Multifarious Beneficial Effect of Nonessential Amino Acid, Glycine: A Review
- PMID: 28337245
- PMCID: PMC5350494
- DOI: 10.1155/2017/1716701
Multifarious Beneficial Effect of Nonessential Amino Acid, Glycine: A Review
Erratum in
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Corrigendum to "Multifarious Beneficial Effect of Nonessential Amino Acid, Glycine: A Review".Oxid Med Cell Longev. 2022 Feb 23;2022:9857645. doi: 10.1155/2022/9857645. eCollection 2022. Oxid Med Cell Longev. 2022. PMID: 35251485 Free PMC article.
Abstract
Glycine is most important and simple, nonessential amino acid in humans, animals, and many mammals. Generally, glycine is synthesized from choline, serine, hydroxyproline, and threonine through interorgan metabolism in which kidneys and liver are the primarily involved. Generally in common feeding conditions, glycine is not sufficiently synthesized in humans, animals, and birds. Glycine acts as precursor for several key metabolites of low molecular weight such as creatine, glutathione, haem, purines, and porphyrins. Glycine is very effective in improving the health and supports the growth and well-being of humans and animals. There are overwhelming reports supporting the role of supplementary glycine in prevention of many diseases and disorders including cancer. Dietary supplementation of proper dose of glycine is effectual in treating metabolic disorders in patients with cardiovascular diseases, several inflammatory diseases, obesity, cancers, and diabetes. Glycine also has the property to enhance the quality of sleep and neurological functions. In this review we will focus on the metabolism of glycine in humans and animals and the recent findings and advances about the beneficial effects and protection of glycine in different disease states.
Conflict of interest statement
The authors declare that they have no competing interests.
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