Vitamin D and bronchopulmonary dysplasia in preterm infants
- PMID: 27467562
- PMCID: PMC5045784
- DOI: 10.1038/jp.2016.115
Vitamin D and bronchopulmonary dysplasia in preterm infants
Abstract
Objective: Vitamin D deficiency is associated with asthma and reactive airway disease in childhood but its potential contribution to bronchopulmonary dysplasia (BPD) in preterm infants is unknown. Preterm infants have lower levels of 25-hydroxyvitamin D (25(OH)D) at birth and are at risk for nutritional deficiencies after birth. The objective of the study was to evaluate the association of 25(OH)D concentrations at birth and at 36 weeks' corrected gestational age with BPD in preterm infants born before 29 completed weeks of gestation.
Study design: We collected umbilical cord blood samples from 44 preterm infants (gestational age <29 weeks) delivered at Brigham and Women's Hospital in Boston. In addition, with parental consent we collected venous samples at 36 weeks' corrected age from 20 preterm infants born before 29 weeks' gestation (including 6 infants with previously collected cord blood). Samples were frozen at -80 °C until subsequent measurement of 25(OH)D levels by chemiluminescence. We used multivariable logistic models to adjust for gestational age and considered other confounding variables, including maternal race, age, mode of delivery and infant sex.
Results: Among 44 infants, 41 (93.2%) survived and 3 (6.8%) died before 36 weeks' corrected age. Median 25(OH)D levels at birth were 30.4 ng ml(-1) in preterm infants who subsequently died or developed BPD and 33.8 ng ml(-1) in infants who survived without BPD (P=0.6). Median 25(OH)D levels at corrected age of 36 weeks were 59.0 ng ml(-1) among survivors without BPD and 64.2 ng ml(-1) among survivors with BPD (P=0.9). Neither cord blood nor 36 weeks' corrected 25(OH)D levels were associated with odds of death or BPD (adjusted odds ratio (OR) 1.00, 95% confidence interval (CI): 0.73 to 1.37; and OR 0.93, 95% CI: 0.61 to 1.43, respectively).
Conclusions: Among this population of extremely preterm infants neither cord blood nor the 36 weeks' corrected age 25(OH)D levels were associated with development of BPD. Notably, at the current level of supplementation, all extremely preterm infants in our cohort had achieved 25(OH)D levels >30 ng ml(-1) by 36 weeks' corrected age, which is thought to represent sufficiency in adult and pediatric populations.
Conflict of interest statement
Conflicts of Interest: None declared.
Similar articles
-
[Association between serum 25(OH)D levels at birth and bronchopulmonary dysplasia in preterm infants].Zhongguo Dang Dai Er Ke Za Zhi. 2017 Oct;19(10):1051-1055. doi: 10.7499/j.issn.1008-8830.2017.10.004. Zhongguo Dang Dai Er Ke Za Zhi. 2017. PMID: 29046199 Free PMC article. Chinese.
-
Maternal/neonatal vitamin D deficiency: a risk factor for bronchopulmonary dysplasia in preterms?J Perinatol. 2015 Oct;35(10):813-7. doi: 10.1038/jp.2015.88. Epub 2015 Jul 30. J Perinatol. 2015. PMID: 26226242
-
Is 25OH Vitamin D Excess before 36 Weeks Corrected Age an Independent Risk Factor for Bronchopulmonary Dysplasia or Death?Nutrients. 2023 Oct 18;15(20):4423. doi: 10.3390/nu15204423. Nutrients. 2023. PMID: 37892498 Free PMC article.
-
Inhalation or instillation of steroids for the prevention of bronchopulmonary dysplasia.Neonatology. 2015;107(4):358-9. doi: 10.1159/000381132. Epub 2015 Jun 5. Neonatology. 2015. PMID: 26044104 Review.
-
Maternal preeclampsia and risk of bronchopulmonary dysplasia in preterm infants.Pediatr Res. 2012 Feb;71(2):210-4. doi: 10.1038/pr.2011.27. Epub 2011 Dec 21. Pediatr Res. 2012. PMID: 22258134 Review.
Cited by
-
Prenatal vitamin D supplementation mitigates inflammation-related alveolar remodeling in neonatal mice.Am J Physiol Lung Cell Mol Physiol. 2023 Aug 1;325(2):L95-L103. doi: 10.1152/ajplung.00367.2022. Epub 2023 May 31. Am J Physiol Lung Cell Mol Physiol. 2023. PMID: 37256661 Free PMC article.
-
The association of serum vitamin D level and neonatal respiratory distress syndrome.Ital J Pediatr. 2023 Jan 30;49(1):16. doi: 10.1186/s13052-023-01415-w. Ital J Pediatr. 2023. PMID: 36717918 Free PMC article.
-
Vitamin d deficiency with high parathyroid hormone levels is related to late onset SEPSIS among preterm infants.BMC Pregnancy Childbirth. 2023 Jan 13;23(1):23. doi: 10.1186/s12884-022-05334-2. BMC Pregnancy Childbirth. 2023. PMID: 36639750 Free PMC article.
-
[Expert consensus on the follow-up management of bronchopulmonary dysplasia in preterm infants after discharge].Zhongguo Dang Dai Er Ke Za Zhi. 2022 May 15;24(5):455-465. doi: 10.7499/j.issn.1008-8830.2201078. Zhongguo Dang Dai Er Ke Za Zhi. 2022. PMID: 35644184 Free PMC article. Chinese.
-
Association between vitamin D deficiency at one month of age and bronchopulmonary dysplasia.Medicine (Baltimore). 2021 Dec 3;100(48):e27966. doi: 10.1097/MD.0000000000027966. Medicine (Baltimore). 2021. PMID: 35049200 Free PMC article.
References
-
- Jain D, Bancalari E. Bronchopulmonary dysplasia: clinical perspective. Birth Defects Res A Clin Mol Teratol 2014; 100(3): 134–144. - PubMed
-
- Woythaler MA, McCormick MC, Smith VC. Late preterm infants have worse 24-month neurodevelopmental outcomes than term infants. Pediatrics 2011; 127(3): e622–e629. - PubMed
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical