Replication-Coupled Nucleosome Assembly in the Passage of Epigenetic Information and Cell Identity
- PMID: 29292063
- PMCID: PMC5805396
- DOI: 10.1016/j.tibs.2017.12.003
Replication-Coupled Nucleosome Assembly in the Passage of Epigenetic Information and Cell Identity
Abstract
During S phase, replicated DNA must be assembled into nucleosomes using both newly synthesized and parental histones in a process that is tightly coupled to DNA replication. This DNA replication-coupled process is regulated by multitude of histone chaperones as well as by histone-modifying enzymes. In recent years novel insights into nucleosome assembly of new H3-H4 tetramers have been gained through studies on the classical histone chaperone CAF-1 and the identification of novel factors involved in this process. Moreover, in vitro reconstitution of chromatin replication has shed light on nucleosome assembly of parental H3-H4, a process that remains elusive. Finally, recent studies have revealed that the replication-coupled nucleosome assembly is important for the determination and maintenance of cell fate in multicellular organisms.
Keywords: DNA replication; cell fate maintenance; epigenetic inheritance; histone modifications; nucleosome assembly.
Copyright © 2017 Elsevier Ltd. All rights reserved.
Figures
![Figure 1](https://cdn.statically.io/img/www.ncbi.nlm.nih.gov/pmc/articles/instance/5805396/bin/nihms928061f1.gif)
![Figure 2](https://cdn.statically.io/img/www.ncbi.nlm.nih.gov/pmc/articles/instance/5805396/bin/nihms928061f2.gif)
Similar articles
-
The Ddc1-Mec3-Rad17 sliding clamp regulates histone-histone chaperone interactions and DNA replication-coupled nucleosome assembly in budding yeast.J Biol Chem. 2014 Apr 11;289(15):10518-10529. doi: 10.1074/jbc.M114.552463. Epub 2014 Feb 25. J Biol Chem. 2014. PMID: 24573675 Free PMC article.
-
The Histone Chaperone FACT Contributes to DNA Replication-Coupled Nucleosome Assembly.Cell Rep. 2016 Feb 9;14(5):1128-1141. doi: 10.1016/j.celrep.2015.12.096. Epub 2016 Jan 21. Cell Rep. 2016. PMID: 26804921
-
RPA binds histone H3-H4 and functions in DNA replication-coupled nucleosome assembly.Science. 2017 Jan 27;355(6323):415-420. doi: 10.1126/science.aah4712. Science. 2017. PMID: 28126821
-
Histone-modifying enzymes, histone modifications and histone chaperones in nucleosome assembly: Lessons learned from Rtt109 histone acetyltransferases.Crit Rev Biochem Mol Biol. 2015 Jan-Feb;50(1):31-53. doi: 10.3109/10409238.2014.978975. Epub 2014 Nov 3. Crit Rev Biochem Mol Biol. 2015. PMID: 25365782 Free PMC article. Review.
-
All roads lead to chromatin: multiple pathways for histone deposition.Biochim Biophys Acta. 2013 Mar-Apr;1819(3-4):238-46. Biochim Biophys Acta. 2013. PMID: 24459726 Review.
Cited by
-
Reduced Levels of Lagging Strand Polymerases Shape Stem Cell Chromatin.bioRxiv [Preprint]. 2024 Apr 29:2024.04.26.591383. doi: 10.1101/2024.04.26.591383. bioRxiv. 2024. PMID: 38746451 Free PMC article. Preprint.
-
Genomic context- and H2AK119 ubiquitination-dependent inheritance of human Polycomb silencing.Sci Adv. 2024 May 10;10(19):eadl4529. doi: 10.1126/sciadv.adl4529. Epub 2024 May 8. Sci Adv. 2024. PMID: 38718120 Free PMC article.
-
DNA polymerase delta governs parental histone transfer to DNA replication lagging strand.Proc Natl Acad Sci U S A. 2024 May 14;121(20):e2400610121. doi: 10.1073/pnas.2400610121. Epub 2024 May 7. Proc Natl Acad Sci U S A. 2024. PMID: 38713623
-
Defective transfer of parental histone decreases frequency of homologous recombination by increasing free histone pools in budding yeast.Nucleic Acids Res. 2024 May 22;52(9):5138-5151. doi: 10.1093/nar/gkae205. Nucleic Acids Res. 2024. PMID: 38554108 Free PMC article.
-
Specialized replication of heterochromatin domains ensures self-templated chromatin assembly and epigenetic inheritance.Proc Natl Acad Sci U S A. 2024 Feb 6;121(6):e2315596121. doi: 10.1073/pnas.2315596121. Epub 2024 Jan 29. Proc Natl Acad Sci U S A. 2024. PMID: 38285941
References
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources