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Case Reports
. 2016 Jul 14;2(3):264-8.
doi: 10.1016/j.jdcr.2016.05.002. eCollection 2016 May.

Immune-related sarcoidosis observed in combination ipilimumab and nivolumab therapy

Kathleen C Suozzi  1 , Maximilian Stahl  2 , Christine J Ko  1 , Anne Chiang  3 , Scott N Gettinger  3 , Mark D Siegel  2 , Christopher G Bunick  1
Affiliations
Case Reports

Immune-related sarcoidosis observed in combination ipilimumab and nivolumab therapy

Kathleen C Suozzi et al. JAAD Case Rep. .
No abstract available

Keywords: CTLA-4, cytotoxic T-lymphocyte–associated antigen 4; PD-1, programmed death–1; immune-related adverse events; immunotherapy; irAEs, immune-related adverse events; lung cancer; sarcoidosis.

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Figures

Fig 1
Fig 1
The spectrum of immune-related adverse events reported with checkpoint inhibitor therapy. The irAEs are graded based on severity from grade 1 to 4. Grade 2 to 3 reactions are typically managed by temporarily withholding medication with or without systemic corticosteroids. Grade 4 or grade 3 reaction that recurs is indication for discontinuing medication. Cutaneous irAEs can be managed with topical steroids if mild but may require systemic corticosteroids with long tapers to prevent recurrence. (*) indicates irAE reported in the literature in single case report. CN, Cranial nerve; GI, gastrointestinal.
Fig 2
Fig 2
Sarcoidosis in the setting of immune-related therapy for lung cancer. A, Distributed on the posterior neck and upper arms are greater than fifty 1- to 3-mm skin-colored to pink firm papules, in some areas coalescing into annular plaques. B, Dermal inflammatory infiltrate including relatively scant lymphocytes and epithelioid histiocytes arranged in well-defined granulomas. Giant cells are seen. There are no prominent epidermal changes. (Hematoxylin-eosin stain.)
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