Comparison Between Tadalafil Plus Paroxetine and Paroxetine Alone in the Treatment of Premature Ejaculation
- PMID: 26981497
- PMCID: PMC4780280
- DOI: 10.5812/numonthly.32286
Comparison Between Tadalafil Plus Paroxetine and Paroxetine Alone in the Treatment of Premature Ejaculation
Abstract
Background: Several recent studies have investigated the therapeutic role of phosphodiesterase type 5 (PDE5) inhibitors in premature ejaculation (PE) used in the treatment of erectile dysfunction.
Objectives: In the present research, the efficacy of paroxetine alone and paroxetine plus tadalafil was compared in patients referred because of premature ejaculation.
Patients and methods: This quasi-experimental study was performed on 100 consecutive 17 to 49-year-old potent men with premature ejaculation and without any clear organic disease. All patients had lifelong PE with an intravaginal ejaculation latency time (IELT) shorter than 1.5 minutes. Informed consent was obtained from all patients who were randomly divided into two groups using a computer-generated random tabulation list. In group A, patients received 10 mg paroxetine daily, in addition to four hours before planned sexual activity. In group B, 10 mg paroxetine was taken daily, plus 10 mg tadalafil one hour before planned sexual activity. The duration of the intervention was six months and patients were evaluated for IELT three and six months after the beginning of therapy.
Results: The mean age of patients in groups A and B were 33 ± 9.6 and 31.2 ± 9.3 years, respectively (P = 0.368). The mean number of intercourses were 1.08 ± 0.6 and 1.12 ± 0.6 per week in groups A and B, respectively (P = 0.791). Mean IELT at the 3-month follow up in groups A and B was 4.5 ± 1.5 and 5 ± 2.4 minutes, respectively (P = 0.285) and at the 6-month follow up was 4.8 ± 1 and 5.3 ± 2 minutes, respectively (P = 0.278).
Conclusions: The results of the study show that tadalafil can increase the mean IELT and can be used for treatment of premature ejaculation in combination with paroxetine.
Keywords: Paroxetine Tadalafil Plus Paroxetine and Paroxetine; Premature Ejaculation; Serotonin Uptake Inhibitors.
Figures
Similar articles
-
Retrospective evaluation of the efficacy of daily paroxetine/tadalafil combination in patients with premature ejaculation and erectile dysfunction.Eur Rev Med Pharmacol Sci. 2023 May;27(9):4248-4253. doi: 10.26355/eurrev_202305_32335. Eur Rev Med Pharmacol Sci. 2023. PMID: 37203851
-
Effect of a tadalafil 5-mg single daily dose on lifelong premature ejaculation: A single-blinded placebo-controlled study.Arab J Urol. 2022 Feb 26;20(2):100-104. doi: 10.1080/2090598X.2021.2007464. eCollection 2022. Arab J Urol. 2022. PMID: 35530567 Free PMC article.
-
Tadalafil and fluoxetine in premature ejaculation: prospective, randomized, double-blind, placebo-controlled study.Urol Int. 2008;80(2):162-5. doi: 10.1159/000112607. Epub 2008 Mar 19. Urol Int. 2008. PMID: 18362486 Clinical Trial.
-
The role of phosphodiesterase type 5 inhibitors in the management of premature ejaculation: a critical analysis of basic science and clinical data.Eur Urol. 2007 Nov;52(5):1331-9. doi: 10.1016/j.eururo.2007.08.005. Epub 2007 Aug 17. Eur Urol. 2007. PMID: 17728050 Review.
-
An evidence-based unified definition of lifelong and acquired premature ejaculation: report of the second International Society for Sexual Medicine Ad Hoc Committee for the Definition of Premature Ejaculation.J Sex Med. 2014 Jun;11(6):1423-41. doi: 10.1111/jsm.12524. Epub 2014 May 22. J Sex Med. 2014. PMID: 24848805 Review.
Cited by
-
Prospective comparison of tadalafil 5 mg, dapoxetine 30 mg, and the combination of both in the treatment of premature ejaculation.Arab J Urol. 2023 Nov 6;22(2):81-88. doi: 10.1080/20905998.2023.2277081. eCollection 2024. Arab J Urol. 2023. PMID: 38481411 Free PMC article.
-
Current and emerging treatment options for premature ejaculation.Nat Rev Urol. 2022 Nov;19(11):659-680. doi: 10.1038/s41585-022-00639-5. Epub 2022 Aug 25. Nat Rev Urol. 2022. PMID: 36008555 Review.
-
Redefining a sexual medicine paradigm: subclinical premature ejaculation as a new taxonomic entity.Nat Rev Urol. 2021 Feb;18(2):115-127. doi: 10.1038/s41585-020-00417-1. Epub 2021 Jan 13. Nat Rev Urol. 2021. PMID: 33442049 Review.
-
Progresses in pharmaceutical and surgical management of premature ejaculation.Chin Med J (Engl). 2019 Oct 5;132(19):2362-2372. doi: 10.1097/CM9.0000000000000433. Chin Med J (Engl). 2019. PMID: 31567373 Free PMC article. Review.
-
Paroxetine in the treatment of premature ejaculation: a systematic review and meta-analysis.BMC Urol. 2019 Jan 3;19(1):2. doi: 10.1186/s12894-018-0431-7. BMC Urol. 2019. PMID: 30606186 Free PMC article.
References
LinkOut - more resources
Full Text Sources
Other Literature Sources