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Review
. 2015 Jun;15(6):789-99.
doi: 10.1586/14737159.2015.1036745. Epub 2015 Apr 12.

Molecular allergy diagnosis for the clinical characterization of asthma

Marina Sastre-Ibañez  1 , Joaquín Sastre
Affiliations
Review

Molecular allergy diagnosis for the clinical characterization of asthma

Marina Sastre-Ibañez et al. Expert Rev Mol Diagn. 2015 Jun.

Abstract

Defining the allergen sensitization of a patient with asthma at the molecular level by measuring specific IgE to purified natural or recombinant allergens can improve diagnostic accuracy and improve asthma phenotyping. Molecular diagnosis is possible thanks to the specificity of some markers of species-specific sensitization and resolve cross-reactivity phenomena from a true co-sensitization. None of this precision is possible with conventional allergy tests, and such information will eventually give clinicians the possibility to individualize the actions taken, including indications on reducing targeted-allergen exposure or selection of suitable allergens for specific immunotherapy, thereby increasing the safety and efficacy of immunotherapy. Nevertheless, all in vitro tests should be assessed alongside clinical history, as allergen sensitization does not necessarily imply clinical responsiveness.

Keywords: allergens; allergy; asthma; molecular diagnosis.

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