[Deficiency of folates in pregnancy: effect of supplementary folic acid]
- PMID: 2711281
[Deficiency of folates in pregnancy: effect of supplementary folic acid]
Abstract
Higher folate needs are present during pregnancy, which may lead to tissular deficiency in the mother and to depleted newborn folate reserves. The aim of this work was to assess the prevalence of folate deficiency and to establish the rates of serum and red cell folate in two groups of mothers and newborn infants, one receiving only iron and the other iron and folate during pregnancy. The rates of serum and red cell folate found at the end of pregnancy were significantly higher in the group which received folate; however, the percentage of cases with tissular folate deficiency was low in both groups, with no significant difference (3.8% and 1.3%, respectively). These findings, along with the lack of effect of supplemental folate on erythropoiesis, pose some questions on the usefulness of supplemental folate during pregnancy in our country.
Similar articles
-
Red cell folate and plasma homocysteine in preterm infants.Neonatology. 2007;92(4):264-8. doi: 10.1159/000103745. Epub 2007 Jun 8. Neonatology. 2007. PMID: 17556845
-
The serum and red cell folate levels in pregnant women in Beijing.Chin Med J (Engl). 1986 Nov;99(11):899-902. Chin Med J (Engl). 1986. PMID: 3107928 No abstract available.
-
[Serum and red cell folate levels in pregnant women].Zhonghua Yi Xue Za Zhi. 1986 Jul;66(7):417-9. Zhonghua Yi Xue Za Zhi. 1986. PMID: 3094913 Chinese. No abstract available.
-
[The importance of folic acid substitution in pregnancy].Geburtshilfe Frauenheilkd. 1989 Jun;49(6):523-8. doi: 10.1055/s-2008-1026610. Geburtshilfe Frauenheilkd. 1989. PMID: 2663617 Review. German.
-
Interaction of iron and folate during reproduction.Prog Food Nutr Sci. 1991;15(4):231-54. Prog Food Nutr Sci. 1991. PMID: 1784737 Review.
Cited by
-
Vitamin supplementation for preventing miscarriage.Cochrane Database Syst Rev. 2016 May 6;2016(5):CD004073. doi: 10.1002/14651858.CD004073.pub4. Cochrane Database Syst Rev. 2016. PMID: 27150280 Free PMC article. Review.
-
Daily oral iron supplementation during pregnancy.Cochrane Database Syst Rev. 2015 Jul 22;2015(7):CD004736. doi: 10.1002/14651858.CD004736.pub5. Cochrane Database Syst Rev. 2015. PMID: 26198451 Free PMC article. Review.
-
Folic acid supplementation during pregnancy for maternal health and pregnancy outcomes.Cochrane Database Syst Rev. 2013 Mar 28;2013(3):CD006896. doi: 10.1002/14651858.CD006896.pub2. Cochrane Database Syst Rev. 2013. PMID: 23543547 Free PMC article. Review.
-
Daily oral iron supplementation during pregnancy.Cochrane Database Syst Rev. 2012 Dec 12;12:CD004736. doi: 10.1002/14651858.CD004736.pub4. Cochrane Database Syst Rev. 2012. Update in: Cochrane Database Syst Rev. 2015 Jul 22;(7):CD004736. doi: 10.1002/14651858.CD004736.pub5. PMID: 23235616 Free PMC article. Updated. Review.
-
Folate intake and markers of folate status in women of reproductive age, pregnant and lactating women: a meta-analysis.J Nutr Metab. 2012;2012:470656. doi: 10.1155/2012/470656. Epub 2012 Sep 13. J Nutr Metab. 2012. PMID: 23024859 Free PMC article.