Inflammation and preterm birth
- PMID: 26538528
- DOI: 10.1189/jlb.3MR0615-272RR
Inflammation and preterm birth
Abstract
Preterm birth is the leading cause of neonatal morbidity and mortality. Although the underlying causes of pregnancy-associated complication are numerous, it is well established that infection and inflammation represent a highly significant risk factor in preterm birth. However, despite the clinical and public health significance, infectious agents, molecular trigger(s), and immune pathways underlying the pathogenesis of preterm birth remain underdefined and represent a major gap in knowledge. Here, we provide an overview of recent clinical and animal model data focused on the interplay between infection-driven inflammation and induction of preterm birth. Furthermore, here, we highlight the critical gaps in knowledge that warrant future investigations into the interplay between immune responses and induction of preterm birth.
Keywords: Toll-like receptors; cytokines; infection; innate immune cells.
© Society for Leukocyte Biology.
Similar articles
-
Human innate immunosenescence: causes and consequences for immunity in old age.Trends Immunol. 2009 Jul;30(7):325-33. doi: 10.1016/j.it.2009.05.004. Epub 2009 Jun 21. Trends Immunol. 2009. PMID: 19541535 Free PMC article. Review.
-
Animal models of preterm birth.Trends Endocrinol Metab. 2004 Dec;15(10):479-87. doi: 10.1016/j.tem.2004.10.009. Trends Endocrinol Metab. 2004. PMID: 15541647 Review.
-
Intrauterine inflammation and preterm delivery.Ann N Y Acad Sci. 2010 Sep;1205:118-22. doi: 10.1111/j.1749-6632.2010.05684.x. Ann N Y Acad Sci. 2010. PMID: 20840262 Review.
-
Activation of decidual invariant natural killer T cells promotes lipopolysaccharide-induced preterm birth.Mol Hum Reprod. 2015 Apr;21(4):369-81. doi: 10.1093/molehr/gav001. Epub 2015 Jan 14. Mol Hum Reprod. 2015. PMID: 25589517
-
Maternal regulation of inflammatory cues is required for induction of preterm birth.JCI Insight. 2020 Nov 19;5(22):e138812. doi: 10.1172/jci.insight.138812. JCI Insight. 2020. PMID: 33208552 Free PMC article.
Cited by
-
Genetic polymorphisms associated with adverse pregnancy outcomes in nulliparas.Sci Rep. 2024 May 7;14(1):10514. doi: 10.1038/s41598-024-61218-9. Sci Rep. 2024. PMID: 38714721 Free PMC article.
-
Inflammatory Dietary Potential Is Associated with Vitamin Depletion and Gut Microbial Dysbiosis in Early Pregnancy.Nutrients. 2024 Mar 24;16(7):935. doi: 10.3390/nu16070935. Nutrients. 2024. PMID: 38612969 Free PMC article.
-
Decidual leukocytes respond to African lineage Zika virus infection with mild anti-inflammatory changes during acute infection in rhesus macaques.Front Immunol. 2024 Mar 7;15:1363169. doi: 10.3389/fimmu.2024.1363169. eCollection 2024. Front Immunol. 2024. PMID: 38515747 Free PMC article.
-
Mesenchymal Stem Cells Suppress Inflammatory Cytokines in Lipopolysaccharide Exposed Preterm and Term Human Pregnant Myometrial Cells.AJP Rep. 2024 Feb 18;14(1):e69-e73. doi: 10.1055/a-2216-9194. eCollection 2024 Jan. AJP Rep. 2024. PMID: 38370325 Free PMC article.
-
Melatonin: the placental antioxidant and anti-inflammatory.Front Immunol. 2024 Feb 1;15:1339304. doi: 10.3389/fimmu.2024.1339304. eCollection 2024. Front Immunol. 2024. PMID: 38361952 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Miscellaneous