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Randomized Controlled Trial
. 2017 Sep 12;9(9):1002.
doi: 10.3390/nu9091002.

A Micronutrient Fortified Beverage Given at Different Dosing Frequencies Had Limited Impact on Anemia and Micronutrient Status in Filipino Schoolchildren

Imelda Angeles-Agdeppa  1 , Clarita R Magsadia  2 , Grant J Aaron  3 , Beate B Lloyd  4 , David C Hilmers  5 , Zulfiqar A Bhutta  6
Affiliations
Randomized Controlled Trial

A Micronutrient Fortified Beverage Given at Different Dosing Frequencies Had Limited Impact on Anemia and Micronutrient Status in Filipino Schoolchildren

Imelda Angeles-Agdeppa et al. Nutrients. .

Abstract

This study evaluated the effects of a multi-micronutrient fortified juice drink given in different frequencies of consumption on hemoglobin (Hb) concentration of schoolchildren. Hb was measured in 2423 schoolchildren aged 6- to 9-years-old at baseline. All anemic children (n = 246) were randomly allocated into groups: Daily dose (HD: high dose), 5X/week (MD: Moderate Dose), 3X/week (LD: Low Dose) and unfortified (Control). Pre- and post-study measurements of micronutrients were collected from 228 children. At the endpoint, significant Hb increases were observed in all groups, but there was no significant difference between groups. There was a significant reduction in anemia prevalence in all groups from 100% to 36% (Control), 30% (LD), 23% (MD) and 26% (HD). No dose-response effect was observed in Hb in this population. Most likely, this resulted from better than expected micronutrient status and lower than expected severity of anemia and micronutrient deficiencies in this cohort. It is unlikely that the addition of a fortified beverage to school feeding programs in this population would have a positive impact. Whether such an intervention would be cost-effective as a preventative approach needs to be assessed. This study demonstrates the importance of targeting such interventions to appropriate populations.

Keywords: dose response 2; hemoglobin 1; multi-nutrient fortified juice drink 3.

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Conflict of interest statement

Beate Lloyd is an affiliate of the funding agency and had a role in the design of the study and the composition of the manuscript. The authors declare no conflict of interest. The contributions of Grant J. Aaron, David Hilmers and Zulfiqar Bhutta were technical in nature and were not remunerated.

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