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Review
. 2017 Aug;3(3):166-169.
doi: 10.1159/000462981. Epub 2017 Apr 27.

A Review of the Use of Biotin for Hair Loss

Affiliations
Review

A Review of the Use of Biotin for Hair Loss

Deepa P Patel et al. Skin Appendage Disord. 2017 Aug.

Abstract

Background: Biotin has gained commercial popularity for its claimed benefits on healthy hair and nail growth. Despite its reputation, there is limited research to support the utility of biotin in healthy individuals.

Objective: To systematically review the literature on biotin efficacy in hair and nail growth.

Methods: We conducted a PubMed search of all case reports and randomized clinical trials (RCTs) using the following terms: (biotin and hair); (biotin and supplementation and hair); (biotin supplementation); (biotin and alopecia); (biotin and nails); (biotin and dermatology), and (biotin recommendations).

Results: We found 18 reported cases of biotin use for hair and nail changes. In all cases, patients receiving biotin supplementation had an underlying pathology for poor hair or nail growth. All cases showed evidence of clinical improvement after receiving biotin.

Conclusions: Though its use as a hair and nail growth supplement is prevalent, research demonstrating the efficacy of biotin is limited. In cases of acquired and inherited causes of biotin deficiency as well as pathologies, such as brittle nail syndrome or uncombable hair, biotin supplementation may be of benefit. However, we propose these cases are uncommon and that there is lack of sufficient evidence for supplementation in healthy individuals.

Keywords: Biotin; Hair; Nails; Supplement; Vitamin.

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References

    1. Institute of Medicine (US) Standing Committee on the Scientific Evaluation of Dietary Reference Intakes and Its Panel on Folate, Other B Vitamins, and Choline. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline. Washington: National Academies Press (US); 1998. - PubMed
    1. Dakshinamurti K, Triggs-Raine B. Clinical Studies in Medical Biochemistry. Oxford University Press; 1997. Biotin and Multiple Carboxylase Deficiency.
    1. Rajendiran A, Sampath S. Biotinidase deficiency - clinching the diagnosis rapidly can make all the difference! BMJ Case Reports. 2011;2011 pii:bcr0720114494. doi 10.1136/bcr.07.2011.4494. - PMC - PubMed
    1. Fujimoto W, Inaoki M, Fukui T, et al. Biotin deficiency in an infant fed with amino acid formula. J Dermatol. 2005;32:256–261. - PubMed
    1. Colamaria V, Burlina AB, Gaburro D, Pajno-Ferrara F, Saudubray JM, Merino RG, Bemardina BD. Biotin-responsive infantile encephalopathy: EEG-polygraphic study of a case. Epilepsia. 1989;30:573–578. - PubMed