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Review
. 2016 Jul;1857(7):863-71.
doi: 10.1016/j.bbabio.2015.11.004. Epub 2015 Nov 10.

Oxidation of NADH and ROS production by respiratory complex I

Andrei D Vinogradov  1 , Vera G Grivennikova  2
Affiliations
Free article
Review

Oxidation of NADH and ROS production by respiratory complex I

Andrei D Vinogradov et al. Biochim Biophys Acta. 2016 Jul.
Free article

Abstract

Kinetic characteristics of the proton-pumping NADH:quinone reductases (respiratory complexes I) are reviewed. Unsolved problems of the redox-linked proton translocation activities are outlined. The parameters of complex I-mediated superoxide/hydrogen peroxide generation are summarized, and the physiological significance of mitochondrial ROS production is discussed. This article is part of a Special Issue entitled Respiratory complex I, edited by Volker Zickermann and Ulrich Brandt.

Keywords: Bacterial plasma membranes; Hydrogen peroxide; Mitochondria; NADH:quinone oxidoreductase; Proton pumping; Superoxide.

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