Valuing health-related quality of life: An EQ-5D-5L value set for England
- PMID: 28833869
- PMCID: PMC6680214
- DOI: 10.1002/hec.3564
Valuing health-related quality of life: An EQ-5D-5L value set for England
Abstract
A new version of the EQ-5D, the EQ-5D-5L, is available. The aim of this study is to produce a value set to support use of EQ-5D-5L data in decision-making. The study design followed an international research protocol. Randomly selected members of the English general public completed 10 time trade-off and 7 discrete choice experiment tasks in face-to-face interviews. A 20-parameter hybrid model was used to combine time trade-off and discrete choice experiment data to generate values for the 3,125 EQ-5D-5L health states. Valuation data are available for 996 respondents. Face validity of the data has been demonstrated, with more severe health states generally given lower values. Problems with pain/discomfort and anxiety/depression received the greatest weight. Compared to the existing EQ-5D-3L value set, there are considerably fewer "worse than dead" states (5.1%, compared with over one third), and the minimum value is higher. Values range from -0.285 (extreme problems on all dimensions) to 0.950 (for health states 11211 and 21111). Results have important implications for users of the EQ-5D-5L both in England and internationally. Quality-adjusted life year gains from interventions seeking to improve very poor health may be smaller using this value set and may previously have been overestimated.
Keywords: EQ-5D-5L; NICE; PROMs; quality of life; stated preferences.
© 2017 The Authors. Health Economics Published by John Wiley & Sons Ltd.
Conflict of interest statement
NJD, KKS and YF are employees of the Office of Health Economics, a registered charity which received funding from a variety of sources, including the Association of the British Pharmaceutical Industry. All authors are members of the EuroQol Group.
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References
-
- Augustovski, F. , Rey‐Ares, L. , Irazola, V. , Garay, O. U. , Gianneo, O. , Fernández, G. , … Ramos‐Goñi, J. M. (2016). An EQ‐5D‐5L value set based on Uruguayan population preferences. Quality of Life Research, 25, 323–333. - PubMed
-
- Bansback, N. , Brazier, J. , Tsuchiya, A. , & Anis, A. (2012). Using a discrete choice experiment to estimate health state utility values. Journal of Health Economics, 31, 306–318. - PubMed
-
- Brazier, J. , Ratcliffe, J. , Salomon, J. A. , & Tsuchiya, A. (2017). Measuring and valuing health benefits for economic evaluation. Oxford, UK: Oxford University Press.
-
- Brazier, J. , Roberts, J. , & Deverill, M. (2002). The estimation of a preference‐based measure of health from the SF‐36. Journal of Health Economics, 21, 271–292. - PubMed
-
- CADTH [Canadian Agency for Drugs and Technologies in Health] (2006). Guidelines for the economic evaluation of health technologies: Canada [3rd edition]. Ottawa: Canadian Agency for Drugs and Technologies in Health.
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