Integrating Hebbian and homeostatic plasticity: the current state of the field and future research directions

Tara Keck¹, Taro Toyoizumi², Lu Chen³, Brent Doiron⁴, Daniel E Feldman⁵, Kevin Fox⁶, Wulfram Gerstner⁷, Philip G Haydon⁸, Mark Hübener⁹, Hey-Kyoung Lee¹⁰, John E Lisman¹¹, Tobias Rose⁹, Frank Sengpiel^{12

6}, David Stellwagen¹³, Michael P Stryker¹⁴, Gina G Turrigiano¹¹, Mark C van Rossum¹⁵

Affiliations

¹ Department of Neuroscience, Physiology and Pharmacology, University College London, London, UK t.keck@ucl.ac.uk.
² RIKEN Brain Science Institute, Wako, Japan.
³ Department of Neurosurgery, Stanford University, Stanford, CA, USA.
⁴ Department of Mathematics, University of Pittsburgh, Pittsburgh, PA, USA.
⁵ Department of Molecular and Cell Biology, University of California, Berkeley, CA, USA.
⁶ Division of Neuroscience, University of Cardiff, Cardiff, Wales, UK.
⁷ Brain Mind Institute, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.
⁸ Tufts University School of Medicine, Medford, MA, USA.
⁹ Department of Cellular and Systems Neuroscience, Max Planck Institute of Neurobiology, Martinsried, Bayern, Germany.
¹⁰ The Zanvyl Krieger Mind/Brain Institute, Johns Hopkins University, Baltimore, MD, USA.
¹¹ Department of Biology, Brandeis University, Waltham, MA, USA.
¹² Department of Neuroscience, Physiology and Pharmacology, University College London, London, UK.
¹³ Centre for Research in Neuroscience, McGill University, Montreal, Quebec, Canada.
¹⁴ Sandler Neurosciences Center, University of California, San Francisco, CA, USA.
¹⁵ School of Informatics, University of Edinburgh, Edinburgh, UK.

PMID: 28093552
PMCID: PMC5247590
DOI: 10.1098/rstb.2016.0158

Integrating Hebbian and homeostatic plasticity: the current state of the field and future research directions

Tara Keck et al. Philos Trans R Soc Lond B Biol Sci. 2017.

. 2017 Mar 5;372(1715):20160158.

doi: 10.1098/rstb.2016.0158.

Authors

Affiliations

¹ Department of Neuroscience, Physiology and Pharmacology, University College London, London, UK t.keck@ucl.ac.uk.
² RIKEN Brain Science Institute, Wako, Japan.
³ Department of Neurosurgery, Stanford University, Stanford, CA, USA.
⁴ Department of Mathematics, University of Pittsburgh, Pittsburgh, PA, USA.
⁵ Department of Molecular and Cell Biology, University of California, Berkeley, CA, USA.
⁶ Division of Neuroscience, University of Cardiff, Cardiff, Wales, UK.
⁷ Brain Mind Institute, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.
⁸ Tufts University School of Medicine, Medford, MA, USA.
⁹ Department of Cellular and Systems Neuroscience, Max Planck Institute of Neurobiology, Martinsried, Bayern, Germany.
¹⁰ The Zanvyl Krieger Mind/Brain Institute, Johns Hopkins University, Baltimore, MD, USA.
¹¹ Department of Biology, Brandeis University, Waltham, MA, USA.
¹² Department of Neuroscience, Physiology and Pharmacology, University College London, London, UK.
¹³ Centre for Research in Neuroscience, McGill University, Montreal, Quebec, Canada.
¹⁴ Sandler Neurosciences Center, University of California, San Francisco, CA, USA.
¹⁵ School of Informatics, University of Edinburgh, Edinburgh, UK.

PMID: 28093552
PMCID: PMC5247590
DOI: 10.1098/rstb.2016.0158

Abstract

We summarize here the results presented and subsequent discussion from the meeting on Integrating Hebbian and Homeostatic Plasticity at the Royal Society in April 2016. We first outline the major themes and results presented at the meeting. We next provide a synopsis of the outstanding questions that emerged from the discussion at the end of the meeting and finally suggest potential directions of research that we believe are most promising to develop an understanding of how these two forms of plasticity interact to facilitate functional changes in the brain.This article is part of the themed issue 'Integrating Hebbian and homeostatic plasticity'.

Keywords: Hebbian plasticity; homeostatic mechanisms; theoretical modelling.

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Integrating Hebbian and homeostatic plasticity: the current state of the field and future research directions

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Integrating Hebbian and homeostatic plasticity: the current state of the field and future research directions

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