Review
doi: 10.1213/ANE.0000000000001580.
The Hypothalamic-Pituitary-Adrenal Axis and Anesthetics: A Review
Affiliations
- PMID: 27984246
- DOI: 10.1213/ANE.0000000000001580
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Review
The Hypothalamic-Pituitary-Adrenal Axis and Anesthetics: A Review
Anesth Analg.
2017 Apr.
Abstract
The hypothalamic-pituitary-adrenal (HPA) axis is essential for human adaptation to stress. However, many anesthetic agents may interfere with the activity of this axis. Although etomidate is known for its suppressive effect on HPA axis function, in vitro evidence suggests that many other drugs used in anesthesia care may also interfere with HPA activity. In this review, we discuss the mechanisms by which all HPA axis activity may be altered during anesthesia and critical care and focus on the impact of hypnotic and analgesic drugs.
Comment in
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Is Etomidate Sedation Associated With Excess Mortality in Intensive Care Unit Patients? What Is the Evidence?Anesth Analg. 2017 Aug;125(2):713. doi: 10.1213/ANE.0000000000002266. Anesth Analg. 2017. PMID: 28661920 No abstract available.
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