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Case Reports
. 2018 Jan;35(1):e45-e48.
doi: 10.1111/pde.13370. Epub 2017 Dec 28.

Influenza B virus infection and Stevens-Johnson syndrome

Rebecca L Tamez  1 , Whitney V Tan  2 , John T O'Malley  3 , Karen R Broder  4 , Maria C Garzon  2   5 , Philip LaRussa  5 , Christine T Lauren  2   5
Affiliations
Case Reports

Influenza B virus infection and Stevens-Johnson syndrome

Rebecca L Tamez et al. Pediatr Dermatol. 2018 Jan.

Abstract

A 2-year-old boy with influenza B infection and rapidly worsening targetoid skin lesions with mucosal involvement was diagnosed with Stevens-Johnson syndrome (SJS) and treated with oseltamivir and intravenous immunoglobulin, with resolution of illness. Subsequent quadrivalent inactivated influenza vaccine was well tolerated. This case highlights the rarity of SJS in the setting of influenza B infection and addresses the safety of administering subsequent influenza vaccines to such individuals.

Keywords: influenza vaccine; intravenous immunoglobulin; vaccine safety.

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Figures

FIGURE 1
FIGURE 1
Day of presentation: many circular pink edematous papules and small plaques with dusky violaceous centers
FIGURE 2
FIGURE 2
Skin biopsy pathology revealed necrotic keratinocytes within the epidermis and an interface dermatitis consistent with the erythema multiforme/Stevens–Johnson syndrome/toxic epidermal necrosis spectrum of inflammatory dermatoses
FIGURE 3
FIGURE 3
Day 2 of hospital course: rapidly progressing rash with more than 10% skin fragility and denudation
See this image and copyright information in PMC

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