Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2016 Mar 15;6(2):603-21.
doi: 10.1002/cphy.c150015.

Regulation of the Hypothalamic-Pituitary-Adrenocortical Stress Response

James P Herman  1 , Jessica M McKlveen  1 , Sriparna Ghosal  1 , Brittany Kopp  1 , Aynara Wulsin  1 , Ryan Makinson  1 , Jessie Scheimann  1 , Brent Myers  1
Affiliations
Review

Regulation of the Hypothalamic-Pituitary-Adrenocortical Stress Response

James P Herman et al. Compr Physiol. .

Abstract

The hypothalamo-pituitary-adrenocortical (HPA) axis is required for stress adaptation. Activation of the HPA axis causes secretion of glucocorticoids, which act on multiple organ systems to redirect energy resources to meet real or anticipated demand. The HPA stress response is driven primarily by neural mechanisms, invoking corticotrophin releasing hormone (CRH) release from hypothalamic paraventricular nucleus (PVN) neurons. Pathways activating CRH release are stressor dependent: reactive responses to homeostatic disruption frequently involve direct noradrenergic or peptidergic drive of PVN neurons by sensory relays, whereas anticipatory responses use oligosynaptic pathways originating in upstream limbic structures. Anticipatory responses are driven largely by disinhibition, mediated by trans-synaptic silencing of tonic PVN inhibition via GABAergic neurons in the amygdala. Stress responses are inhibited by negative feedback mechanisms, whereby glucocorticoids act to diminish drive (brainstem) and promote transsynaptic inhibition by limbic structures (e.g., hippocampus). Glucocorticoids also act at the PVN to rapidly inhibit CRH neuronal activity via membrane glucocorticoid receptors. Chronic stress-induced activation of the HPA axis takes many forms (chronic basal hypersecretion, sensitized stress responses, and even adrenal exhaustion), with manifestation dependent upon factors such as stressor chronicity, intensity, frequency, and modality. Neural mechanisms driving chronic stress responses can be distinct from those controlling acute reactions, including recruitment of novel limbic, hypothalamic, and brainstem circuits. Importantly, an individual's response to acute or chronic stress is determined by numerous factors, including genetics, early life experience, environmental conditions, sex, and age. The context in which stressors occur will determine whether an individual's acute or chronic stress responses are adaptive or maladaptive (pathological).

