Executive-affective connectivity in smokers viewing anti-smoking images: an fMRI study
- PMID: 25453167
- DOI: 10.1016/j.pscychresns.2014.10.018
Executive-affective connectivity in smokers viewing anti-smoking images: an fMRI study
Abstract
Despite knowledge of the harmful consequences of smoking on health, tobacco users continue to smoke. Neuroimaging studies have begun to provide insight into the mechanisms underlying this response. Regions involved in executive control and affective processing/persuasion are activated when viewing the negative value of smoking, but these systems can interact in ways that promote or hinder its impact on behavior. The goal of this functional magnetic resonance imaging (fMRI) study was to examine the dynamics between these systems during the processing of images designed to elicit a negative emotional response regarding tobacco smoking in a group of current smokers. Thirty chronic smokers passively viewed aversive smoking-related, aversive nonsmoking-related and neutral images presented in a block design while being scanned. Functional connectivity analyses showed that the left inferior frontal gyrus (IFG) is negatively associated to activity in medial frontal, cingulate, limbic, subcortical and parietal regions in chronic smokers during the processing of aversive smoking-related material, a pattern that was significantly greater when stimuli were drug-related compared with when they were nondrug-related. Our results suggest that individuals with tobacco dependence present different patterns of functional connectivity depending on whether the aversive stimuli are smoking- or nonsmoking-related. Activity in the left inferior frontal gyrus may act to down-regulate corresponding activity in regions key to an affective and persuasive response during the processing of anti-smoking material. This mechanism may reduce the extent to which "feeling bad" brings about a change in behavior.
Keywords: Addiction; Anti-smoking; Emotion; Inferior frontal gyrus; Tobacco; fMRI.
Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.
Similar articles
-
Where there's smoke, there's fire: the brain reactivity of chronic smokers when exposed to the negative value of smoking.Prog Neuropsychopharmacol Biol Psychiatry. 2014 Apr 3;50:66-73. doi: 10.1016/j.pnpbp.2013.12.009. Epub 2013 Dec 18. Prog Neuropsychopharmacol Biol Psychiatry. 2014. PMID: 24361634
-
Neural Basis of Smoking-Related Difficulties in Emotion Regulation.Int J Neuropsychopharmacol. 2020 Jul 29;23(7):409-416. doi: 10.1093/ijnp/pyaa015. Int J Neuropsychopharmacol. 2020. PMID: 32221527 Free PMC article.
-
Affective and executive network processing associated with persuasive antidrug messages.J Cogn Neurosci. 2013 Jul;25(7):1136-47. doi: 10.1162/jocn_a_00391. Epub 2013 Mar 26. J Cogn Neurosci. 2013. PMID: 23530896
-
Adolescent brain maturation and smoking: what we know and where we're headed.Neurosci Biobehav Rev. 2014 Sep;45:323-42. doi: 10.1016/j.neubiorev.2014.07.003. Epub 2014 Jul 12. Neurosci Biobehav Rev. 2014. PMID: 25025658 Free PMC article. Review.
-
Affect and cognitive control: Insights from research on effort mobilization.Int J Psychophysiol. 2019 Sep;143:116-125. doi: 10.1016/j.ijpsycho.2019.07.003. Epub 2019 Jul 11. Int J Psychophysiol. 2019. PMID: 31302145 Review.
Cited by
-
Time-evolving dynamics in brain networks forecast responses to health messaging.Netw Neurosci. 2018 Nov 1;3(1):138-156. doi: 10.1162/netn_a_00058. eCollection 2019. Netw Neurosci. 2018. PMID: 30793078 Free PMC article.
-
The persuasion network is modulated by drug-use risk and predicts anti-drug message effectiveness.Soc Cogn Affect Neurosci. 2017 Dec 1;12(12):1902-1915. doi: 10.1093/scan/nsx126. Soc Cogn Affect Neurosci. 2017. PMID: 29140500 Free PMC article.
-
Impaired Coupling between the Dorsomedial Prefrontal Cortex and the Amygdala in Schizophrenia Smokers Viewing Anti-smoking Images.Front Psychiatry. 2017 Jun 19;8:109. doi: 10.3389/fpsyt.2017.00109. eCollection 2017. Front Psychiatry. 2017. PMID: 28674507 Free PMC article.
-
Neural correlates of cigarette health warning avoidance among smokers.Drug Alcohol Depend. 2016 Apr 1;161:155-62. doi: 10.1016/j.drugalcdep.2016.01.025. Epub 2016 Feb 4. Drug Alcohol Depend. 2016. PMID: 26874916 Free PMC article.
Publication types
MeSH terms
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Research Materials