Heart failure is associated with depletion of core intestinal microbiota
- PMID: 28772054
- PMCID: PMC5542738
- DOI: 10.1002/ehf2.12155
Heart failure is associated with depletion of core intestinal microbiota
Abstract
Aims: In spite of current medical treatment approaches, mortality of chronic heart failure (HF) remains high and novel treatment modalities are thus urgently needed. A recent theory proposes a possible impact of the intestinal microbiome on the incidence and clinical course of heart failure. This study sought to systematically investigate, if there are specific changes of the intestinal microbiome in heart failure patients.
Methods and results: The intestinal microbiome of 20 patients with heart failure with reduced ejection fraction due to ischemic or dilated cardiomyopathy was investigated by applying high-throughput sequencing of the bacterial 16S rRNA gene. Microbial profiles were compared to those of matched controls in which heart failure was ruled out by clinical assessment and NT-proBNP serum levels (n = 20). According to the Shannon diversity index (which measures the intra-individual alpha-diversity) based on the distribution of operational taxonomic units (OTUs), HF cases showed a nominally significantly lower diversity index compared to controls (Pnom. = 0.01), and testing for genera abundance showed a tendency towards a decreased alpha diversity of HF patients. Beta-diversity measures (inter-individual diversity) revealed a highly significant separation of HF cases and controls, (e.g. Pweighted UniFracv = 0.004). Assessing the individual abundance of core measurable microbiota (CMM), a significant decrease of Coriobacteriaceae, Erysipelotrichaceae and Ruminococcaceae was observed on the family level. In line with that, Blautia, Collinsella, uncl. Erysipelotrichaceae and uncl. Ruminococcaceae showed a significant decrease in HF cases compared to controls on the genus level.
Conclusions: Heart failure patients showed a significantly decreased diversity of the intestinal microbiome as well as a downregulation of key intestinal bacterial groups. Our data point to an altered intestinal microbiome as a potential player in the pathogenesis and progression of heart failure.
Keywords: 16S; Diversity; Gut microbiome; Heart failure; Microbiota.
© 2017 The Authors. ESC Heart Failure published by John Wiley & Sons Ltd on behalf of the European Society of Cardiology.
Figures
![Figure 1](https://cdn.statically.io/img/www.ncbi.nlm.nih.gov/pmc/articles/instance/5747045/bin/EHF2-4-282-g001.gif)
![Figure 2](https://cdn.statically.io/img/www.ncbi.nlm.nih.gov/pmc/articles/instance/5747045/bin/EHF2-4-282-g002.gif)
![Figure 3](https://cdn.statically.io/img/www.ncbi.nlm.nih.gov/pmc/articles/instance/5747045/bin/EHF2-4-282-g003.gif)
Similar articles
-
Gut Microbiota in Heart Failure Patients With Preserved Ejection Fraction (GUMPTION Study).Front Cardiovasc Med. 2022 Jan 6;8:803744. doi: 10.3389/fcvm.2021.803744. eCollection 2021. Front Cardiovasc Med. 2022. PMID: 35071367 Free PMC article.
-
Insights into the associations between the gut microbiome, its metabolites, and heart failure.Am J Physiol Heart Circ Physiol. 2023 Dec 1;325(6):H1325-H1336. doi: 10.1152/ajpheart.00436.2023. Epub 2023 Sep 22. Am J Physiol Heart Circ Physiol. 2023. PMID: 37737730
-
Non-Ischemic Heart Failure With Reduced Ejection Fraction Is Associated With Altered Intestinal Microbiota.Circ J. 2018 May 25;82(6):1640-1650. doi: 10.1253/circj.CJ-17-1285. Epub 2018 Mar 30. Circ J. 2018. PMID: 29607983
-
Intestinal fatty acid binding protein is associated with cardiac function and gut dysbiosis in chronic heart failure.Front Cardiovasc Med. 2023 Jun 2;10:1160030. doi: 10.3389/fcvm.2023.1160030. eCollection 2023. Front Cardiovasc Med. 2023. PMID: 37332580 Free PMC article.
-
[Analysis of the dynamic changes in gut microbiota in patients with extremely severe burns by 16S ribosomal RNA high-throughput sequencing technology].Zhonghua Shao Shang Za Zhi. 2020 Dec 20;36(12):1159-1166. doi: 10.3760/cma.j.cn501120-20200518-00271. Zhonghua Shao Shang Za Zhi. 2020. PMID: 33379852 Chinese.
Cited by
-
Role of gut microbiota in doxorubicin-induced cardiotoxicity: from pathogenesis to related interventions.J Transl Med. 2024 May 8;22(1):433. doi: 10.1186/s12967-024-05232-5. J Transl Med. 2024. PMID: 38720361 Free PMC article. Review.
-
The Role of Gut Microbiota and Its Metabolites in Patients with Heart Failure.Biomedicines. 2024 Apr 18;12(4):894. doi: 10.3390/biomedicines12040894. Biomedicines. 2024. PMID: 38672248 Free PMC article. Review.
-
The Correlation Between Heart Failure and Gut Microbiome Metabolites.Infect Microbes Dis. 2020 Nov 4;2(4):136-143. doi: 10.1097/IM9.0000000000000042. eCollection 2020 Dec. Infect Microbes Dis. 2020. PMID: 38630083 Free PMC article. Review.
-
Associations between the gut microbiome, gut microbiology and heart failure: Current understanding and future directions.Am Heart J Plus. 2022 Jun 11;17:100150. doi: 10.1016/j.ahjo.2022.100150. eCollection 2022 May. Am Heart J Plus. 2022. PMID: 38559891 Free PMC article. Review.
-
Potential Impact of a Pregnant Woman's Microbiota on the Development of Fetal Heart Defects: A Review of the Literature.Biomedicines. 2024 Mar 14;12(3):654. doi: 10.3390/biomedicines12030654. Biomedicines. 2024. PMID: 38540267 Free PMC article. Review.
References
-
- Yancy CW, Jessup M, Bozkurt B, Butler J, Casey DE Jr, Drazner MH, Fonarow GC, Geraci SA, Horwich T, Januzzi JL, Johnson MR, Kasper EK, Levy WC, Masoudi FA, McBride PE, McMurray JJ, Mitchell JE, Peterson PN, Riegel B, Sam F, Stevenson LW, Tang WH, Tsai EJ, Wilkoff BL. 2013 ACCF/AHA guideline for the management of heart failure: a report of the American College of Cardiology Foundation/American Heart Association Task Force on practice guidelines. Circulation 2013; 128: e240–e327. - PubMed
-
- Go AS, Mozaffarian D, Roger VL, Benjamin EJ, Berry JD, Blaha MJ, Dai S, Ford ES, Fox CS, Franco S, Fullerton HJ, Gillespie C, Hailpern SM, Heit JA, Howard VJ, Huffman MD, Judd SE, Kissela BM, Kittner SJ, Lackland DT, Lichtman JH, Lisabeth LD, Mackey RH, Magid DJ, Marcus GM, Marelli A, Matchar DB, McGuire DK, Mohler ER 3rd, Moy CS, Mussolino ME, Neumar RW, Nichol G, Pandey DK, Paynter NP, Reeves MJ, Sorlie PD, Stein J, Towfighi A, Turan TN, Virani SS, Wong ND, Woo D, Turner MB. Heart disease and stroke statistics‐‐2014 update: a report from the American Heart Association. Circulation 2014; 129: e28–e292. - PMC - PubMed
-
- Warriner D, Sheridan P, Lawford P. Heart failure: not a single organ disease but a multisystem syndrome. Br J Hosp Med (London, England : 2005) 2015; 76: 330–336. - PubMed
LinkOut - more resources
Full Text Sources
Other Literature Sources
Research Materials
Miscellaneous