Dehydroepiandrosterone (DHEA) and dehydroepiandrosterone-sulfate (DHEAS) and emotional processing - A behavioral and electrophysiological approach
- PMID: 26122298
- DOI: 10.1016/j.yhbeh.2015.06.005
Dehydroepiandrosterone (DHEA) and dehydroepiandrosterone-sulfate (DHEAS) and emotional processing - A behavioral and electrophysiological approach
Abstract
Dehydroepiandrosterone (DHEA) and dehydroepiandrosterone-sulfate (DHEAS) may have mood enhancement effects: higher DHEAS concentrations and DHEA/cortisol ratio have been related to lower depression scores and controlled trials of DHEA administration have reported significant antidepressant effects. The balance between DHEAS and DHEA has been suggested to influence brain functioning. We explored DHEAS, DHEA, cortisol, DHEA/cortisol and DHEAS/DHEA ratios relations to the processing of negative emotional stimuli at behavioral and brain levels by recording the electroencephalogram of 21 young women while performing a visual task with implicit neutral or negative emotional content in an audio-visual oddball paradigm. For each condition, salivary DHEA, DHEAS and cortisol were measured before performing the task and at 30 and 60min intervals. DHEA increased after task performance, independent of the implicit emotional content. With implicit negative emotion, higher DHEAS/DHEA and DHEA/cortisol ratios before task performance were related to shorter visual P300 latencies suggesting faster brain processing under a negative emotional context. In addition, higher DHEAS/DHEA ratios were related to reduced visual P300 amplitudes, indicating less processing of the negative emotional stimuli. With this study, we could show that at the electrophysiological level, higher DHEAS/DHEA and DHEA/cortisol ratios were related to shorter stimulus evaluation times suggesting less interference of the implicit negative content of the stimuli with the task. Furthermore, higher DHEAS/DHEA ratios were related to reduced processing of negative emotional stimuli which may eventually constitute a protective mechanism against negative information overload.
Keywords: Auditory distraction; Cortisol; Dehydroepiandrosterone; Dehydroepiandrosterone reactivity; Dehydroepiandrosterone-sulfate; Emotion processing; Event-related-potentials; Performance.
Copyright © 2015. Published by Elsevier Inc.
Similar articles
-
Dehydroepiandrosterone and Dehydroepiandrosterone-Sulfate and Emotional Processing.Vitam Horm. 2018;108:413-441. doi: 10.1016/bs.vh.2018.01.022. Epub 2018 Mar 9. Vitam Horm. 2018. PMID: 30029737
-
Hormonal modulation of novelty processing in women: Enhanced under working memory load with high dehydroepiandrosterone-sulfate-to-dehydroepiandrosterone ratios.Neurosci Lett. 2016 Nov 10;634:98-103. doi: 10.1016/j.neulet.2016.10.002. Epub 2016 Oct 4. Neurosci Lett. 2016. PMID: 27717832
-
The relationship between dehydroepiandrosterone (DHEA), working memory and distraction--a behavioral and electrophysiological approach.PLoS One. 2014 Aug 8;9(8):e104869. doi: 10.1371/journal.pone.0104869. eCollection 2014. PLoS One. 2014. PMID: 25105970 Free PMC article.
-
Dehydroepiandrosterone, dehydroepiandrosterone sulphate and cardiovascular disease.J Endocrinol. 1996 Sep;150 Suppl:S149-53. J Endocrinol. 1996. PMID: 8943798 Review.
-
Do DHEA/DHEAS play a protective role in coronary heart disease?Physiol Res. 2000;49 Suppl 1:S43-56. Physiol Res. 2000. PMID: 10984071 Review.
Cited by
-
Neuroactive Steroids, Toll-like Receptors, and Neuroimmune Regulation: Insights into Their Impact on Neuropsychiatric Disorders.Life (Basel). 2024 Apr 30;14(5):582. doi: 10.3390/life14050582. Life (Basel). 2024. PMID: 38792602 Free PMC article. Review.
-
The Relationships Among Testosterone, Cortisol, and Cognitive Control of Emotion as Underlying Mechanisms of Emotional Intelligence of 10- to 11-Year-Old Children.Front Behav Neurosci. 2019 Dec 17;13:273. doi: 10.3389/fnbeh.2019.00273. eCollection 2019. Front Behav Neurosci. 2019. PMID: 31920581 Free PMC article.
-
Prechemotherapy Levels of Plasma Dehydroepiandrosterone and Its Sulfated Form as Predictors of Cancer-Related Cognitive Impairment in Patients with Breast Cancer Receiving Chemotherapy.Pharmacotherapy. 2019 May;39(5):553-563. doi: 10.1002/phar.2259. Epub 2019 Apr 4. Pharmacotherapy. 2019. PMID: 30892712 Free PMC article.
-
Cortisol/DHEA ratio and hippocampal volume: A pilot study in major depression and healthy controls.Psychoneuroendocrinology. 2016 Oct;72:139-46. doi: 10.1016/j.psyneuen.2016.06.017. Epub 2016 Jun 28. Psychoneuroendocrinology. 2016. PMID: 27428086 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Miscellaneous