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. 2017 Nov;39(1):1-6.
doi: 10.1080/0886022X.2016.1244070. Epub 2016 Nov 15.

Protective effect of Silybum marianum and Taraxacum officinale extracts against oxidative kidney injuries induced by carbon tetrachloride in rats

Ali Karakuş  1 , Yeter Değer  2 , Serkan Yıldırım  3
Affiliations

Protective effect of Silybum marianum and Taraxacum officinale extracts against oxidative kidney injuries induced by carbon tetrachloride in rats

Ali Karakuş et al. Ren Fail. 2017 Nov.

Abstract

The protective effect of the extracts of the plants Silybum marianum and Taraxacum officinale by carbon tetrachloride (CCl4) was researched. Sixty-six female Wistar albino rats were divided into six groups: Control, Silybum marianum, Taraxacum officinale, CCl4, Silybum marianum+ CCl4, Taraxacum officinale+CCl4. The Silybum marianum and Taraxacum officinale extracts were administered as 100 mg/kg/day by gavage. The CCl4 was administered as 1.5 mL/kg (i.p.). At the end of the trial period, in the serums obtained from the animals, in the CCl4 group it was found that the MDA level increased in the kidney tissue samples as well as in the ALP and GGT enzyme activities. It was also found that the GSH level and the GST enzyme activities decreased (p<.05). The microscopic evaluations showed that the CCl4 caused a serious hydropic degeneration, coagulation necrosis, and mono-nuclear cell infiltration in the kidney cell. In the animals where CCl4 and Silybum marianum and Taraxacum officinale extracts were applied together, it was found that the serum ALP and GGT enzyme activities decreased and that the MDA level decreased in the kidney tissue, and that the GSH level and GST enzyme activities increased. It was observed that the histopathological changes caused by the CCl4 toxicity were corrected by applying the extracts. Eventually, it was determined that the Silybum marianum was more effective. Silybum marianum and Taraxacum officinale extracts which were used against histopathological changes in the kidney caused by toxication showed a corrective effect, which were supported by biochemical parameters.

Keywords: Carbon tetrachloride; Silybum marianum; Taraxacum officinale; kidney; oxidative stress.

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Figures

Figure 1.
Figure 1.
The normal histopathological structure of kidney tissue of the control (K) group (A). Atrophy in the glomerulus, dilation in Bowman's capsule and tubulus, severe hydropic degeneration of tubular epithelium, coagulation necrosis, tubule epithelium scattered on tubular lumen histopathological structure of kidney tissue of the CCl4 (C) group (B). Histopathological structure of kidney tissue of Silybum marianum (SM) group (C). Histopathological structure of kidney tissue of Taraxacum officinale (TO) group (D). Silybum marianum+ CCl4 (SM + C) group: kidneys, hyperemia, and degeneration in very few numbers of tubular epithelium (E). Taraxacum officinale+ CCl4 (TO + C) group: mild hydropic degeneration of tubular epithelium, very few numbers of necrotic cells (F) HxE, Bar: 20 μm.
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