The prevalence of clinically diagnosed ankylosing spondylitis and its clinical manifestations: a nationwide register study
- PMID: 25956915
- PMCID: PMC4424886
- DOI: 10.1186/s13075-015-0627-0
The prevalence of clinically diagnosed ankylosing spondylitis and its clinical manifestations: a nationwide register study
Abstract
Introduction: Prevalence estimates of ankylosing spondylitis vary considerably, and there are few nationwide estimates. The present study aimed to describe the national prevalence of clinically diagnosed ankylosing spondylitis in Sweden, stratified according to age, sex, geographical, and socio-economic factors, and according to subgroups with ankylosing spondylitis-related clinical manifestations and pharmacological treatment.
Methods: All individuals diagnosed with ankylosing spondylitis according to the World Health Organization International Classification of Disease codes, between 1967 and 2009, were identified from the National Patient Register. Data regarding disease manifestations, patient demographics, level of education, pharmacological treatment, and geographical region were retrieved from the National Patient Register and other national registers.
Results: A total of 11,030 cases with an ankylosing spondylitis diagnosis (alive, living in Sweden, and 16 to 64 years old in December 2009) were identified in the National Patient Register, giving a point prevalence of 0.18% in 2009. The prevalence was higher in northern Sweden, and lower in those with a higher level of education. Men had a higher prevalence of ankylosing spondylitis (0.23% versus 0.14%, P < 0.001), a higher frequency of anterior uveitis (25.5% versus 20.0%, P < 0.001) and were more likely to receive tumor necrosis factor inhibitors than women (15.6% versus 11.8% in 2009, P < 0.001). Women were more likely than men to have peripheral arthritis (21.7% versus 15.3%, P < 0.001), psoriasis (8.0% versus 6.9%, P = 0.03), and treatment with oral corticosteroids (14.0% versus 10.4% in 2009, P < 0.001).
Conclusion: This nationwide, register-based study demonstrated a prevalence of clinically diagnosed ankylosing spondylitis of 0.18%. It revealed phenotypical and treatment differences between the sexes, as well as geographical and socio-economic differences in disease prevalence.
Figures
Similar articles
-
Presence of peripheral arthritis and male sex predicting continuation of anti-tumor necrosis factor therapy in ankylosing spondylitis: an observational prospective cohort study from the South Swedish Arthritis Treatment Group Register.Arthritis Care Res (Hoboken). 2010 Oct;62(10):1362-9. doi: 10.1002/acr.20258. Arthritis Care Res (Hoboken). 2010. PMID: 20506310
-
Ankylosing spondylitis, psoriatic arthritis, and risk of malignant lymphoma: a cohort study based on nationwide prospectively recorded data from Sweden.Arthritis Rheumatol. 2014 May;66(5):1282-90. doi: 10.1002/art.38339. Arthritis Rheumatol. 2014. PMID: 24782185
-
Mortality in ankylosing spondylitis: results from a nationwide population-based study.Ann Rheum Dis. 2016 Aug;75(8):1466-72. doi: 10.1136/annrheumdis-2015-207688. Epub 2015 Sep 2. Ann Rheum Dis. 2016. PMID: 26338036
-
Infliximab-induced psoriasis in treatment of Crohn's disease-associated ankylosing spondylitis: case report and review of 142 cases.J Drugs Dermatol. 2013 Aug;12(8):939-43. J Drugs Dermatol. 2013. PMID: 23986169 Review.
-
[HLA B 27 uveitis in ankylosing spondylitis and reactive arthritis].Oftalmologia. 2010;54(1):29-35. Oftalmologia. 2010. PMID: 20540366 Review. Romanian.
Cited by
-
The prevalence of chronic obstructive pulmonary disease in patients with spondyloarthritis compared to the general population in the southernmost region of Sweden: a case-control study.Clin Exp Med. 2024 Apr 10;24(1):75. doi: 10.1007/s10238-024-01335-x. Clin Exp Med. 2024. PMID: 38598034 Free PMC article.
-
Exploring causal correlations between inflammatory cytokines and ankylosing spondylitis: a bidirectional mendelian-randomization study.Front Immunol. 2023 Nov 20;14:1285106. doi: 10.3389/fimmu.2023.1285106. eCollection 2023. Front Immunol. 2023. PMID: 38054001 Free PMC article.
-
Physical function and sex differences in radiographic axial spondyloarthritis: a cross-sectional analysis on Bath Ankylosing Spondylitis Functional Index.Arthritis Res Ther. 2023 Sep 26;25(1):182. doi: 10.1186/s13075-023-03173-w. Arthritis Res Ther. 2023. PMID: 37749599 Free PMC article.
-
Role of HLA class I and II alleles in susceptibility to ankylosing spondylitis in Chinese Han.J Clin Lab Anal. 2023 Sep;37(17-18):e24964. doi: 10.1002/jcla.24964. Epub 2023 Sep 25. J Clin Lab Anal. 2023. PMID: 37747092 Free PMC article.
-
Minimally Invasive Surgery for Thoracolumbar Spinal Fractures in Patients With Ankylosing Spondylitis.Int J Spine Surg. 2023 Aug;17(4):526-533. doi: 10.14444/8478. Epub 2023 Jun 2. Int J Spine Surg. 2023. PMID: 37268432 Free PMC article.
References
-
- Dagfinrud H, Kjeken I, Mowinckel P, Hagen KB, Kvien TK. Impact of functional impairment in ankylosing spondylitis: impairment, activity limitation, and participation restrictions. J Rheumatol. 2005;32:516–23. - PubMed
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Research Materials