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. 2016 Mar;46(4):841-54.
doi: 10.1017/S0033291715002342. Epub 2015 Nov 27.

Effect of high-potency cannabis on corpus callosum microstructure

S Rigucci  1 , T R Marques  2 , M Di Forti  2 , H Taylor  2 , F Dell'Acqua  3 , V Mondelli  4 , S Bonaccorso  2 , A Simmons  3 , A S David  2 , P Girardi  1 , C M Pariante  4 , R M Murray  2 , P Dazzan  2
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Effect of high-potency cannabis on corpus callosum microstructure

S Rigucci et al. Psychol Med. 2016 Mar.

Abstract

Background: The use of cannabis with higher Δ9-tetrahydrocannabinol content has been associated with greater risk, and earlier onset, of psychosis. However, the effect of cannabis potency on brain morphology has never been explored. Here, we investigated whether cannabis potency and pattern of use are associated with changes in corpus callosum (CC) microstructural organization, in patients with first-episode psychosis (FEP) and individuals without psychosis, cannabis users and non-users.

Method: The CC of 56 FEP (37 cannabis users) and 43 individuals without psychosis (22 cannabis users) was virtually dissected and segmented using diffusion tensor imaging tractography. The diffusion index of fractional anisotropy, mean diffusivity (MD), axial diffusivity (AD) and radial diffusivity was calculated for each segment.

Results: Across the whole sample, users of high-potency cannabis had higher total CC MD and higher total CC AD than both low-potency users and those who never used (p = 0.005 and p = 0.004, respectively). Daily users also had higher total CC MD and higher total CC AD than both occasional users and those who never used (p = 0.001 and p < 0.001, respectively). However, there was no effect of group (patient/individuals without psychosis) or group x potency interaction for either potency or frequency of use. The within-group analysis showed in fact that the effects of potency and frequency were similar in FEP users and in users without psychosis.

Conclusions: Frequent use of high-potency cannabis is associated with disturbed callosal microstructural organization in individuals with and without psychosis. Since high-potency preparations are now replacing traditional herbal drugs in many European countries, raising awareness about the risks of high-potency cannabis is crucial.

Keywords: Cannabis; corpus callosum; first-episode psychosis; tractography; white matter.

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Figures

Fig. 1.
Fig. 1.
Corpus callosum tract: whole (a) and segmented (b). Regions of interest as defined according to Witelson (1989) subdivisions. RB, Rostral body; AMB, anterior mid-body; PMB, posterior mid-body; Ism, isthmus. For a colour figure, see the online version.
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