The tension biology of wound healing
- PMID: 29105155
- DOI: 10.1111/exd.13460
The tension biology of wound healing
Abstract
Following skin wounding, the healing outcome can be: regeneration, repair with normal scar tissue, repair with hypertrophic scar tissue or the formation of keloids. The role of chemical factors in wound healing has been extensively explored, and while there is evidence suggesting the role of mechanical forces, its influence is much less well defined. Here, we provide a brief review on the recent progress of the role of mechanical force in skin wound healing by comparing laboratory mice, African spiny mice, fetal wound healing and adult scar keloid formation. A comparison across different species may provide insight into key regulators. Interestingly, some findings suggest tension can induce an immune response, and this provides a new link between mechanical and chemical forces. Clinically, manipulating skin tension has been demonstrated to be effective for scar prevention and treatment, but not for tissue regeneration. Utilising this knowledge, specialists may modulate regulatory factors and develop therapeutic strategies to reduce scar formation and promote regeneration.
Keywords: mechanobiology; regeneration; scar; tension; wound.
© 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
Similar articles
-
Endothelial dysfunction may play a key role in keloid and hypertrophic scar pathogenesis - Keloids and hypertrophic scars may be vascular disorders.Med Hypotheses. 2016 Nov;96:51-60. doi: 10.1016/j.mehy.2016.09.024. Epub 2016 Sep 28. Med Hypotheses. 2016. PMID: 27959277
-
Mechanomodulatory biomaterials prospects in scar prevention and treatment.Acta Biomater. 2022 Sep 15;150:22-33. doi: 10.1016/j.actbio.2022.07.042. Epub 2022 Jul 29. Acta Biomater. 2022. PMID: 35914694 Review.
-
Regenerative healing, scar-free healing and scar formation across the species: current concepts and future perspectives.Exp Dermatol. 2014 Sep;23(9):615-9. doi: 10.1111/exd.12457. Epub 2014 Jul 21. Exp Dermatol. 2014. PMID: 24863070 Review.
-
Soft tissue mechanotransduction in wound healing and fibrosis.Semin Cell Dev Biol. 2012 Dec;23(9):981-6. doi: 10.1016/j.semcdb.2012.09.010. Epub 2012 Oct 2. Semin Cell Dev Biol. 2012. PMID: 23036529 Review.
-
Mechanobiology of scarring.Wound Repair Regen. 2011 Sep;19 Suppl 1:s2-9. doi: 10.1111/j.1524-475X.2011.00707.x. Wound Repair Regen. 2011. PMID: 21793962
Cited by
-
Wound Management of Pediatric Burns.Semin Plast Surg. 2024 Apr 4;38(2):105-115. doi: 10.1055/s-0044-1785215. eCollection 2024 May. Semin Plast Surg. 2024. PMID: 38746700 Review.
-
Alteration of mechanical stresses in the murine brain by age and hemorrhagic stroke.PNAS Nexus. 2024 Apr 24;3(4):pgae141. doi: 10.1093/pnasnexus/pgae141. eCollection 2024 Apr. PNAS Nexus. 2024. PMID: 38659974 Free PMC article.
-
Application and effect of tension-reducing suture in surgical treatment of hypertrophic scar.BMC Surg. 2024 Apr 23;24(1):119. doi: 10.1186/s12893-024-02390-7. BMC Surg. 2024. PMID: 38654240 Free PMC article.
-
Smart Use of Skin Biopsy Punch in Treating Keloids: A Single-Center Retrospective Study.Aesthetic Plast Surg. 2024 Mar 29. doi: 10.1007/s00266-024-04000-6. Online ahead of print. Aesthetic Plast Surg. 2024. PMID: 38551710
-
Can Shockwave Treatment Elicit a Molecular Response to Enhance Clinical Outcomes in Pressure Ulcers? The SHOck Waves in wouNds Project.Biomedicines. 2024 Feb 3;12(2):359. doi: 10.3390/biomedicines12020359. Biomedicines. 2024. PMID: 38397961 Free PMC article.
Publication types
MeSH terms
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources