cell death. Functional abnormalities or mutations in proteins that mediate Ca2+ homeostasis usually lead to a plethora of diseases and pathogenic states, including cancer, heart failure, diabetes, and neurodegenerative disease. In this review, we examine recent discoveries in the highly localized nature of Ca2+-dependent signal transduction and its roles in cell fate, inflammasome activation, and synaptic transmission.

Keywords: calcium; cancer; cell cycle; cell death; inflammation; ischemia; mitochondria; neuron.

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