Brief report: symmetricity of radiographic and MRI-detected structural joint damage in persons with knee pain--the Joints on Glucosamine (JOG) Study
- PMID: 25746322
- DOI: 10.1016/j.joca.2015.02.169
Brief report: symmetricity of radiographic and MRI-detected structural joint damage in persons with knee pain--the Joints on Glucosamine (JOG) Study
Abstract
Objective: Most MRI-based osteoarthritis (OA) studies have focused on a single knee per person and thus, data on bilaterality is sparse. Study aim was to describe symmetricity of MRI-detected OA features in a cohort of subjects with knee pain.
Design: Participants were 169 subjects with chronic knee pain who had 3 T MRI of both knees using the same protocol as in the Osteoarthritis Initiative. Knees were read for cartilage damage, bone marrow lesions (BMLs), and meniscal damage according to the Whole-Organ Magnetic Resonance Imaging Score (WORMS) system. Chi(2) tests were used to compare the proportion of knees with unilateral tissue pathology to the proportion what would be expected if both knees were independent. We further used percent agreement and linear weighted kappa statistics to describe agreement of cartilage damage and BMLs in the same articular plates.
Results: 51.2% of participants were men, mean age was 52.1 (±6.2), mean BMI was 29.0 kg/m(2) (±4.1). All plates showed a significant higher degree of symmetricity for cartilage damage as evidenced by weighted kappas ranging from 0.32 to 0.59. For BMLs the degree of symmetricity was higher for the patella, trochlea, medial tibia, lateral femur, and medial femur; for meniscal damage the degree of unilaterality was lower for all medial meniscal subregions but not all lateral. Kappas ranged between 0.52 and 0.68 for cartilage and 0.30 and 0.55 for BMLs for the four subregions with highest agreement.
Conclusion: A higher degree of symmetricity of tissue damage than expected by chance was observed in this cohort of subjects with knee pain.
Keywords: Bone marrow lesion; Cartilage; MRI; Osteoarthritis; Symmetricity.
Copyright © 2015. Published by Elsevier Ltd.
Similar articles
-
Severe radiographic knee osteoarthritis--does Kellgren and Lawrence grade 4 represent end stage disease?--the MOST study.Osteoarthritis Cartilage. 2015 Sep;23(9):1499-505. doi: 10.1016/j.joca.2015.04.018. Epub 2015 Apr 28. Osteoarthritis Cartilage. 2015. PMID: 25929973 Free PMC article.
-
Baseline radiographic osteoarthritis and semi-quantitatively assessed meniscal damage and extrusion and cartilage damage on MRI is related to quantitatively defined cartilage thickness loss in knee osteoarthritis: the Multicenter Osteoarthritis Study.Osteoarthritis Cartilage. 2015 Dec;23(12):2191-2198. doi: 10.1016/j.joca.2015.06.017. Epub 2015 Jul 8. Osteoarthritis Cartilage. 2015. PMID: 26162806 Free PMC article.
-
The relation of MRI-detected structural damage in the medial and lateral patellofemoral joint to knee pain: the Multicenter and Framingham Osteoarthritis Studies.Osteoarthritis Cartilage. 2015 Apr;23(4):565-70. doi: 10.1016/j.joca.2014.12.023. Epub 2015 Jan 7. Osteoarthritis Cartilage. 2015. PMID: 25575967 Free PMC article.
-
Quantitative MR imaging of cartilage and trabecular bone in osteoarthritis.Radiol Clin North Am. 2009 Jul;47(4):655-73. doi: 10.1016/j.rcl.2009.03.002. Radiol Clin North Am. 2009. PMID: 19631074 Review.
-
Are biomechanical factors, meniscal pathology, and physical activity risk factors for bone marrow lesions at the knee? A systematic review.Semin Arthritis Rheum. 2013 Oct;43(2):187-94. doi: 10.1016/j.semarthrit.2013.03.002. Semin Arthritis Rheum. 2013. PMID: 24157092 Review.
Cited by
-
Magnetic Resonance Imaging-Defined Osteoarthritis Features and Anterior Knee Pain in Individuals With, or at Risk for, Knee Osteoarthritis: A Multicenter Study on Osteoarthritis.Arthritis Care Res (Hoboken). 2022 Sep;74(9):1533-1540. doi: 10.1002/acr.24604. Epub 2022 Jun 8. Arthritis Care Res (Hoboken). 2022. PMID: 33768706 Free PMC article.
-
Comparison of 2 Radiographic Techniques for Measurement of Tibiofemoral Joint Space Width.Orthop J Sports Med. 2017 Sep 26;5(9):2325967117728675. doi: 10.1177/2325967117728675. eCollection 2017 Sep. Orthop J Sports Med. 2017. PMID: 28989937 Free PMC article.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources