Obsessive-compulsive disorder, which genes? Which functions? Which pathways? An integrated holistic view regarding OCD and its complex genetic etiology
- PMID: 28608743
- DOI: 10.1080/01677063.2017.1336236
Obsessive-compulsive disorder, which genes? Which functions? Which pathways? An integrated holistic view regarding OCD and its complex genetic etiology
Abstract
Obsessive-compulsive disorder (OCD) is characterized by recurrent obtrusive and repetitive acts typically occurred following anxiety. In the last two decades, studies done on the gene sequences, large-scale and point mutations and gene-gene, gene-environment and gene-drug interactions have led to the discovery of hundreds of genes associated with OCD. Although each gene in turn is a part of the etiology of this disorder; however, OCD, like other mental disorders is complex and a comprehensive and integrated view is necessary to understand its genetic basis. In this study, through an extensive review of existing published studies, all genes associated with OCD were found. Then, in order to integrate the results, all the interactions between these genes were explored and the achievement was represented as an interactive genetic network. Furthermore, the reconstructed network was analyzed. It was found that GRIN2A, GRIN2B and GRIA2 are the most central nodes in the network. Functional and pathway enrichment analysis showed that glutamate-related pathways are the main deficient systems in patients with OCD. By studying genes shared between OCD and other diseases, it was cleared that OCD, epilepsy and some types of cancer have the most number of shared genes. The results of this study, in addition to reviewing the available results as a comprehensive and integrated manner, provide new hypotheses for future studies.
Keywords: Obsessive–compulsive disorder; functional enrichment analysis; gene; genetic network; pathway enrichment analysis.
Similar articles
-
Association between the NMDA glutamate receptor GRIN2B gene and obsessive-compulsive disorder.J Psychiatry Neurosci. 2012 Jul;37(4):273-81. doi: 10.1503/jpn.110109. J Psychiatry Neurosci. 2012. PMID: 22433450 Free PMC article.
-
Integrative analysis of shared genetic pathogenesis by autism spectrum disorder and obsessive-compulsive disorder.Biosci Rep. 2019 Dec 20;39(12):BSR20191942. doi: 10.1042/BSR20191942. Biosci Rep. 2019. PMID: 31808517 Free PMC article.
-
Integrative analysis of shared genetic pathogenesis by obsessive‑compulsive and eating disorders.Mol Med Rep. 2019 Mar;19(3):1761-1766. doi: 10.3892/mmr.2018.9772. Epub 2018 Dec 17. Mol Med Rep. 2019. PMID: 30569105
-
An integrated molecular landscape implicates the regulation of dendritic spine formation through insulin-related signalling in obsessive-compulsive disorder.J Psychiatry Neurosci. 2016 Jun;41(4):280-5. doi: 10.1503/jpn.140327. J Psychiatry Neurosci. 2016. PMID: 26854754 Free PMC article. Review.
-
Genetics of obsessive-compulsive disorders: new findings and challenges.Brain Dev. 2003 Dec;25 Suppl 1:S55-61. doi: 10.1016/s0387-7604(03)90010-6. Brain Dev. 2003. PMID: 14980374 Review.
Cited by
-
Reduced Expression of the Htr2a, Grin1, and Bdnf Genes and Cognitive Inflexibility in a Model of High Compulsive Rats.Mol Neurobiol. 2023 Dec;60(12):6975-6991. doi: 10.1007/s12035-023-03506-5. Epub 2023 Jul 31. Mol Neurobiol. 2023. PMID: 37523044
-
Therapies for obsessive-compulsive disorder: Current state of the art and perspectives for approaching treatment-resistant patients.Front Psychiatry. 2023 Feb 16;14:1065812. doi: 10.3389/fpsyt.2023.1065812. eCollection 2023. Front Psychiatry. 2023. PMID: 36873207 Free PMC article. Review.
-
Neurogenetics of Dynamic Connectivity Patterns Associated With Obsessive-Compulsive Symptoms in Healthy Children.Biol Psychiatry Glob Open Sci. 2021 Nov 27;2(4):411-420. doi: 10.1016/j.bpsgos.2021.11.009. eCollection 2022 Oct. Biol Psychiatry Glob Open Sci. 2021. PMID: 36324658 Free PMC article.
-
Efficacy of group cognitive-behavioral therapy in adolescents with obsessive compulsive disorder: a systematic review and meta-analysis.Braz J Psychiatry. 2022 Jun 23;44(4):449-60. doi: 10.47626/1516-4446-2021-2264. Online ahead of print. Braz J Psychiatry. 2022. PMID: 35749639 Free PMC article.
-
The Relationship Between Trauma Exposure and Obsessive-Compulsive Disorder in Youth: A Systematic Review.Child Psychiatry Hum Dev. 2023 Dec;54(6):1624-1652. doi: 10.1007/s10578-022-01352-5. Epub 2022 Apr 29. Child Psychiatry Hum Dev. 2023. PMID: 35488083
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Miscellaneous