Alcohol's Effects on the Cardiovascular System
- PMID: 28988575
- PMCID: PMC5513687
Alcohol's Effects on the Cardiovascular System
Abstract
Alcohol use has complex effects on cardiovascular (CV) health. The associations between drinking and CV diseases such as hypertension, coronary heart disease, stroke, peripheral arterial disease, and cardiomyopathy have been studied extensively and are outlined in this review. Although many behavioral, genetic, and biologic variants influence the interconnection between alcohol use and CV disease, dose and pattern of alcohol consumption seem to modulate this most. Low-to-moderate alcohol use may mitigate certain mechanisms such as risk and hemostatic factors affecting atherosclerosis and inflammation, pathophysiologic processes integral to most CV disease. But any positive aspects of drinking must be weighed against serious physiological effects, including mitochondrial dysfunction and changes in circulation, inflammatory response, oxidative stress, and programmed cell death, as well as anatomical damage to the CV system, especially the heart itself. Both the negative and positive effects of alcohol use on particular CV conditions are presented here. The review concludes by suggesting several promising avenues for future research related to alcohol use and CV disease. These include using direct biomarkers of alcohol to confirm self-report of alcohol consumption levels; studying potential mediation of various genetic, socioeconomic, and racial and ethnic factors that may affect alcohol use and CV disease; reviewing alcohol-medication interactions in cardiac patients; and examining CV effects of alcohol use in young adults and in older adults.
Conflict of interest statement
The author declares she has no competing financial interests.
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References
-
- Administration on Aging. Aging Statistics. Washington, DC: Administration for Community Living, U.S. Department of Health and Human Services; 2014. [Accessed July 26, 2016]. Available at: http://www.aoa.acl.gov/Aging_Statistics/index.aspx.
-
- Bau PF, Bau CH, Naujorks AA, Rosito GA. Early and late effects of alcohol ingestion on blood pressure and endothelial function. Alcohol. 2005;37(1):53–58. - PubMed
-
- Beckemeier ME, Bora PS. Fatty acid ethyl esters: Potentially toxic products of myocardial ethanol metabolism. Journal of Molecular and Cellular Cardiology. 1998;30(11):2487–2494. - PubMed
-
- Bing RJ, Tillmanns H, Fauvel JM, et al. Effect of prolonged alcohol administration on calcium transport in heart muscle of the dog. Circulation Research. 1974;35(1):33–38. - PubMed
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