Review
doi: 10.1016/j.carres.2016.01.009.
Epub 2016 Jan 27.
Marine cytotoxic jaspine B and its stereoisomers: biological activity and syntheses
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- PMID: 26878486
- DOI: 10.1016/j.carres.2016.01.009
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Review
Marine cytotoxic jaspine B and its stereoisomers: biological activity and syntheses
Carbohydr Res.
.
Abstract
Conformationally constrained sphingolipids such as anhydrophytosphingosines represented by jaspine B (also known as pachastrissamine) and its stereoisomers have become an attractive and timely target for total synthesis due to their significant biological activity as well as the unique structures. This review article describes the biological activity and chemistry of the natural jaspine B and its seven stereoisomers.
Keywords: Anhydrophytosphingosines; Asymmetric synthesis; Cytotoxic activity; Jaspine B; Sphingolipids; Stereoselective synthesis.
Copyright © 2016 Elsevier Ltd. All rights reserved.
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