Review

. 2017 Sep;19(9):59.

doi: 10.1007/s11912-017-0617-2.

Pathology of Neuroendocrine Tumours of the Female Genital Tract

Brooke E Howitt¹, Paul Kelly^{2

3}, W Glenn McCluggage^{4

5}

Affiliations

¹ Department of Pathology, Division of Women's and Perinatal Pathology, Brigham and Women's Hospital, Boston, MA, 02115, USA.
² Department of Pathology, Belfast Health and Social Care Trust, Belfast, UK.
³ Department of Pathology, Royal Group of Hospitals Trust, Grosvenor Road, Belfast, BT12 6BA, UK.
⁴ Department of Pathology, Belfast Health and Social Care Trust, Belfast, UK. glenn.mccluggage@belfasttrust.hscni.net.
⁵ Department of Pathology, Royal Group of Hospitals Trust, Grosvenor Road, Belfast, BT12 6BA, UK. glenn.mccluggage@belfasttrust.hscni.net.

PMID: 28735441
DOI: 10.1007/s11912-017-0617-2

Review

Pathology of Neuroendocrine Tumours of the Female Genital Tract

Brooke E Howitt et al. Curr Oncol Rep. 2017 Sep.

. 2017 Sep;19(9):59.

doi: 10.1007/s11912-017-0617-2.

Authors

Brooke E Howitt¹, Paul Kelly^{2

3}, W Glenn McCluggage^{4

5}

Affiliations

¹ Department of Pathology, Division of Women's and Perinatal Pathology, Brigham and Women's Hospital, Boston, MA, 02115, USA.
² Department of Pathology, Belfast Health and Social Care Trust, Belfast, UK.
³ Department of Pathology, Royal Group of Hospitals Trust, Grosvenor Road, Belfast, BT12 6BA, UK.
⁴ Department of Pathology, Belfast Health and Social Care Trust, Belfast, UK. glenn.mccluggage@belfasttrust.hscni.net.
⁵ Department of Pathology, Royal Group of Hospitals Trust, Grosvenor Road, Belfast, BT12 6BA, UK. glenn.mccluggage@belfasttrust.hscni.net.

PMID: 28735441
DOI: 10.1007/s11912-017-0617-2

Abstract

Neuroendocrine tumours are uncommon or rare at all sites in the female genital tract. The 2014 World Health Organisation (WHO) Classification of neuroendocrine tumours of the endometrium, cervix, vagina and vulva has been updated with adoption of the terms low-grade neuroendocrine tumour and high-grade neuroendocrine carcinoma. In the endometrium and cervix, high-grade neoplasms are much more prevalent than low-grade and are more common in the cervix than the corpus. In the ovary, low-grade tumours are more common than high-grade carcinomas and the term carcinoid tumour is still used in WHO 2014. The term ovarian small-cell carcinoma of pulmonary type is included in WHO 2014 for a tumour which in other organs is termed high small-cell neuroendocrine carcinoma. Neuroendocrine tumours at various sites within the female genital tract often occur in association with other neoplasms and more uncommonly in pure form.

Keywords: Cervix; Endometrium; Immunohistochemistry; Neuroendocrine carcinoma; Neuroendocrine tumour; Ovary; Uterus.

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Pathology of Neuroendocrine Tumours of the Female Genital Tract

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Pathology of Neuroendocrine Tumours of the Female Genital Tract

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