. 2015 Jun;204(3):299-303.

doi: 10.1016/j.tvjl.2015.03.023. Epub 2015 Mar 25.

[(18)F]-fluorodeoxyglucose positron emission tomography of the cat brain: A feasibility study to investigate osteoarthritis-associated pain

Affiliations

¹ Groupe de Recherche en Pharmacologie Animale du Québec (GREPAQ), Faculty of Veterinary Medicine, Université de Montréal, Saint-Hyacinthe, QC, Canada; Osteoarthritis Research Unit, University of Montreal Hospital Research Centre (CRCHUM), Department of Medicine, Faculty of Medicine, Université de Montréal, Montreal, QC, Canada.
² Laboratoire de recherche en imagerie et orthopédie (LIO), University of Montreal Hospital Research Centre (CRCHUM), École de Technologie Supérieure, Université du Québec, Montreal, QC, Canada.
³ Centre d'imagerie moléculaire de Sherbrooke (CIMS), Étienne-Le Bel Clinical Research Center, Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, QC, Canada; Department of Nuclear Medicine and Radiobiology, Faculty of Medicine and Health Sciences, Université de Sherbrooke, Sherbrooke, QC, Canada.
⁴ Centre d'imagerie moléculaire de Sherbrooke (CIMS), Étienne-Le Bel Clinical Research Center, Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, QC, Canada.
⁵ Osteoarthritis Research Unit, University of Montreal Hospital Research Centre (CRCHUM), Department of Medicine, Faculty of Medicine, Université de Montréal, Montreal, QC, Canada.
⁶ Groupe de Recherche en Pharmacologie Animale du Québec (GREPAQ), Faculty of Veterinary Medicine, Université de Montréal, Saint-Hyacinthe, QC, Canada; Osteoarthritis Research Unit, University of Montreal Hospital Research Centre (CRCHUM), Department of Medicine, Faculty of Medicine, Université de Montréal, Montreal, QC, Canada. Electronic address: eric.troncy@umontreal.ca.

PMID: 25951988
DOI: 10.1016/j.tvjl.2015.03.023

[(18)F]-fluorodeoxyglucose positron emission tomography of the cat brain: A feasibility study to investigate osteoarthritis-associated pain

Martin Guillot et al. Vet J. 2015 Jun.

. 2015 Jun;204(3):299-303.

doi: 10.1016/j.tvjl.2015.03.023. Epub 2015 Mar 25.

Affiliations

¹ Groupe de Recherche en Pharmacologie Animale du Québec (GREPAQ), Faculty of Veterinary Medicine, Université de Montréal, Saint-Hyacinthe, QC, Canada; Osteoarthritis Research Unit, University of Montreal Hospital Research Centre (CRCHUM), Department of Medicine, Faculty of Medicine, Université de Montréal, Montreal, QC, Canada.
² Laboratoire de recherche en imagerie et orthopédie (LIO), University of Montreal Hospital Research Centre (CRCHUM), École de Technologie Supérieure, Université du Québec, Montreal, QC, Canada.
³ Centre d'imagerie moléculaire de Sherbrooke (CIMS), Étienne-Le Bel Clinical Research Center, Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, QC, Canada; Department of Nuclear Medicine and Radiobiology, Faculty of Medicine and Health Sciences, Université de Sherbrooke, Sherbrooke, QC, Canada.
⁴ Centre d'imagerie moléculaire de Sherbrooke (CIMS), Étienne-Le Bel Clinical Research Center, Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, QC, Canada.
⁵ Osteoarthritis Research Unit, University of Montreal Hospital Research Centre (CRCHUM), Department of Medicine, Faculty of Medicine, Université de Montréal, Montreal, QC, Canada.
⁶ Groupe de Recherche en Pharmacologie Animale du Québec (GREPAQ), Faculty of Veterinary Medicine, Université de Montréal, Saint-Hyacinthe, QC, Canada; Osteoarthritis Research Unit, University of Montreal Hospital Research Centre (CRCHUM), Department of Medicine, Faculty of Medicine, Université de Montréal, Montreal, QC, Canada. Electronic address: eric.troncy@umontreal.ca.

PMID: 25951988
DOI: 10.1016/j.tvjl.2015.03.023

Abstract

The objective of this pilot study was to investigate central nervous system (CNS) changes related to osteoarthritis (OA)-associated chronic pain in cats using [(18)F]-fluorodeoxyglucose ((18)FDG) positron emission tomography (PET) imaging. The brains of five normal, healthy (non-OA) cats and seven cats with pain associated with naturally occurring OA were imaged using (18)FDG-PET during a standardized mild anesthesia protocol. The PET images were co-registered over a magnetic resonance image of a cat brain segmented into several regions of interest. Brain metabolism was assessed in these regions using standardized uptake values. The brain metabolism in the secondary somatosensory cortex, thalamus and periaqueductal gray matter was increased significantly (P ≤ 0.005) in OA cats compared with non-OA cats. This study indicates that (18)FDG-PET brain imaging in cats is feasible to investigate CNS changes related to chronic pain. The results also suggest that OA is associated with sustained nociceptive inputs and increased activity of the descending modulatory pathways.

Keywords: Brain imaging; Cat; Central sensitization; Chronic pain; Osteoarthritis; Positron emission tomography.

PubMed Disclaimer

Cited by

Concurrent Validation of MI-CAT(V), a Clinical Metrology Instrument for Veterinarians Assessing Osteoarthritis Pain in Cats, through Testing for Firocoxib Analgesic Efficacy in a Prospective, Randomized, Controlled, and Blinded Study.
Delsart A, Otis C, Leung VSY, Labelle É, Moreau M, Frezier M, Drag M, Martel-Pelletier J, Pelletier JP, Troncy E. Delsart A, et al. Animals (Basel). 2024 Feb 24;14(5):711. doi: 10.3390/ani14050711. Animals (Basel). 2024. PMID: 38473097 Free PMC article.
A Pilot Study of Cancer-Induced Bone Pain Using Validated Owner Questionnaires, Serum N-Telopeptide Concentration, Kinetic Analysis, and PET/CT.
Flesner BK, Torres BT, Hutcheson KD, Rindt H, Zalcman AR, Maitz CA. Flesner BK, et al. Front Vet Sci. 2021 Dec 16;8:637195. doi: 10.3389/fvets.2021.637195. eCollection 2021. Front Vet Sci. 2021. PMID: 34977203 Free PMC article.
Analgesic efficacy of tramadol in cats with naturally occurring osteoarthritis.
Monteiro BP, Klinck MP, Moreau M, Guillot M, Steagall PV, Pelletier JP, Martel-Pelletier J, Gauvin D, Del Castillo JR, Troncy E. Monteiro BP, et al. PLoS One. 2017 Apr 12;12(4):e0175565. doi: 10.1371/journal.pone.0175565. eCollection 2017. PLoS One. 2017. PMID: 28403198 Free PMC article. Clinical Trial.
Preliminary Validation and Reliability Testing of the Montreal Instrument for Cat Arthritis Testing, for Use by Veterinarians, in a Colony of Laboratory Cats.
Klinck MP, Rialland P, Guillot M, Moreau M, Frank D, Troncy E. Klinck MP, et al. Animals (Basel). 2015 Dec 2;5(4):1252-67. doi: 10.3390/ani5040410. Animals (Basel). 2015. PMID: 26633524 Free PMC article.

Publication types

Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions

Substances

Actions

Grants and funding

Canadian Institutes of Health Research/Canada

LinkOut - more resources

Full Text Sources
- Elsevier Science
Medical
- MedlinePlus Health Information
Miscellaneous
- NCI CPTAC Assay Portal

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

[(18)F]-fluorodeoxyglucose positron emission tomography of the cat brain: A feasibility study to investigate osteoarthritis-associated pain

Affiliations

[(18)F]-fluorodeoxyglucose positron emission tomography of the cat brain: A feasibility study to investigate osteoarthritis-associated pain

Authors

Affiliations

Abstract

Similar articles

Cited by

Publication types

MeSH terms

Substances

Grants and funding

LinkOut - more resources

Full Text Sources

Medical

Miscellaneous

Abstract

Similar articles

Cited by

Publication types

MeSH terms

Substances

Related information

Grants and funding

LinkOut - more resources

Full Text Sources

Medical

Miscellaneous