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. 2017 Apr 28;59(1):25.
doi: 10.1186/s13028-017-0294-z.

Disseminated hyaline ring granuloma in the omentum of a dog

Izabella Dolka  1 , Anna Gruk-Jurka  2 , Piotr Jurka  2 , Beata Dolka  3 , Joanna Bonecka  2
Affiliations

Disseminated hyaline ring granuloma in the omentum of a dog

Izabella Dolka et al. Acta Vet Scand. .

Abstract

Background: Hyaline ring granuloma (HRG) is an uncommon histopathologic finding of unsolved etiopathogenesis. According to the exogenous theory, HRG develops due to implantation of foreign material, most probably indigestible plant fragments. HRG is a comparatively rare condition in humans, mostly involving the oral cavity with very rare extraoral locations.

Case presentation: An 1-year-old mixed-breed dog in good condition was presented for routine ovariohysterectomy. Disseminated HGR were accidentally found in the omental adipose tissue during surgery. Histopathology revealed the presence of ring-like hyaline structures surrounded by granulomatous inflammation including foreign body-type multinucleated giant cells. The histochemical examinations indicated the exogenous plant origin of the foreign material.

Conclusions: The lesions were similar to the findings in humans with HRG. The definitive diagnosis remains largely based on histopathological examination supported by special histochemical stains. To the best of our knowledge, this is the first case of hyaline ring granuloma reported in a non-human species. Moreover, the omentum is an uncommon location for this condition.

Keywords: Dog; Histopathology; Hyaline ring granuloma; Pulse granuloma.

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Figures

Fig. 1
Fig. 1
Photomicrographs of hyaline ring granulomas. a Small lesions disseminated in the omental adipose tissue. HE, bar 200 μm. b Corrugated, eosinophilic structures (hyaline rings) associated with inflammatory cell infiltrate entrapment within the rings. HE, bar 20 μm. c Presence of foreign material, most likely of plant origin, surrounded by hyaline rings (arrows) and chronic granulomatous inflammation with multinucleated foreign-body type giant cells reaction (arrowheads). HE, bar 20 μm. d Plant internal structure characterized by the presence of thin-walled cells forming a honeycomb structure suggestive of phloem, and tubular structures resembling tracheids in the xylem with the appearance of microscopic coils (thin arrows). Implanted plant particles are associated with hyaline rings (arrow) and multinucleated giant cell (arrowhead). HE, bar 20 μm
Fig. 2
Fig. 2
Photomicrographs of sections stained with selected histochemical methods and microscopy in polarized light for the visualization of hyaline ring granulomas in the omental adipose tissue. a PAS-positive staining of plant matter (arrowhead) and hyaline structures (arrow) surrounded by the connective and adipose tissues. PAS, bar 50 μm. b Most hyaline ring-like structures stained blue with alcian blue. Bar 20 μm. Insets plant cells stained blue, partially lignified and stained magenta by AB. Bar 20 μm. c PAS-positive diastase-resistant staining (PASD) of plant material (arrowhead) associated with the presence of cellulose and hyaline structures (arrow). Bar 50 μm. d Plant particles showing birefringence under polarized light. The same plant structure is presented in Fig. 1d. Bar 20 μm
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