The effect of intravenous magnesium sulfate infusion on reduction of pain after abdominal hysterectomy under general anesthesia: a double-blind, randomized clinical trial
- PMID: 27648185
- PMCID: PMC5014497
- DOI: 10.19082/2602
The effect of intravenous magnesium sulfate infusion on reduction of pain after abdominal hysterectomy under general anesthesia: a double-blind, randomized clinical trial
Abstract
Background: Post-surgical pain is a physiological response to tissue trauma that produces unpleasant physiological effects with manifestations on various organic systems.
Objective: According to the effect of magnesium sulfate on the N-methyl-d-aspartate (NMDA) receptor, this study examined the effect of magnesium sulfate on the reduction of pain and the mean amount of narcotics consumed by patients after abdominal hysterectomies.
Methods: This double-blind clinical trial study was performed on 60 patients who had undergone abdominal hysterectomies in Shahid Sadoughi Hospital in Yazd, Iran, from 2013 to 2015. The patients were divided randomly into two groups of 30 members each. All of the patients received 2 mg of Midazolam and 2 mcg/kg of Fentanyl as the induction of anesthesia with propofol (2-2.5 mg/kg) and Atracurium 0.5 mg/kg was conducted. All of the patients received 5 mg of intravenous morphine 30 min after induction of anesthesia. Afterwards, the study group received 50 mg/kg of magnesium sulfate in 500 cm(3) of Ringer's serum during the 20 minutes, and 500 cm(3) of Ringer's serum was administered to the members of the placebo group. Visual analogue scale VAS scores were evaluated to reach the minimum difference of 0.8 in mean pain score.
Results: The results of this study indicated that the mean pain scores immediately after surgery and at 1, 2, 6, and 12 hr after surgery were lower in the study group than in the placebo group. The mean value of narcotic consumption at all measured time points was higher in the placebo group. No significant differences were found between two groups concerning drug complications.
Conclusion: The results of this study indicated that the intravenous injection of magnesium sulfate can reduce pain, reduce morphine consumption, and reduce the side effects of morphine in patients after surgery.
Funding: This study was funded by Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Clinical trial registration: The trial was registered at the Thai Clinical Trials Registry (http://www.clinicaltrials.in.th) with the registration ID: TCTR20160308001.
Keywords: Analgesic; Anesthesia; Hysterectomy; Magnesium sulfate; Pain.
Similar articles
-
Utilization of Magnesium for the Treatment of Chronic Pain.Anesth Pain Med. 2021 Feb 6;11(1):e112348. doi: 10.5812/aapm.112348. eCollection 2021 Feb. Anesth Pain Med. 2021. PMID: 34221945 Free PMC article. Review.
-
Intravenous magnesium sulfate vs. morphine sulfate in relieving renal colic: A randomized clinical trial.Am J Emerg Med. 2021 Aug;46:188-192. doi: 10.1016/j.ajem.2020.07.035. Epub 2020 Jul 21. Am J Emerg Med. 2021. PMID: 33071088 Clinical Trial.
-
Efficacy of Magnesium Sulfate Added to Local Anesthetic in a Transversus Abdominis Plane Block for Analgesia Following Total Abdominal Hysterectomy: A Randomized Trial.Pain Physician. 2017 Nov;20(7):641-647. Pain Physician. 2017. PMID: 29149143 Clinical Trial.
-
Effects of three different dose regimens of magnesium on propofol requirements, haemodynamic variables and postoperative pain relief in gynaecological surgery.Br J Anaesth. 2006 Feb;96(2):247-52. doi: 10.1093/bja/aei291. Epub 2005 Nov 25. Br J Anaesth. 2006. PMID: 16311277 Clinical Trial.
-
[Use of magnesium sulfate in anesthesiology].Medicina (Kaunas). 2002;38(7):695-8. Medicina (Kaunas). 2002. PMID: 12474653 Review. Lithuanian.
Cited by
-
Utilization of Magnesium for the Treatment of Chronic Pain.Anesth Pain Med. 2021 Feb 6;11(1):e112348. doi: 10.5812/aapm.112348. eCollection 2021 Feb. Anesth Pain Med. 2021. PMID: 34221945 Free PMC article. Review.
-
Effect of Magnesium Sulfate Added to Tincture of Opium and Buprenorphine on Pain and Quality of Life in Women with Dysmenorrhea: A Prospective, Randomized, Double-blind, Placebo-controlled Trial.Addict Health. 2020 Oct;12(4):259-268. doi: 10.22122/ahj.v12i4.285. Addict Health. 2020. PMID: 33623645 Free PMC article.
-
Pregabalin does not decrease acute pain or postoperative nausea and vomiting after hysterectomy: a meta-analysis.J Int Med Res. 2020 Dec;48(12):300060520954720. doi: 10.1177/0300060520954720. J Int Med Res. 2020. PMID: 33334230 Free PMC article.
-
Magnesium and Pain.Nutrients. 2020 Jul 23;12(8):2184. doi: 10.3390/nu12082184. Nutrients. 2020. PMID: 32718032 Free PMC article. Review.
-
Pregabalin can decrease acute pain and postoperative nausea and vomiting in hysterectomy: A meta-analysis.Medicine (Baltimore). 2017 Aug;96(31):e7714. doi: 10.1097/MD.0000000000007714. Medicine (Baltimore). 2017. PMID: 28767611 Free PMC article. Review.
References
-
- Miller RD, Pardo M. Basics of Anesthesia. Sixth edition. 2011.
-
- Wu CL, Fleisher LA. Outcomes research in regional anesthesia and analgesia. Anesth Analg. 2000;91(5):1232–42. - PubMed
-
- Liu S, Carpenter RL, Neal JM. Epidural anesthesia and analgesia, Their role in postoperative outcome. Anesthesiology. 1995;82(6):1474–506. - PubMed
-
- Stein C. The control of pain in peripheral tissue by opioids. N Engl J Med. 1995;332(25):1685–90. - PubMed
-
- Kissin I, Brown PT, Robinson CA, Bradley EL., Jr Acute tolerance in morphine analgesia: continuous infusion and single injection in rats. Anesthesiology. 1991;74(1):166–71. - PubMed
LinkOut - more resources
Full Text Sources
Other Literature Sources