The Link between Psychological Stress and Autoimmune Response in Children
- PMID: 26351146
- DOI: 10.1615/critrevimmunol.2015013255
The Link between Psychological Stress and Autoimmune Response in Children
Abstract
Stress is defined as a state of threatened homeostasis or disharmony that is counteracted by a complex repertoire of physiological and behavioral adaptive responses in order to establish homeostasis. Confronted with a stressful condition, the nervous and immune systems initiate a coping process to maintain homeostasis in the body. Psychological stress, recognized as a public health issue in children and young adults, may be one mechanism to induce and maintain autoimmunity in children. It is necessary to increase our understanding of how psychological stress can affect the immune system at a young age because autoimmune diseases, especially type 1 diabetes, are alarmingly common in children. Psychological stress may be involved in other autoimmune diseases, such as celiac disease, systemic lupus erythematosus, and juvenile idiopathic arthritis, that frequently occur in children as well. This review summarizes the studies attempting to evaluate the link between psychological stress and autoimmune response in children. A number of them have observed that the autoimmune disease itself causes psychological stress. We are far from fully understanding how long-term psychological stress is linked to autoimmune response in children with a high risk of, or already diagnosed, autoimmune disease.
Similar articles
-
Psychological Stress, Intestinal Barrier Dysfunctions, and Autoimmune Disorders: An Overview.Front Immunol. 2020 Aug 25;11:1823. doi: 10.3389/fimmu.2020.01823. eCollection 2020. Front Immunol. 2020. PMID: 32983091 Free PMC article. Review.
-
Psychological stress may induce diabetes-related autoimmunity in infancy.Diabetes Care. 2005 Feb;28(2):290-5. doi: 10.2337/diacare.28.2.290. Diabetes Care. 2005. PMID: 15677781
-
Associated autoimmune diseases in children and adolescents with type 1 diabetes mellitus (T1DM).Autoimmun Rev. 2015 Sep;14(9):781-97. doi: 10.1016/j.autrev.2015.05.002. Epub 2015 May 20. Autoimmun Rev. 2015. PMID: 26001590 Review.
-
The role of stress in the mosaic of autoimmunity: An overlooked association.Autoimmun Rev. 2018 Oct;17(10):967-983. doi: 10.1016/j.autrev.2018.04.005. Epub 2018 Aug 14. Autoimmun Rev. 2018. PMID: 30118900 Review.
-
Stress system--organization, physiology and immunoregulation.Neuroimmunomodulation. 2006;13(5-6):257-67. doi: 10.1159/000104853. Epub 2007 Aug 6. Neuroimmunomodulation. 2006. PMID: 17709947 Review.
Cited by
-
"Mens Sana in Cute Sana"-A State of the Art of Mutual Etiopathogenetic Influence and Relevant Pathophysiological Pathways between Skin and Mental Disorders: An Integrated Approach to Contemporary Psychopathological Scenarios.Cells. 2023 Jul 12;12(14):1828. doi: 10.3390/cells12141828. Cells. 2023. PMID: 37508493 Free PMC article. Review.
-
Connection between Celiac Disease and Systemic Lupus Erythematosus in Children-A Development Model of Autoimmune Diseases Starting from What We Inherit to What We Eat.Nutrients. 2023 May 29;15(11):2535. doi: 10.3390/nu15112535. Nutrients. 2023. PMID: 37299501 Free PMC article. Review.
-
Immune-Mediated Diseases from the Point of View of Psychoneuroimmunoendocrinology.Biology (Basel). 2022 Jun 28;11(7):973. doi: 10.3390/biology11070973. Biology (Basel). 2022. PMID: 36101354 Free PMC article. Review.
-
Cumulative exposure to maternal psychological distress in the prenatal and postnatal periods and atopic dermatitis in children: findings from the TMM BirThree Cohort Study.BMC Pregnancy Childbirth. 2022 Mar 24;22(1):242. doi: 10.1186/s12884-022-04556-8. BMC Pregnancy Childbirth. 2022. PMID: 35331140 Free PMC article.
-
Orofacial pain in juvenile idiopathic arthritis is associated with stress as well as psychosocial and functional limitations.Pediatr Rheumatol Online J. 2019 Dec 19;17(1):83. doi: 10.1186/s12969-019-0385-7. Pediatr Rheumatol Online J. 2019. PMID: 31856854 Free PMC article.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Medical