Kleine-Levin Syndrome
- PMID: 28216256
- DOI: 10.1016/j.prrv.2016.12.004
Kleine-Levin Syndrome
Abstract
Kleine-Levin syndrome (KLS) is a rare disorder characterized by discrete episodes of hypersomnia associated with cognitive and behavioural abnormalities, as well as normal alertness and function between episodes. The prevalence of KLS may be underestimated as it is often misdiagnosed and managed as another sleep disorder, neurological disorder or psychiatric condition. KLS is more typically seen in adolescence than at other ages, and is more common in males than in females. There are currently neither standard biomarkers nor specific imaging study findings, making the diagnosis of KLS a challenge. Furthermore, there are no consistently effective therapies. The prognosis, however, is felt to be overall favorable, as episodes become progressively milder and less frequent before resolving entirely in most patients.
Keywords: Hyperphagia; Hypersexuality; Hypersomnia; Kleine-Levin Syndrome.
Copyright © 2016. Published by Elsevier Ltd.
Similar articles
-
Kleine-Levin syndrome: the first typical case in Thailand.J Med Assoc Thai. 2010 Nov;93 Suppl 6:S218-22. J Med Assoc Thai. 2010. PMID: 21280539
-
Kleine-Levin syndrome and bipolar disorder: a differential diagnosis of recurrent and resistant depression.Bipolar Disord. 2013 Dec;15(8):899-902. doi: 10.1111/bdi.12119. Epub 2013 Sep 6. Bipolar Disord. 2013. PMID: 24034447
-
[Kleine Levin Syndrome: more than just periodic hypersomnia].Ned Tijdschr Geneeskd. 2016;160:D238. Ned Tijdschr Geneeskd. 2016. PMID: 27484420 Dutch.
-
[Kleine-Levin syndrome: state of the art].Rev Neurol (Paris). 2008 Aug-Sep;164(8-9):658-68. doi: 10.1016/j.neurol.2008.04.020. Epub 2008 Jul 23. Rev Neurol (Paris). 2008. PMID: 18653203 Review. French.
-
Pharmacological treatment for Kleine-Levin syndrome.Cochrane Database Syst Rev. 2016 May 6;2016(5):CD006685. doi: 10.1002/14651858.CD006685.pub4. Cochrane Database Syst Rev. 2016. PMID: 27153153 Free PMC article. Review.
Cited by
-
Relapse of Kleine-Levin Syndrome From COVID-19 Vaccine: Causal or Coincidence?J Clin Neurol. 2023 Sep;19(5):512-513. doi: 10.3988/jcn.2023.0132. J Clin Neurol. 2023. PMID: 37635431 Free PMC article. No abstract available.
-
Increase in the Number and Duration of Sleep Episodes During Class After Reopening of Schools Following Closure due to COVID-19.Kobe J Med Sci. 2022 Dec 21;68(1):E23-E29. Kobe J Med Sci. 2022. PMID: 36647083 Free PMC article.
-
Neuroimaging in the Rare Sleep Disorder of Kleine-Levin Syndrome: A Systematic Review.Clocks Sleep. 2022 May 31;4(2):287-299. doi: 10.3390/clockssleep4020025. Clocks Sleep. 2022. PMID: 35735605 Free PMC article. Review.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical