A review of the role of serotonin system genes in obsessive-compulsive disorder
- PMID: 28576508
- DOI: 10.1016/j.neubiorev.2017.05.029
A review of the role of serotonin system genes in obsessive-compulsive disorder
Abstract
Obsessive-compulsive disorder (OCD) is a debilitating neuropsychiatric disorder that causes the patient to experience intrusive thoughts and/or to carry out repetitive, ritualized behaviors that are time consuming and impairing. OCD is familial and heritable. The genetic factors responsible for pathogenesis, however, remain largely unknown despite the numerous candidate gene studies conducted. Based on efficacy of serotonin reuptake inhibitors (SRIs) in treating OCD, serotonin system genes have been a dominant focus in OCD candidate gene studies. We review the most commonly studied candidate serotonin system gene variants (specifically in SLC6A4, HTR2A, HTR1B, and HTR2C) and their association with OCD. Although findings to date are mixed, serotonin transporter polymorphism 5-HTTLPR and HTR2A polymorphism rs6311 (or rs6313) are most consistently associated with OCD. Mixed findings may be the result of genetic complexity and phenotypic heterogeneity that future studies should account for. Homogenous patient subgroups reflecting OCD symptom dimensions, OCD subtypes, and sex should be used for gene discovery.
Keywords: 5-HT1B; 5-HT2A; 5-HT2C; 5-HTTLPR; Candidate gene; Genetic association; Genetics; HTR1B; HTR2A; HTR2C; Neuropsychiatry; Neuroscience; OCD; Obsessive-compulsive disorder; Psychiatry; SLC6A4; Serotonin system; Serotonin transporter; Subtypes; Symptom dimensions.
Copyright © 2017 Elsevier Ltd. All rights reserved.
Similar articles
-
Serotonin system genes and obsessive-compulsive trait dimensions in a population-based, pediatric sample: a genetic association study.J Child Psychol Psychiatry. 2019 Dec;60(12):1289-1299. doi: 10.1111/jcpp.13079. Epub 2019 Jul 19. J Child Psychol Psychiatry. 2019. PMID: 31321769
-
Association analysis of SLC6A4 and HTR2A genes with obsessive-compulsive disorder: Influence of the STin2 polymorphism.Compr Psychiatry. 2018 Apr;82:1-6. doi: 10.1016/j.comppsych.2017.12.004. Epub 2017 Dec 16. Compr Psychiatry. 2018. PMID: 29331882
-
Association studies of serotonin system candidate genes in early-onset obsessive-compulsive disorder.Biol Psychiatry. 2007 Feb 1;61(3):322-9. doi: 10.1016/j.biopsych.2006.09.030. Biol Psychiatry. 2007. PMID: 17241828
-
The association of HTR2A polymorphisms with obsessive-compulsive disorder and its subtypes: A meta-analysis.J Affect Disord. 2020 Oct 1;275:278-289. doi: 10.1016/j.jad.2020.06.016. Epub 2020 Jun 23. J Affect Disord. 2020. PMID: 32734920 Review.
-
Is serotonin transporter polymorphism (5-HTTLPR) allele status a predictor for obsessive-compulsive disorder? A meta-analysis.Arch Womens Ment Health. 2015 Jun;18(3):435-45. doi: 10.1007/s00737-015-0526-z. Epub 2015 Apr 21. Arch Womens Ment Health. 2015. PMID: 25896187 Review.
Cited by
-
Risk and Resilience Variants in the Retinoic Acid Metabolic and Developmental Pathways Associated with Risk of FASD Outcomes.Biomolecules. 2024 May 10;14(5):569. doi: 10.3390/biom14050569. Biomolecules. 2024. PMID: 38785976 Free PMC article.
-
Can miRNA Expression Levels Predict Treatment Resistance to Serotonin Reuptake Inhibitors in Patients with Obsessive-Compulsive Disorder?Psychiatry Clin Psychopharmacol. 2022 Jun 1;32(2):98-106. doi: 10.5152/pcp.2022.22391. eCollection 2022 Jun. Psychiatry Clin Psychopharmacol. 2022. PMID: 38764867 Free PMC article.
-
The Benzoylpiperidine Fragment as a Privileged Structure in Medicinal Chemistry: A Comprehensive Review.Molecules. 2024 Apr 23;29(9):1930. doi: 10.3390/molecules29091930. Molecules. 2024. PMID: 38731421 Free PMC article. Review.
-
The Oxidative Status and Na+/K+-ATPase Activity in Obsessive-Compulsive Disorder: A Case Control Study.Biomed Res Int. 2024 Feb 23;2024:9979582. doi: 10.1155/2024/9979582. eCollection 2024. Biomed Res Int. 2024. PMID: 38435539 Free PMC article.
-
BDNF, DRD4, and HTR2A Gene Allele Frequency Distribution and Association with Mental Illnesses in the European Part of Russia.Genes (Basel). 2024 Feb 14;15(2):240. doi: 10.3390/genes15020240. Genes (Basel). 2024. PMID: 38397229 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical