Structure of HDL: particle subclasses and molecular components
- PMID: 25522985
- DOI: 10.1007/978-3-319-09665-0_1
Structure of HDL: particle subclasses and molecular components
Abstract
A molecular understanding of high-density lipoprotein (HDL) will allow a more complete grasp of its interactions with key plasma remodelling factors and with cell-surface proteins that mediate HDL assembly and clearance. However, these particles are notoriously heterogeneous in terms of almost every physical, chemical and biological property. Furthermore, HDL particles have not lent themselves to high-resolution structural study through mainstream techniques like nuclear magnetic resonance and X-ray crystallography; investigators have therefore had to use a series of lower resolution methods to derive a general structural understanding of these enigmatic particles. This chapter reviews current knowledge of the composition, structure and heterogeneity of human plasma HDL. The multifaceted composition of the HDL proteome, the multiple major protein isoforms involving translational and posttranslational modifications, the rapidly expanding knowledge of the HDL lipidome, the highly complex world of HDL subclasses and putative models of HDL particle structure are extensively discussed. A brief history of structural studies of both plasma-derived and recombinant forms of HDL is presented with a focus on detailed structural models that have been derived from a range of techniques spanning mass spectrometry to molecular dynamics.
Similar articles
-
HDL subclass proteomic analysis and functional implication of protein dynamic change during HDL maturation.Redox Biol. 2019 Jun;24:101222. doi: 10.1016/j.redox.2019.101222. Epub 2019 May 17. Redox Biol. 2019. PMID: 31153037 Free PMC article.
-
Weight Loss and Exercise Alter the High-Density Lipoprotein Lipidome and Improve High-Density Lipoprotein Functionality in Metabolic Syndrome.Arterioscler Thromb Vasc Biol. 2018 Feb;38(2):438-447. doi: 10.1161/ATVBAHA.117.310212. Epub 2017 Dec 28. Arterioscler Thromb Vasc Biol. 2018. PMID: 29284607
-
Unraveling the complexities of the HDL lipidome.J Lipid Res. 2013 Nov;54(11):2950-63. doi: 10.1194/jlr.R036095. Epub 2013 Mar 30. J Lipid Res. 2013. PMID: 23543772 Free PMC article. Review.
-
Structural basis of human high-density lipoprotein formation and assembly at sub nanometer resolution.Methods Cell Biol. 2008;90:327-64. doi: 10.1016/S0091-679X(08)00815-7. Methods Cell Biol. 2008. PMID: 19195557
-
High density lipoprotein structure.Front Biosci. 2003 May 1;8:d1044-54. doi: 10.2741/1077. Front Biosci. 2003. PMID: 12700101 Review.
Cited by
-
Effects of phytosterol supplementation on lipoprotein subfractions and LDL particle quality.Sci Rep. 2024 May 15;14(1):11108. doi: 10.1038/s41598-024-61897-4. Sci Rep. 2024. PMID: 38750162 Free PMC article. Clinical Trial.
-
Interactions Between HDL and CD4+ T Cells: A Novel Understanding of HDL Anti-Inflammatory Properties.Arterioscler Thromb Vasc Biol. 2024 Jun;44(6):1191-1201. doi: 10.1161/ATVBAHA.124.320851. Epub 2024 Apr 25. Arterioscler Thromb Vasc Biol. 2024. PMID: 38660807 Review.
-
An atomistic characterization of high-density lipoproteins and the conserved "LN" region of apoA-I.Biophys J. 2024 May 7;123(9):1116-1128. doi: 10.1016/j.bpj.2024.03.039. Epub 2024 Mar 29. Biophys J. 2024. PMID: 38555508
-
APOB100 transgenic mice exemplify how the systemic circulation content may affect the retina without altering retinal cholesterol input.Cell Mol Life Sci. 2024 Jan 22;81(1):52. doi: 10.1007/s00018-023-05056-4. Cell Mol Life Sci. 2024. PMID: 38253888 Free PMC article.
-
Effect of adjuvant probiotic therapy (Lactobacillus reuteri) in the treatment of periodontitis associated with diabetes mellitus: clinical, controlled, and randomized study.Clin Oral Investig. 2024 Jan 6;28(1):80. doi: 10.1007/s00784-023-05441-0. Clin Oral Investig. 2024. PMID: 38183505 Clinical Trial.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources