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Review
. 2017 Feb 25;2(2):CD009275.
doi: 10.1002/14651858.CD009275.pub3.

Different types of dietary advice for women with gestational diabetes mellitus

Affiliations
Review

Different types of dietary advice for women with gestational diabetes mellitus

Shanshan Han et al. Cochrane Database Syst Rev. .

Abstract

Background: Dietary advice is the main strategy for managing gestational diabetes mellitus (GDM). It remains unclear what type of advice is best.

Objectives: To assess the effects of different types of dietary advice for women with GDM for improving health outcomes for women and babies.

Search methods: We searched Cochrane Pregnancy and Childbirth's Trials Register (8 March 2016), PSANZ's Trials Registry (22 March 2016) and reference lists of retrieved studies.

Selection criteria: Randomised controlled trials comparing the effects of different types of dietary advice for women with GDM.

Data collection and analysis: Two authors independently assessed study eligibility, risk of bias, and extracted data. Evidence quality for two comparisons was assessed using GRADE, for primary outcomes for the mother: hypertensive disorders of pregnancy; caesarean section; type 2 diabetes mellitus; and child: large-for-gestational age; perinatal mortality; neonatal mortality or morbidity composite; neurosensory disability; secondary outcomes for the mother: induction of labour; perineal trauma; postnatal depression; postnatal weight retention or return to pre-pregnancy weight; and child: hypoglycaemia; childhood/adulthood adiposity; childhood/adulthood type 2 diabetes mellitus.

Main results: In this update, we included 19 trials randomising 1398 women with GDM, at an overall unclear to moderate risk of bias (10 comparisons). For outcomes assessed using GRADE, downgrading was based on study limitations, imprecision and inconsistency. Where no findings are reported below for primary outcomes or pre-specified GRADE outcomes, no data were provided by included trials. Primary outcomes Low-moderate glycaemic index (GI) versus moderate-high GI diet (four trials): no clear differences observed for: large-for-gestational age (risk ratio (RR) 0.71, 95% confidence interval (CI) 0.22 to 2.34; two trials, 89 infants; low-quality evidence); severe hypertension or pre-eclampsia (RR 1.02, 95% CI 0.07 to 15.86; one trial, 95 women; very low-quality evidence); eclampsia (RR 0.34, 95% CI 0.01 to 8.14; one trial, 83 women; very low-quality evidence) or caesarean section (RR 0.66, 95% CI 0.29 to 1.47; one trial, 63 women; low-quality evidence). Energy-restricted versus no energy-restricted diet (three trials): no clear differences seen for: large-for-gestational age (RR 1.17, 95% CI 0.65 to 2.12; one trial, 123 infants; low-quality evidence); perinatal mortality (no events; two trials, 423 infants; low-quality evidence); pre-eclampsia (RR 1.00, 95% CI 0.51 to 1.97; one trial, 117 women; low-quality evidence); or caesarean section (RR 1.12, 95% CI 0.80 to 1.56; two trials, 420 women; low-quality evidence). DASH (Dietary Approaches to Stop Hypertension) diet versus control diet (three trials): no clear differences observed for: pre-eclampsia (RR 1.00, 95% CI 0.31 to 3.26; three trials, 136 women); however there were fewer caesarean sections in the DASH diet group (RR 0.53, 95% CI 0.37 to 0.76; two trials, 86 women). Low-carbohydrate versus high-carbohydrate diet (two trials): no clear differences seen for: large-for-gestational age (RR 0.51, 95% CI 0.13 to 1.95; one trial, 149 infants); perinatal mortality (RR 3.00, 95% CI 0.12 to 72.49; one trial, 150 infants); maternal hypertension (RR 0.40, 95% CI 0.13 to 1.22; one trial, 150 women); or caesarean section (RR 1.29, 95% CI 0.84 to 1.99; two trials, 179 women). High unsaturated fat versus low unsaturated fat diet (two trials): no clear differences observed for: large-for-gestational age (RR 0.54, 95% CI 0.21 to 1.37; one trial, 27 infants); pre-eclampsia (no cases; one trial, 27 women); hypertension in pregnancy (RR 0.54, 95% CI 0.06 to 5.26; one trial, 27 women); caesarean section (RR 1.08, 95% CI 0.07 to 15.50; one trial, 27 women); diabetes at one to two weeks (RR 2.00, 95% CI 0.45 to 8.94; one trial, 24 women) or four to 13 months postpartum (RR 1.00, 95% CI 0.10 to 9.61; one trial, six women). Low-GI versus high-fibre moderate-GI diet (one trial): no clear differences seen for: large-for-gestational age (RR 2.87, 95% CI 0.61 to 13.50; 92 infants); caesarean section (RR 1.91, 95% CI 0.91 to 4.03; 92 women); or type 2 diabetes at three months postpartum (RR 0.76, 95% CI 0.11 to 5.01; 58 women). Diet recommendation plus diet-related behavioural advice versus diet recommendation only (one trial): no clear differences observed for: large-for-gestational age (RR 0.73, 95% CI 0.25 to 2.14; 99 infants); or caesarean section (RR 0.78, 95% CI 0.38 to 1.62; 99 women). Soy protein-enriched versus no soy protein diet (one trial): no clear differences seen for: pre-eclampsia (RR 2.00, 95% CI 0.19 to 21.03; 68 women); or caesarean section (RR 1.00, 95% CI 0.57 to 1.77; 68 women). High-fibre versus standard-fibre diet (one trial): no primary outcomes reported. Ethnic-specific versus standard healthy diet (one trial): no clear differences observed for: large-for-gestational age (RR 0.14, 95% CI 0.01 to 2.45; 20 infants); neonatal composite adverse outcome (no events; 20 infants); gestational hypertension (RR 0.33, 95% CI 0.02 to 7.32; 20 women); or caesarean birth (RR 1.20, 95% CI 0.54 to 2.67; 20 women). Secondary outcomes For secondary outcomes assessed using GRADE no differences were observed: between a low-moderate and moderate-high GI diet for induction of labour (RR 0.88, 95% CI 0.33 to 2.34; one trial, 63 women; low-quality evidence); or an energy-restricted and no energy-restricted diet for induction of labour (RR 1.02, 95% CI 0.68 to 1.53; one trial, 114 women, low-quality evidence) and neonatal hypoglycaemia (average RR 1.06, 95% CI 0.48 to 2.32; two trials, 408 infants; very low-quality evidence).Few other clear differences were observed for reported outcomes. Longer-term health outcomes and health services use and costs were largely not reported.

Authors' conclusions: Evidence from 19 trials assessing different types of dietary advice for women with GDM suggests no clear differences for primary outcomes and secondary outcomes assessed using GRADE, except for a possible reduction in caesarean section for women receiving a DASH diet compared with a control diet. Few differences were observed for secondary outcomes.Current evidence is limited by the small number of trials in each comparison, small sample sizes, and variable methodological quality. More evidence is needed to assess the effects of different types of dietary advice for women with GDM. Future trials should be adequately powered to evaluate short- and long-term outcomes.

PubMed Disclaimer

Conflict of interest statement

Shanshan Han: none known.

Philippa Middleton: none known.

Emily Shepherd: none known.

Emer Van Ryswyk: none known.

Caroline A Crowther: none known.

Figures

1
1
Study flow diagram.
2
2
'Risk of bias' graph: review authors' judgements about each risk of bias item presented as percentages across all included studies.
3
3
'Risk of bias' summary: review authors' judgements about each risk of bias item for each included study.
1.1
1.1. Analysis
Comparison 1 Low‐moderate GI diet versus moderate‐high GI diet, Outcome 1 Large‐for‐gestational age.
1.2
1.2. Analysis
Comparison 1 Low‐moderate GI diet versus moderate‐high GI diet, Outcome 2 Hypertensive disorders of pregnancy (severe hypertension or pre‐eclampsia).
1.3
1.3. Analysis
Comparison 1 Low‐moderate GI diet versus moderate‐high GI diet, Outcome 3 Hypertensive disorders of pregnancy (eclampsia).
1.4
1.4. Analysis
Comparison 1 Low‐moderate GI diet versus moderate‐high GI diet, Outcome 4 Caesarean section.
1.5
1.5. Analysis
Comparison 1 Low‐moderate GI diet versus moderate‐high GI diet, Outcome 5 Gestational age at birth (weeks).
1.6
1.6. Analysis
Comparison 1 Low‐moderate GI diet versus moderate‐high GI diet, Outcome 6 Preterm birth.
1.7
1.7. Analysis
Comparison 1 Low‐moderate GI diet versus moderate‐high GI diet, Outcome 7 Macrosomia.
1.8
1.8. Analysis
Comparison 1 Low‐moderate GI diet versus moderate‐high GI diet, Outcome 8 Small‐for‐gestational age.
1.9
1.9. Analysis
Comparison 1 Low‐moderate GI diet versus moderate‐high GI diet, Outcome 9 Birthweight (g).
1.10
1.10. Analysis
Comparison 1 Low‐moderate GI diet versus moderate‐high GI diet, Outcome 10 Head circumference at birth (cm).
1.11
1.11. Analysis
Comparison 1 Low‐moderate GI diet versus moderate‐high GI diet, Outcome 11 Length at birth (cm).
1.12
1.12. Analysis
Comparison 1 Low‐moderate GI diet versus moderate‐high GI diet, Outcome 12 Ponderal index at birth (kg/m³).
1.13
1.13. Analysis
Comparison 1 Low‐moderate GI diet versus moderate‐high GI diet, Outcome 13 Normal vaginal birth.
1.14
1.14. Analysis
Comparison 1 Low‐moderate GI diet versus moderate‐high GI diet, Outcome 14 Operative vaginal birth.
1.15
1.15. Analysis
Comparison 1 Low‐moderate GI diet versus moderate‐high GI diet, Outcome 15 Induction of labour.
1.16
1.16. Analysis
Comparison 1 Low‐moderate GI diet versus moderate‐high GI diet, Outcome 16 Postpartum haemorrhage.
1.17
1.17. Analysis
Comparison 1 Low‐moderate GI diet versus moderate‐high GI diet, Outcome 17 Postpartum infection.
1.18
1.18. Analysis
Comparison 1 Low‐moderate GI diet versus moderate‐high GI diet, Outcome 18 Gestational weight gain (kg).
1.19
1.19. Analysis
Comparison 1 Low‐moderate GI diet versus moderate‐high GI diet, Outcome 19 Use of additional pharmacotherapy.
1.20
1.20. Analysis
Comparison 1 Low‐moderate GI diet versus moderate‐high GI diet, Outcome 20 Glycaemic control: end of intervention fasting plasma glucose (mmol/L).
1.21
1.21. Analysis
Comparison 1 Low‐moderate GI diet versus moderate‐high GI diet, Outcome 21 Glycaemic control: end of intervention 2‐hour postprandial glucose (mmol/L).
1.22
1.22. Analysis
Comparison 1 Low‐moderate GI diet versus moderate‐high GI diet, Outcome 22 Glycaemic control: end of intervention HbA1c (%).
2.1
2.1. Analysis
Comparison 2 Energy‐restricted diet versus no energy‐restricted diet, Outcome 1 Large‐for‐gestational age.
2.2
2.2. Analysis
Comparison 2 Energy‐restricted diet versus no energy‐restricted diet, Outcome 2 Perinatal mortality (stillbirth and neonatal mortality).
2.3
2.3. Analysis
Comparison 2 Energy‐restricted diet versus no energy‐restricted diet, Outcome 3 Hypertensive disorders of pregnancy: pre‐eclampsia.
2.4
2.4. Analysis
Comparison 2 Energy‐restricted diet versus no energy‐restricted diet, Outcome 4 Caesarean section.
2.5
2.5. Analysis
Comparison 2 Energy‐restricted diet versus no energy‐restricted diet, Outcome 5 Stillbirth.
2.6
2.6. Analysis
Comparison 2 Energy‐restricted diet versus no energy‐restricted diet, Outcome 6 Neonatal mortality.
2.7
2.7. Analysis
Comparison 2 Energy‐restricted diet versus no energy‐restricted diet, Outcome 7 Gestational age at birth (weeks).
2.8
2.8. Analysis
Comparison 2 Energy‐restricted diet versus no energy‐restricted diet, Outcome 8 Macrosomia (> 4000 g).
2.9
2.9. Analysis
Comparison 2 Energy‐restricted diet versus no energy‐restricted diet, Outcome 9 Macrosomia (> 4500 g).
2.10
2.10. Analysis
Comparison 2 Energy‐restricted diet versus no energy‐restricted diet, Outcome 10 Birthweight (g).
2.11
2.11. Analysis
Comparison 2 Energy‐restricted diet versus no energy‐restricted diet, Outcome 11 Shoulder dystocia.
2.12
2.12. Analysis
Comparison 2 Energy‐restricted diet versus no energy‐restricted diet, Outcome 12 Bone fracture.
2.13
2.13. Analysis
Comparison 2 Energy‐restricted diet versus no energy‐restricted diet, Outcome 13 Nerve palsy.
2.14
2.14. Analysis
Comparison 2 Energy‐restricted diet versus no energy‐restricted diet, Outcome 14 Neonatal hypoglycaemia.
2.15
2.15. Analysis
Comparison 2 Energy‐restricted diet versus no energy‐restricted diet, Outcome 15 Neonatal hyperbilirubinemia.
2.16
2.16. Analysis
Comparison 2 Energy‐restricted diet versus no energy‐restricted diet, Outcome 16 Neonatal hypocalcaemia.
2.17
2.17. Analysis
Comparison 2 Energy‐restricted diet versus no energy‐restricted diet, Outcome 17 Normal vaginal birth.
2.18
2.18. Analysis
Comparison 2 Energy‐restricted diet versus no energy‐restricted diet, Outcome 18 Operative vaginal birth.
2.19
2.19. Analysis
Comparison 2 Energy‐restricted diet versus no energy‐restricted diet, Outcome 19 Induction of labour.
2.20
2.20. Analysis
Comparison 2 Energy‐restricted diet versus no energy‐restricted diet, Outcome 20 Gestational weight gain (kg).
2.21
2.21. Analysis
Comparison 2 Energy‐restricted diet versus no energy‐restricted diet, Outcome 21 Gestational weight gain: weight at birth (kg).
2.22
2.22. Analysis
Comparison 2 Energy‐restricted diet versus no energy‐restricted diet, Outcome 22 Insulin sensitivity: during intervention fasting plasma insulin (pM).
2.23
2.23. Analysis
Comparison 2 Energy‐restricted diet versus no energy‐restricted diet, Outcome 23 Insulin sensitivity: end of intervention fasting plasma insulin (pM).
2.24
2.24. Analysis
Comparison 2 Energy‐restricted diet versus no energy‐restricted diet, Outcome 24 Use of additional pharmacotherapy.
2.25
2.25. Analysis
Comparison 2 Energy‐restricted diet versus no energy‐restricted diet, Outcome 25 Glycaemic control: during intervention preprandial/fasting glucose (mmol/L).
2.26
2.26. Analysis
Comparison 2 Energy‐restricted diet versus no energy‐restricted diet, Outcome 26 Glycaemic control: during intervention 24 hour mean plasma glucose (mmol/L).
2.27
2.27. Analysis
Comparison 2 Energy‐restricted diet versus no energy‐restricted diet, Outcome 27 Glycaemic control: during intervention 1 hour postprandial glucose (mmol/L).
2.28
2.28. Analysis
Comparison 2 Energy‐restricted diet versus no energy‐restricted diet, Outcome 28 Glycaemic control: end of intervention preprandial/fasting glucose (mmol/L).
2.29
2.29. Analysis
Comparison 2 Energy‐restricted diet versus no energy‐restricted diet, Outcome 29 Glycaemic control: end of intervention 24‐hour mean plasma glucose (mmol/L).
2.30
2.30. Analysis
Comparison 2 Energy‐restricted diet versus no energy‐restricted diet, Outcome 30 Glycaemic control: end of intervention 1‐hour postprandial glucose (mmol/L).
2.31
2.31. Analysis
Comparison 2 Energy‐restricted diet versus no energy‐restricted diet, Outcome 31 Glycaemic control: during/at end of intervention fasting glucose (mmol/L).
2.32
2.32. Analysis
Comparison 2 Energy‐restricted diet versus no energy‐restricted diet, Outcome 32 Glycaemic control: during/at end of intervention mean plasma glucose (mmol/L).
2.33
2.33. Analysis
Comparison 2 Energy‐restricted diet versus no energy‐restricted diet, Outcome 33 Glycaemic control: during/at end of intervention mean HbA1c (%).
3.1
3.1. Analysis
Comparison 3 DASH diet versus control diet with matching macronutrient contents, Outcome 1 Hypertensive disorders of pregnancy: pre‐eclampsia.
3.2
3.2. Analysis
Comparison 3 DASH diet versus control diet with matching macronutrient contents, Outcome 2 Caesarean section.
3.3
3.3. Analysis
Comparison 3 DASH diet versus control diet with matching macronutrient contents, Outcome 3 Gestational age at birth (weeks).
3.4
3.4. Analysis
Comparison 3 DASH diet versus control diet with matching macronutrient contents, Outcome 4 Macrosomia (≥ 4000 g).
3.5
3.5. Analysis
Comparison 3 DASH diet versus control diet with matching macronutrient contents, Outcome 5 Birthweight (g).
3.6
3.6. Analysis
Comparison 3 DASH diet versus control diet with matching macronutrient contents, Outcome 6 Head circumference at birth (cm).
3.7
3.7. Analysis
Comparison 3 DASH diet versus control diet with matching macronutrient contents, Outcome 7 Length at birth(cm).
3.8
3.8. Analysis
Comparison 3 DASH diet versus control diet with matching macronutrient contents, Outcome 8 Ponderal index at birth (kg/m³).
3.9
3.9. Analysis
Comparison 3 DASH diet versus control diet with matching macronutrient contents, Outcome 9 Placental abruption.
3.10
3.10. Analysis
Comparison 3 DASH diet versus control diet with matching macronutrient contents, Outcome 10 Gestational weight gain: BMI at end of intervention (kg/m²).
3.11
3.11. Analysis
Comparison 3 DASH diet versus control diet with matching macronutrient contents, Outcome 11 Gestational weight gain: weight at end of intervention (kg).
3.12
3.12. Analysis
Comparison 3 DASH diet versus control diet with matching macronutrient contents, Outcome 12 Insulin sensitivity: end of intervention HOMA‐IR.
3.13
3.13. Analysis
Comparison 3 DASH diet versus control diet with matching macronutrient contents, Outcome 13 Insulin sensitivity: end of intervention insulin (µIU/mL).
3.14
3.14. Analysis
Comparison 3 DASH diet versus control diet with matching macronutrient contents, Outcome 14 Use of additional pharmacotherapy.
3.15
3.15. Analysis
Comparison 3 DASH diet versus control diet with matching macronutrient contents, Outcome 15 Glycaemic control: end of intervention fasting blood glucose (mmol/L).
3.16
3.16. Analysis
Comparison 3 DASH diet versus control diet with matching macronutrient contents, Outcome 16 Glycaemic control: at end of intervention HbA1c (%).
4.1
4.1. Analysis
Comparison 4 Low‐carbohydrate diet versus high‐carbohydrate diet, Outcome 1 Large‐for‐gestational age.
4.2
4.2. Analysis
Comparison 4 Low‐carbohydrate diet versus high‐carbohydrate diet, Outcome 2 Perinatal mortality (stillbirth and neonatal mortality).
4.3
4.3. Analysis
Comparison 4 Low‐carbohydrate diet versus high‐carbohydrate diet, Outcome 3 Hypertensive disorders of pregnancy: maternal hypertension.
4.4
4.4. Analysis
Comparison 4 Low‐carbohydrate diet versus high‐carbohydrate diet, Outcome 4 Caesarean section.
4.5
4.5. Analysis
Comparison 4 Low‐carbohydrate diet versus high‐carbohydrate diet, Outcome 5 Stillbirth.
4.6
4.6. Analysis
Comparison 4 Low‐carbohydrate diet versus high‐carbohydrate diet, Outcome 6 Gestational age at birth (weeks).
4.7
4.7. Analysis
Comparison 4 Low‐carbohydrate diet versus high‐carbohydrate diet, Outcome 7 Macrosomia (> 4000 g).
4.8
4.8. Analysis
Comparison 4 Low‐carbohydrate diet versus high‐carbohydrate diet, Outcome 8 Small‐for‐gestational age.
4.9
4.9. Analysis
Comparison 4 Low‐carbohydrate diet versus high‐carbohydrate diet, Outcome 9 Birthweight (g).
4.10
4.10. Analysis
Comparison 4 Low‐carbohydrate diet versus high‐carbohydrate diet, Outcome 10 Neonatal hypoglycaemia.
4.11
4.11. Analysis
Comparison 4 Low‐carbohydrate diet versus high‐carbohydrate diet, Outcome 11 Normal vaginal birth.
4.12
4.12. Analysis
Comparison 4 Low‐carbohydrate diet versus high‐carbohydrate diet, Outcome 12 Operative vaginal birth.
4.13
4.13. Analysis
Comparison 4 Low‐carbohydrate diet versus high‐carbohydrate diet, Outcome 13 Gestational weight gain: maternal weight gain (kg).
4.14
4.14. Analysis
Comparison 4 Low‐carbohydrate diet versus high‐carbohydrate diet, Outcome 14 Adherence to dietary intervention: fully applied the recommended menu.
4.15
4.15. Analysis
Comparison 4 Low‐carbohydrate diet versus high‐carbohydrate diet, Outcome 15 Use of additional pharmacotherapy..
4.16
4.16. Analysis
Comparison 4 Low‐carbohydrate diet versus high‐carbohydrate diet, Outcome 16 Glycaemic control: end of intervention fasting blood glucose (mg/dL).
4.17
4.17. Analysis
Comparison 4 Low‐carbohydrate diet versus high‐carbohydrate diet, Outcome 17 Glycaemic control: end of intervention 2‐hour post breakfast blood glucose (mg/dL).
4.18
4.18. Analysis
Comparison 4 Low‐carbohydrate diet versus high‐carbohydrate diet, Outcome 18 Glycaemic control: end of intervention 2‐hour post lunch blood glucose (mg/dL).
4.19
4.19. Analysis
Comparison 4 Low‐carbohydrate diet versus high‐carbohydrate diet, Outcome 19 Glycaemic control: end of intervention 2‐hour post dinner blood glucose (mg/dL).
5.1
5.1. Analysis
Comparison 5 High unsaturated fat diet versus low unsaturated fat diet with matching calories, Outcome 1 Large‐for‐gestational age.
5.2
5.2. Analysis
Comparison 5 High unsaturated fat diet versus low unsaturated fat diet with matching calories, Outcome 2 Hypertensive disorders of pregnancy: pre‐eclampsia.
5.3
5.3. Analysis
Comparison 5 High unsaturated fat diet versus low unsaturated fat diet with matching calories, Outcome 3 Hypertensive disorders of pregnancy: hypertension in pregnancy.
5.4
5.4. Analysis
Comparison 5 High unsaturated fat diet versus low unsaturated fat diet with matching calories, Outcome 4 Caesarean section.
5.5
5.5. Analysis
Comparison 5 High unsaturated fat diet versus low unsaturated fat diet with matching calories, Outcome 5 Type 2 diabetes: 'diabetic' OGTT 1‐2 weeks postpartum.
5.6
5.6. Analysis
Comparison 5 High unsaturated fat diet versus low unsaturated fat diet with matching calories, Outcome 6 Type 2 diabetes: 'diabetic' OGTT 4‐13 months postpartum.
5.7
5.7. Analysis
Comparison 5 High unsaturated fat diet versus low unsaturated fat diet with matching calories, Outcome 7 Gestational age at birth (weeks).
5.8
5.8. Analysis
Comparison 5 High unsaturated fat diet versus low unsaturated fat diet with matching calories, Outcome 8 Preterm birth.
5.9
5.9. Analysis
Comparison 5 High unsaturated fat diet versus low unsaturated fat diet with matching calories, Outcome 9 Macrosomia (> 4000 g).
5.10
5.10. Analysis
Comparison 5 High unsaturated fat diet versus low unsaturated fat diet with matching calories, Outcome 10 Birthweight (g).
5.11
5.11. Analysis
Comparison 5 High unsaturated fat diet versus low unsaturated fat diet with matching calories, Outcome 11 Placental abruption.
5.12
5.12. Analysis
Comparison 5 High unsaturated fat diet versus low unsaturated fat diet with matching calories, Outcome 12 Gestational weight gain (kg).
5.13
5.13. Analysis
Comparison 5 High unsaturated fat diet versus low unsaturated fat diet with matching calories, Outcome 13 Gestational weight gain: BMI at birth (kg/m²).
5.14
5.14. Analysis
Comparison 5 High unsaturated fat diet versus low unsaturated fat diet with matching calories, Outcome 14 Gestational weight gain: weight at birth (kg).
5.15
5.15. Analysis
Comparison 5 High unsaturated fat diet versus low unsaturated fat diet with matching calories, Outcome 15 Insulin sensitivity: during intervention (38 week) insulin (mU/L).
5.16
5.16. Analysis
Comparison 5 High unsaturated fat diet versus low unsaturated fat diet with matching calories, Outcome 16 Insulin sensitivity: during intervention (38 week) insulin sensitivity (10‐5 min‐1 per mU/L min).
5.17
5.17. Analysis
Comparison 5 High unsaturated fat diet versus low unsaturated fat diet with matching calories, Outcome 17 Insulin sensitivity: end of intervention IAI.
5.18
5.18. Analysis
Comparison 5 High unsaturated fat diet versus low unsaturated fat diet with matching calories, Outcome 18 Use of additional pharmacotherapy.
5.19
5.19. Analysis
Comparison 5 High unsaturated fat diet versus low unsaturated fat diet with matching calories, Outcome 19 Glycaemic control: during intervention (38 week) fasting blood glucose (mmol/L).
5.20
5.20. Analysis
Comparison 5 High unsaturated fat diet versus low unsaturated fat diet with matching calories, Outcome 20 Glycaemic control: during intervention (38 week) postprandial glucose (mmol/L).
5.21
5.21. Analysis
Comparison 5 High unsaturated fat diet versus low unsaturated fat diet with matching calories, Outcome 21 Glycaemic control: during intervention (38 week) HbA1c (%).
5.22
5.22. Analysis
Comparison 5 High unsaturated fat diet versus low unsaturated fat diet with matching calories, Outcome 22 Glycaemic control: end of intervention fasting blood glucose (mmol/L).
5.23
5.23. Analysis
Comparison 5 High unsaturated fat diet versus low unsaturated fat diet with matching calories, Outcome 23 Glycaemic control: end of intervention 2‐hour postprandial blood glucose (mmol/L).
5.24
5.24. Analysis
Comparison 5 High unsaturated fat diet versus low unsaturated fat diet with matching calories, Outcome 24 BMI 5‐9 months postpartum (kg/m²).
5.25
5.25. Analysis
Comparison 5 High unsaturated fat diet versus low unsaturated fat diet with matching calories, Outcome 25 Impaired glucose tolerance: 'borderline' OGTT 1‐2 weeks postpartum.
5.26
5.26. Analysis
Comparison 5 High unsaturated fat diet versus low unsaturated fat diet with matching calories, Outcome 26 Impaired glucose tolerance: 'borderline' OGTT 4‐13 months postpartum.
6.1
6.1. Analysis
Comparison 6 Low‐GI diet versus high‐fibre moderate‐GI diet, Outcome 1 Large‐for‐gestational age.
6.2
6.2. Analysis
Comparison 6 Low‐GI diet versus high‐fibre moderate‐GI diet, Outcome 2 Caesarean section.
6.3
6.3. Analysis
Comparison 6 Low‐GI diet versus high‐fibre moderate‐GI diet, Outcome 3 Type 2 diabetes mellitus at 3 months postpartum.
6.4
6.4. Analysis
Comparison 6 Low‐GI diet versus high‐fibre moderate‐GI diet, Outcome 4 Gestational age at birth (weeks).
6.5
6.5. Analysis
Comparison 6 Low‐GI diet versus high‐fibre moderate‐GI diet, Outcome 5 Preterm birth.
6.6
6.6. Analysis
Comparison 6 Low‐GI diet versus high‐fibre moderate‐GI diet, Outcome 6 Macrosomia (> 4000 g).
6.7
6.7. Analysis
Comparison 6 Low‐GI diet versus high‐fibre moderate‐GI diet, Outcome 7 Small‐for‐gestational age.
6.8
6.8. Analysis
Comparison 6 Low‐GI diet versus high‐fibre moderate‐GI diet, Outcome 8 Birthweight (g).
6.9
6.9. Analysis
Comparison 6 Low‐GI diet versus high‐fibre moderate‐GI diet, Outcome 9 Head circumference at birth (cm).
6.10
6.10. Analysis
Comparison 6 Low‐GI diet versus high‐fibre moderate‐GI diet, Outcome 10 Length at birth (cm).
6.11
6.11. Analysis
Comparison 6 Low‐GI diet versus high‐fibre moderate‐GI diet, Outcome 11 Ponderal index at birth (kg/m³).
6.13
6.13. Analysis
Comparison 6 Low‐GI diet versus high‐fibre moderate‐GI diet, Outcome 13 Weight gain during pregnancy (kg).
6.14
6.14. Analysis
Comparison 6 Low‐GI diet versus high‐fibre moderate‐GI diet, Outcome 14 Adherence to dietary intervention.
6.15
6.15. Analysis
Comparison 6 Low‐GI diet versus high‐fibre moderate‐GI diet, Outcome 15 Insulin sensitivity: end of intervention: HOMA2‐IR (%).
6.16
6.16. Analysis
Comparison 6 Low‐GI diet versus high‐fibre moderate‐GI diet, Outcome 16 Insulin sensitivity: end of intervention insulin (pmol/L).
6.17
6.17. Analysis
Comparison 6 Low‐GI diet versus high‐fibre moderate‐GI diet, Outcome 17 Use of additional pharmacotherapy.
6.18
6.18. Analysis
Comparison 6 Low‐GI diet versus high‐fibre moderate‐GI diet, Outcome 18 Glycaemic control: end of intervention blood glucose (mmol/L).
6.20
6.20. Analysis
Comparison 6 Low‐GI diet versus high‐fibre moderate‐GI diet, Outcome 20 Return to pre‐pregnancy weight at 3 months postpartum.
6.21
6.21. Analysis
Comparison 6 Low‐GI diet versus high‐fibre moderate‐GI diet, Outcome 21 BMI at 3 months postpartum (kg/m²).
6.22
6.22. Analysis
Comparison 6 Low‐GI diet versus high‐fibre moderate‐GI diet, Outcome 22 Impaired glucose tolerance at 3 months postpartum.
6.23
6.23. Analysis
Comparison 6 Low‐GI diet versus high‐fibre moderate‐GI diet, Outcome 23 Insulin sensitivity at 3 months postpartum (insulin (pmol/L)).
6.24
6.24. Analysis
Comparison 6 Low‐GI diet versus high‐fibre moderate‐GI diet, Outcome 24 Insulin sensitivity at 3 months postpartum (HOMA‐IR (%)).
7.1
7.1. Analysis
Comparison 7 Diet recommendation + diet‐related behavioural advice versus diet recommendation only, Outcome 1 Large‐for‐gestational age.
7.2
7.2. Analysis
Comparison 7 Diet recommendation + diet‐related behavioural advice versus diet recommendation only, Outcome 2 Caesarean section.
7.3
7.3. Analysis
Comparison 7 Diet recommendation + diet‐related behavioural advice versus diet recommendation only, Outcome 3 Preterm birth (< 37 weeks' gestation).
7.4
7.4. Analysis
Comparison 7 Diet recommendation + diet‐related behavioural advice versus diet recommendation only, Outcome 4 Gestational weight gain: BMI at end of intervention (kg/m²).
7.5
7.5. Analysis
Comparison 7 Diet recommendation + diet‐related behavioural advice versus diet recommendation only, Outcome 5 Gestational weight gain: weight at end of intervention (kg).
7.6
7.6. Analysis
Comparison 7 Diet recommendation + diet‐related behavioural advice versus diet recommendation only, Outcome 6 Insulin sensitivity: end of intervention HOMA‐IR.
7.7
7.7. Analysis
Comparison 7 Diet recommendation + diet‐related behavioural advice versus diet recommendation only, Outcome 7 Insulin sensitivity: end of intervention fasting insulin (µU/mL).
7.8
7.8. Analysis
Comparison 7 Diet recommendation + diet‐related behavioural advice versus diet recommendation only, Outcome 8 Use of additional pharmacotherapy.
7.9
7.9. Analysis
Comparison 7 Diet recommendation + diet‐related behavioural advice versus diet recommendation only, Outcome 9 Glycaemic control: end of intervention fasting glucose (mg/dL).
7.10
7.10. Analysis
Comparison 7 Diet recommendation + diet‐related behavioural advice versus diet recommendation only, Outcome 10 Glycaemic control: end of intervention postprandial glucose (mg/dL).
7.11
7.11. Analysis
Comparison 7 Diet recommendation + diet‐related behavioural advice versus diet recommendation only, Outcome 11 Glycaemic control: end of intervention HbA1c (%).
7.12
7.12. Analysis
Comparison 7 Diet recommendation + diet‐related behavioural advice versus diet recommendation only, Outcome 12 Length of postnatal stay (baby): stay > 4 days.
8.1
8.1. Analysis
Comparison 8 Soy protein‐enriched diet versus no soy protein diet, Outcome 1 Hypertensive disorders of pregnancy: pre‐eclampsia.
8.2
8.2. Analysis
Comparison 8 Soy protein‐enriched diet versus no soy protein diet, Outcome 2 Caesarean section.
8.3
8.3. Analysis
Comparison 8 Soy protein‐enriched diet versus no soy protein diet, Outcome 3 Gestational age at birth (weeks).
8.4
8.4. Analysis
Comparison 8 Soy protein‐enriched diet versus no soy protein diet, Outcome 4 Preterm birth (< 37 weeks' gestation).
8.5
8.5. Analysis
Comparison 8 Soy protein‐enriched diet versus no soy protein diet, Outcome 5 Macrosomia (> 4000 g).
8.6
8.6. Analysis
Comparison 8 Soy protein‐enriched diet versus no soy protein diet, Outcome 6 Birthweight (g).
8.7
8.7. Analysis
Comparison 8 Soy protein‐enriched diet versus no soy protein diet, Outcome 7 Head circumference at birth (cm).
8.8
8.8. Analysis
Comparison 8 Soy protein‐enriched diet versus no soy protein diet, Outcome 8 Length at birth (cm).
8.9
8.9. Analysis
Comparison 8 Soy protein‐enriched diet versus no soy protein diet, Outcome 9 Neonatal hypoglycaemia.
8.10
8.10. Analysis
Comparison 8 Soy protein‐enriched diet versus no soy protein diet, Outcome 10 Neonatal hyperbilirubinaemia.
8.11
8.11. Analysis
Comparison 8 Soy protein‐enriched diet versus no soy protein diet, Outcome 11 Gestational weight gain: BMI at end of intervention (kg/m²).
8.12
8.12. Analysis
Comparison 8 Soy protein‐enriched diet versus no soy protein diet, Outcome 12 Gestational weight gain: weight at end of intervention (kg).
8.13
8.13. Analysis
Comparison 8 Soy protein‐enriched diet versus no soy protein diet, Outcome 13 Insulin sensitivity: end of intervention HOMA‐IR.
8.14
8.14. Analysis
Comparison 8 Soy protein‐enriched diet versus no soy protein diet, Outcome 14 Insulin sensitivity: end of intervention QUICKI.
8.15
8.15. Analysis
Comparison 8 Soy protein‐enriched diet versus no soy protein diet, Outcome 15 Insulin sensitivity: end of intervention insulin (µIU/mL).
8.16
8.16. Analysis
Comparison 8 Soy protein‐enriched diet versus no soy protein diet, Outcome 16 Use of additional pharmacotherapy.
8.17
8.17. Analysis
Comparison 8 Soy protein‐enriched diet versus no soy protein diet, Outcome 17 Glycaemic control: end of intervention fasting plasma glucose (mg/dL).
8.18
8.18. Analysis
Comparison 8 Soy protein‐enriched diet versus no soy protein diet, Outcome 18 Number of antenatal visits or admissions: maternal hospitalisation.
8.19
8.19. Analysis
Comparison 8 Soy protein‐enriched diet versus no soy protein diet, Outcome 19 Neonatal intensive care unit admission: neonatal hospitalisations.
9.1
9.1. Analysis
Comparison 9 High‐fibre diet versus standard‐fibre diet, Outcome 1 Gestational age at birth (weeks).
9.2
9.2. Analysis
Comparison 9 High‐fibre diet versus standard‐fibre diet, Outcome 2 Birthweight (g).
9.3
9.3. Analysis
Comparison 9 High‐fibre diet versus standard‐fibre diet, Outcome 3 Gestational weight gain (kg).
9.4
9.4. Analysis
Comparison 9 High‐fibre diet versus standard‐fibre diet, Outcome 4 Use of additional pharmacotherapy.
9.5
9.5. Analysis
Comparison 9 High‐fibre diet versus standard‐fibre diet, Outcome 5 Glycaemic control during/at end of intervention: mean blood glucose (mg/dL).
9.6
9.6. Analysis
Comparison 9 High‐fibre diet versus standard‐fibre diet, Outcome 6 Maternal hypoglycaemia: mean number of events.
10.1
10.1. Analysis
Comparison 10 Ethnic‐specific diet versus standard healthy diet, Outcome 1 Large‐for‐gestational age.
10.2
10.2. Analysis
Comparison 10 Ethnic‐specific diet versus standard healthy diet, Outcome 2 Neonatal composite outcome: hypoglycaemia, neonatal asphyxia, respiratory distress syndrome, and hyperbilirubinaemia, hypocalcaemia.
10.3
10.3. Analysis
Comparison 10 Ethnic‐specific diet versus standard healthy diet, Outcome 3 Hypertensive disorders of pregnancy: gestational hypertension.
10.4
10.4. Analysis
Comparison 10 Ethnic‐specific diet versus standard healthy diet, Outcome 4 Caesarean section.
10.5
10.5. Analysis
Comparison 10 Ethnic‐specific diet versus standard healthy diet, Outcome 5 Gestational age at birth (weeks).
10.6
10.6. Analysis
Comparison 10 Ethnic‐specific diet versus standard healthy diet, Outcome 6 Macrosomia (> 4000 g).
10.7
10.7. Analysis
Comparison 10 Ethnic‐specific diet versus standard healthy diet, Outcome 7 Small‐for‐gestational age.
10.8
10.8. Analysis
Comparison 10 Ethnic‐specific diet versus standard healthy diet, Outcome 8 Birthweight (g).
10.9
10.9. Analysis
Comparison 10 Ethnic‐specific diet versus standard healthy diet, Outcome 9 Respiratory distress syndrome.
10.10
10.10. Analysis
Comparison 10 Ethnic‐specific diet versus standard healthy diet, Outcome 10 Neonatal hypoglycaemia.
10.11
10.11. Analysis
Comparison 10 Ethnic‐specific diet versus standard healthy diet, Outcome 11 Neonatal hyperbilirubinaemia.
10.12
10.12. Analysis
Comparison 10 Ethnic‐specific diet versus standard healthy diet, Outcome 12 Neonatal hypocalcaemia.
10.13
10.13. Analysis
Comparison 10 Ethnic‐specific diet versus standard healthy diet, Outcome 13 Gestational weight gain (kg).
10.14
10.14. Analysis
Comparison 10 Ethnic‐specific diet versus standard healthy diet, Outcome 14 Adherence to dietary intervention: good adherence.
10.15
10.15. Analysis
Comparison 10 Ethnic‐specific diet versus standard healthy diet, Outcome 15 Use of additional pharmacotherapy.

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References

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