PubMed Disclaimer

Figures

Figure 1
Figure 1
Organization of the hypothalamo-pituitary-adrenocortical (HPA) axis. HPA axis stress responses are initiated by corticotropin releasing hormone (CRH) neurons in the paraventricular nucleus of the hypothalamus (PVN). Stressors cause release of CRH into the hypophysial portal vessels, which transport peptide to the anterior pituitary to enable access to corticotrophs. Stimulated corticotrophs then release adrenocorticotrophic hormone (ACTH) into the systemic circulation, whereby it promotes synthesis and secretion of glucocorticoids (cortisol in some species (e.g., man), corticosterone in others (e.g., rats, mice)) at the adrenal cortex. Glucocorticoids are then secreted into the systemic circulation and can access cognate receptors in virtually every organ system, including the brain. Reproduced from (117), with permission.
Figure 2
Figure 2
Temporal dynamics of HPA axis stress responses. In response to stress, ACTH is released within minutes of stimulation. The extent of ACTH release is limited by rapid, non-genomic fast feedback mechanisms (usually peaking within 15 min of stressor onset)(see text). Due to the time needed for ACTH to access the adrenal cortex and promote glucocorticoid synthesis and release, there is a substantial delay between time-to-peak for corticosterone relative to ACTH (usually within 30–60 minutes). In addition to shutdown by fast feedback inhibition of ACTH release, the time course of the corticosterone response (usually on the order of 2 hours) can be modulated by delayed glucocorticoid feedback as well as factors controlling glucocorticoid metabolism. The timing of both ACTH and corticosterone responses are dependent on stressor modality and intensity. Modified from (68).
Figure 3
Figure 3
Neural mechanisms of acute stress excitation. Data suggest corticotropin releasing hormone neurons in the medial dorsal paraventricular nucleus (mpPVN) can be driven by neurons communicating homeostatic challenge, including the nucleus of the solitary tract (NTS), among others. The PVN also has numerous connections with hypothalamic nuclei and subcortical telencephalic structures, including excitatory (posterior hypothalamus (PH), ventrolateral region of the bed nucleus of the stria terminalis (BST)) and inhibitory (medial preoptic nucleus (mPOA), dorsomedial nucleus (DMH), periPVN, and posterior BST) inputs. Inhibitory input to the PVN provides a substantial inhibitory tone, which can be disrupted by inhibition from upstream sites such as the medial and central amygdaloid nuclei (MeA, CeA), providing a mechanism for transsynaptic disinhibition from the limbic forebrain. There is also some evidence suggesting that some cortical regions, such as the infralimbic region (il) of the medial prefrontal cortex, may also provide transsynaptic excitation, perhaps via relays in the brainstem. There is less evidence for excitatory input from other forebrain stress circuits, such as the ventral subiculum (vSUB), prelimbic division of the mPFC or paraventricular thalamus. Input from limbic regions may also access the PVN by interaction with local interneurons in the PVN surround (periPVN). Open circles: inhibitory (e.g., GABAergic) neurons; closed circles: excitatory (e.g., glutamatergic) neurons; squares: inhibitory input; arrowheads: excitatory inputs. Adapted from (79), with permission.
Figure 4
Figure 4
Neural mechanisms of acute stress inhibition. As noted, the PVN receives substantial inhibitory input from hypothalamic (mPOA, DMH, periPVN) and medial forebrain (BST) structures. The regions receive excitatory inputs from forebrain structures such as the IL, PL and vSUB, which are thought to mediate trans-synaptic inhibition of HPA axis stress responses. Upstream limbic pathways may also limit drive of the mpPVN by way of local inhibition of HPA axis excitatory circuits, e.g., the NTS and/or PH. See Figure 3 legend for abbreviations. Adapted from (79), with permission.
Figure 5
Figure 5
Habituation of glucocorticoid stress responses following chronic stress, often observed after repeated or predictable stressor exposure. Modified from (68)
Figure 6
Figure 6
Potential glucocorticoid profiles seen following non-habituating chronic stressors (e.g., seen after chronic unpredictable stress, chronic social stress or severe stress regimens). Depending on both the regimen and the individual, chronic stress profiles may be manifest as increased basal glucocorticoid secretion (usually at the time of the circadian nadir); delayed shut-off of the stress response (due to reduced feedback efficacy); facilitated or sensitized responses to novel stressors; or in extreme cases, hyporesponsiveness driven by adrenal exhaustion. Modified from (68).
Figure 7
Figure 7
Neural mechanisms controlling chronic stress regulation of the HPA axis. Pathways responsible for drive of the HPA axis under chronic stress are not as well understood as those mediating acute response. There is strong evidence that the PVT, which is not involved in acute stress excitation or inhibition, is required for both stress habituation and stress facilitation, suggesting a role in communicating stress chronicity. Importantly, the PVT has extensive reciprocal projections to the IL, PL and vSUB, as well as projections to the area of the BST. Neuronal activation studies indicate the existence of a small network of structures that are differentially activated by chronic unpredictable stress (relative to restraint), including the IL, PL, PH and NTS. Importantly, the PH and NTS are both connected with the IL, and both mediate acute stress excitation, suggesting a possible integrated circuit mediating chronic stress drive. Finally, chronic stress increases tone of CRH-expressing stress circuitry, suggesting that CRH systems may be recruited by chronic stress and participate in HPA axis hyperdrive. See Figure 3 legend for abbreviations. Adapted from (79), with permission.
Figure 8
Figure 8
Inverted U-shaped relationship between increasing levels of glucocorticoids (arrow) and ‘systems performance’ (e.g., spatial memory). Optimal systems performance is generally observed at intermediate levels of glucocorticoid availability, consistent with the need for glucocorticoids to supply an appropriate context for adaptation. Performance is generally degraded if glucocorticoid secretion is insufficient or hyperresponsive. See deKloet (1998) (32) for discussion. Modified from (68).
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Accorsi-Mendonca D, Machado BH. Synaptic transmission of baro- and chemoreceptors afferents in the NTS second order neurons. Auton Neurosci. 2013;175:3–8. - PubMed
    1. Aguilera G. Regulation of pituitary ACTH secretion during chronic stress. Front Neuroendocrinol. 1994;15:321–350. - PubMed
    1. Aguilera G, Rabadan-Diehl C. Vasopressinergic regulation of the hypothalamic-pituitary-adrenal axis: implications for stress adaptation. Regul Pept. 2000;96:23–29. - PubMed
    1. Akana SF, Dallman MF, Bradbury MJ, Scribner KA, Strack AM, Walker CD. Feedback and facilitation in the adrenocortical system: unmasking facilitation by partial inhibition of the glucocorticoid response to prior stress. Endocrinology. 1992;131:57–68. - PubMed
    1. Albeck DS, McKittrick CR, Blanchard DC, Blanchard RJ, Nikulina J, McEwen BS, Sakai RR. Chronic social stress alters levels of corticotropin-releasing factor and arginine vasopressin mRNA in rat brain. J Neurosci. 1997;17:4895–4903. - PMC - PubMed

MeSH terms

Substances