Mycosis Fungoides and Sezary Syndrome
- PMID: 28340880
- DOI: 10.1016/j.hoc.2016.11.008
Mycosis Fungoides and Sezary Syndrome
Abstract
Mycosis fungoides and the Sezary syndrome (SS) are rare lymphomas of CD4+ helper T cells. There is stagewise progression from patch/plaques to thicker tumor lesions/diffuse erythroderma. Blood involvement is a characteristic of SS. Outcomes are related to the extent of skin, blood, lymph node, and visceral organ involvement. Patients with limited patch and plaque disease are treated with skin-directed therapies. More advanced/refractory disease is treated with skin-directed therapies and oral or systemic immunomodulatory agents. Single-agent chemotherapies are used against tumors, refractory plaques, and lymph node and visceral involvement. Allogeneic stem cell transplantation is a potentially curative strategy for advanced/resistant disease.
Keywords: Allogeneic stem cell transplantation; Immunotherapy; Mycosis fungoides; Sezary syndrome; T-cell lymphoma.
Copyright © 2016 Elsevier Inc. All rights reserved.
Similar articles
-
Primary cutaneous T-cell lymphoma (mycosis fungoides and Sézary syndrome): part II. Prognosis, management, and future directions.J Am Acad Dermatol. 2014 Feb;70(2):223.e1-17; quiz 240-2. doi: 10.1016/j.jaad.2013.08.033. J Am Acad Dermatol. 2014. PMID: 24438970 Review.
-
Mycosis fungoides and the Sézary syndrome: pathology, staging, and treatment.Curr Probl Cancer. 1990 Nov-Dec;14(6):293-371. doi: 10.1016/0147-0272(90)90018-l. Curr Probl Cancer. 1990. PMID: 2245651 Review.
-
Allogeneic hematopoietic stem cell transplantation for refractory mycosis fungoides (MF) and Sezary syndrome (SS).Int J Hematol. 2017 Sep;106(3):426-430. doi: 10.1007/s12185-017-2245-x. Epub 2017 May 2. Int J Hematol. 2017. PMID: 28466385
-
New aspects of the clinicopathological features and treatment of mycosis fungoides and Sézary syndrome.J Dermatol. 2015 Oct;42(10):941-4. doi: 10.1111/1346-8138.13083. J Dermatol. 2015. PMID: 26432429 Review.
-
Histopathologic staging at initial diagnosis of mycosis fungoides and the Sézary syndrome. Definition of three distinctive prognostic groups.Ann Intern Med. 1988 Sep 1;109(5):372-82. doi: 10.7326/0003-4819-109-5-372. Ann Intern Med. 1988. PMID: 3408055
Cited by
-
In vivo Dosimetry for Dose Verification of Total Skin Electron Beam Therapy Using Gafchromic® EBT3 Film Dosimetry.J Med Phys. 2022 Oct-Dec;47(4):362-366. doi: 10.4103/jmp.jmp_72_22. Epub 2023 Jan 10. J Med Phys. 2022. PMID: 36908494 Free PMC article.
-
Lack of PRAME Expression in Cutaneous T-Cell Lymphomas.Dermatopathology (Basel). 2021 Dec 31;9(1):11-16. doi: 10.3390/dermatopathology9010002. Dermatopathology (Basel). 2021. PMID: 35076507 Free PMC article.
-
PEG10 amplification at 7q21.3 potentiates large-cell transformation in cutaneous T-cell lymphoma.Blood. 2022 Jan 27;139(4):554-571. doi: 10.1182/blood.2021012091. Blood. 2022. PMID: 34582557 Free PMC article.
-
Mycosis fungoides of the vulva.North Clin Istanb. 2020 Nov 23;8(1):101-105. doi: 10.14744/nci.2020.12129. eCollection 2021. North Clin Istanb. 2020. PMID: 33623880 Free PMC article.
-
Perphenazine exerts antitumor effects on HUT78 cells through Akt dephosphorylation by protein phosphatase 2A.Oncol Lett. 2021 Feb;21(2):113. doi: 10.3892/ol.2020.12374. Epub 2020 Dec 15. Oncol Lett. 2021. PMID: 33376545 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Research Materials
