The Cellular and Molecular Landscapes of the Developing Human Central Nervous System
- PMID: 26796689
- PMCID: PMC4959909
- DOI: 10.1016/j.neuron.2015.12.008
The Cellular and Molecular Landscapes of the Developing Human Central Nervous System
Abstract
The human CNS follows a pattern of development typical of all mammals, but certain neurodevelopmental features are highly derived. Building the human CNS requires the precise orchestration and coordination of myriad molecular and cellular processes across a staggering array of cell types and over a long period of time. Dysregulation of these processes affects the structure and function of the CNS and can lead to neurological or psychiatric disorders. Recent technological advances and increased focus on human neurodevelopment have enabled a more comprehensive characterization of the human CNS and its development in both health and disease. The aim of this review is to highlight recent advancements in our understanding of the molecular and cellular landscapes of the developing human CNS, with focus on the cerebral neocortex, and the insights these findings provide into human neural evolution, function, and dysfunction.
Keywords: brain development; developmental milestones; evolution; genomics; lateralization; neurodevelopmental disorders; regulatory elements; species differences; transcription factor.
Copyright © 2016 Elsevier Inc. All rights reserved.
Conflict of interest statement
The authors declare no conflicts of interest.
Figures
![Figure 1](https://cdn.statically.io/img/www.ncbi.nlm.nih.gov/pmc/articles/instance/4959909/bin/nihms746640f1.gif)
![Figure 2](https://cdn.statically.io/img/www.ncbi.nlm.nih.gov/pmc/articles/instance/4959909/bin/nihms746640f2.gif)
![Figure 3](https://cdn.statically.io/img/www.ncbi.nlm.nih.gov/pmc/articles/instance/4959909/bin/nihms746640f3.gif)
![Figure 4](https://cdn.statically.io/img/www.ncbi.nlm.nih.gov/pmc/articles/instance/4959909/bin/nihms746640f4.gif)
![Figure 5](https://cdn.statically.io/img/www.ncbi.nlm.nih.gov/pmc/articles/instance/4959909/bin/nihms746640f5.gif)
![Figure 6](https://cdn.statically.io/img/www.ncbi.nlm.nih.gov/pmc/articles/instance/4959909/bin/nihms746640f6.gif)
![Figure 7](https://cdn.statically.io/img/www.ncbi.nlm.nih.gov/pmc/articles/instance/4959909/bin/nihms746640f7.gif)
Similar articles
-
Cell fate control in the developing central nervous system.Exp Cell Res. 2014 Feb 1;321(1):77-83. doi: 10.1016/j.yexcr.2013.10.003. Epub 2013 Oct 16. Exp Cell Res. 2014. PMID: 24140262 Review.
-
Autophagy in mammalian neurodevelopment and implications for childhood neurological disorders.Neurosci Lett. 2019 Apr 1;697:29-33. doi: 10.1016/j.neulet.2018.04.017. Epub 2018 Apr 14. Neurosci Lett. 2019. PMID: 29665429 Review.
-
Long noncoding RNAs in development and disease of the central nervous system.Trends Genet. 2013 Aug;29(8):461-8. doi: 10.1016/j.tig.2013.03.002. Epub 2013 Apr 4. Trends Genet. 2013. PMID: 23562612 Review.
-
Development of the serotoninergic system in the central nervous system of a shark, the lesser spotted dogfish Scyliorhinus canicula.J Comp Neurol. 2008 Dec 20;511(6):804-31. doi: 10.1002/cne.21857. J Comp Neurol. 2008. PMID: 18925650
-
Human brain organogenesis: Toward a cellular understanding of development and disease.Cell. 2022 Jan 6;185(1):42-61. doi: 10.1016/j.cell.2021.10.003. Epub 2021 Nov 12. Cell. 2022. PMID: 34774127 Review.
Cited by
-
Analysis of human neuronal cells carrying ASTN2 deletion associated with psychiatric disorders.Transl Psychiatry. 2024 Jun 3;14(1):236. doi: 10.1038/s41398-024-02962-4. Transl Psychiatry. 2024. PMID: 38830862 Free PMC article.
-
Neurobiology of cognitive abilities in early childhood autism.JCPP Adv. 2024 Jan 20;4(2):e12214. doi: 10.1002/jcv2.12214. eCollection 2024 Jun. JCPP Adv. 2024. PMID: 38827984 Free PMC article.
-
Air and Noise Pollution Exposure in Early Life and Mental Health From Adolescence to Young Adulthood.JAMA Netw Open. 2024 May 1;7(5):e2412169. doi: 10.1001/jamanetworkopen.2024.12169. JAMA Netw Open. 2024. PMID: 38805229 Free PMC article.
-
Alterations in spatiotemporal characteristics of dynamic networks in juvenile myoclonic epilepsy.Neurol Sci. 2024 May 4. doi: 10.1007/s10072-024-07506-8. Online ahead of print. Neurol Sci. 2024. PMID: 38704479
-
Unveiling Promising Neuroimaging Biomarkers for Schizophrenia Through Clinical and Genetic Perspectives.Neurosci Bull. 2024 May 4. doi: 10.1007/s12264-024-01214-1. Online ahead of print. Neurosci Bull. 2024. PMID: 38703276 Review.
References
-
- Aldama J. Cytoarchitektonik der Großhirnrinde eines 5 jährigen und eines 1 jährigen Kindes. Z Ges Neurol Psychiat. 1930;130:532–626.
-
- Amsterdam B. Mirror self-image reactions before age two. Dev Psychobiol. 1972;5:297–305. - PubMed
-
- Amunts K, Schleicher A, Ditterich A, Zilles K. Broca’s region: cytoarchitectonic asymmetry and developmental changes. J Comp Neurol. 2003;465:72–89. - PubMed
-
- Azevedo FA, Carvalho LR, Grinberg LT, Farfel JM, Ferretti RE, Leite RE, Jacob Filho W, Lent R, Herculano-Houzel S. Equal numbers of neuronal and nonneuronal cells make the human brain an isometrically scaled-up primate brain. J Comp Neurol. 2009;513:532–541. - PubMed
Publication types
MeSH terms
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources